Control of massive bleeding of a pancreatic pseudoaneurysm penetrating into the colon by transcatheter arterial embolization.
Explore the source record for details and available documents.
Aneurysm↗
Biomedical subjects
O Matsui
Publications and source records attributed to O Matsui.
Magnetic resonance imaging of bladder hemangioma.
An 18-year-old woman with a bladder hemangioma is described. The tumor had a low signal intensity with multilocular pattern on T1-weighted magnetic resonance (MR) images and high signal intensity on T2-weighted MR images. MR images were useful in evaluating tumor character and its extent.
Adolescent↗
Visualization of the thymus with therapeutic doses of radioiodine in patients with thyroid cancer.
Two cases of papillary carcinoma of the thyroid are presented in which whole-body scans following therapeutic doses of iodine-131 revealed intense anterior mediastinal uptake. In both cases, the mediastinal uptake was absent from scans obtained after removal of the entire thymus. Histologically, the resected thymus glands showed hyperplasia and contained neither thyroid tissue nor metastatic foci of thyroid carcinoma. We therefore concluded that anterior mediastinal uptake of radioiodine may be caused by hyperplasia of the thymus.
Adult↗
Adenomatous hyperplasia of the liver as a precancerous lesion.
Adenomatous hyperplasia (AH), a hyperplastic parenchymal nodule, is detected most often through radiological and pathological observations in chronic advanced liver disease. AH can be classified into two categories: ordinary type or macroregenerative nodule (MRN) type I, and atypical type or MRN type II. Characteristically, both types contain portal tracts with portal veins and biliary elements. Ordinary AH may represent a large regenerative nodule with limited growth potential. Atypical AH shows slightly cellular and structural atypia, altered phenotypic expression, and increased proliferative activity compared to the surrounding liver. Histologic differentiation of atypical AH from well-differentiated hepatocellular carcinoma (HCC) is controversial, and generally accepted diagnostic criteria are still lacking. Atypical AH occasionally contains overt malignant foci. Histological observations and portography show that nodules of AH are supplied by portal venous blood. While AH nodules appear to be hypoperfused according to arteriographic studies, atypical AH contains small arterial branches which are abundant in contrast to the surrounding liver. The data obtained so far indicate that atypical AH may be a hepatocellular neoplasm which belongs nosologically to a gray area of neoplasm, in which overt HCC is likely to develop. It is clinically recommended that atypical AH is treated as "malignant" because of the occasional inclusion of HCC foci. For its treatment, percutaneous ethanol injection is becoming popular.
Carcinoma, Hepatocellular↗
Small hepatocellular carcinoma: treatment with subsegmental transcatheter arterial embolization.
The effectiveness of subsegmental transcatheter arterial embolization (TAE) therapy for small hepatocellular carcinomas (HCCs) was retrospectively analyzed. TAE was performed in 100 patients with liver cirrhosis. There was a total of 124 nodular-type HCCs less than 4 cm in diameter. TAE was performed by injecting a mixture of iodized oil and anticancer drugs followed by gelatin sponge particles or a mixture of iodized oil and absolute ethanol into the more distal branches of the subsegmental artery. Complete necrosis was seen at histologic examination in seven of 11 resected lesions. Among the remaining 113 lesions in 90 patients followed up without surgery, the 1-and 4-year local recurrence rates after TAE were 18% and 33%, respectively. The 1- and 4-year survival rates for 82 patients with Child class A or B disease were 100% and 67%, respectively. No substantial deterioration of liver function was observed. Subsegmental TAE improved the prognosis of the patients with liver cirrhosis associated with small HCCs.
Carcinoma, Hepatocellular↗
The characteristics of another small DNA virus isolated from a pig with diarrhea.
A small DNA virus was newly isolated from the small intestines of a pig with diarrhea in 1987, in Japan. Concerning the physicochemical properties, hemagglutination and susceptibility of cell culture to the virus, the virus was identical to a formerly isolated small DNA virus, the H-45 strain and also physicochemically similar to the parvovirus group. In a serological test however, the virus was distinctly, antigenically different from the H-45 strain as well as each of porcine, bovine and canine parvoviruses.
Animals↗
Rapidly growing mucinous cholangiocarcinoma.
A 65-year-old man was hospitalized due to an abdominal tumor. Several imaging studies showed multilocular tumors in the right hepatic lobe and in the pancreatic head, 4 and 7 cm in size, respectively. The hepatic tumor rapidly grew to 9 cm in 4 weeks, associated with a rapid increase in the serum carcinoembryonic antigen level from 125 ng/ml to 1,000 ng/ml. The pathologic diagnosis of the resected liver tumor was mucinous cholangiocarcinoma. This hepatic tumor produced a large amount of mucin, but did not secrete mucin into the bile ducts. Therefore, there was no obstructive jaundice. The incidentally accompanied pancreatic tumor was a typical serous cystadenoma. The present case suggested that mucinous cholangiocarcinoma could present rapid growth of the tumor. The clinicopathological features of mucinous cholangiocarcinoma are demonstrated for the first time, and the differences between mucinous cholangiocarcinoma and mucin-producing papillary adenocarcinoma of duct-spreading type are discussed.
Adenoma, Bile Duct↗
Postmortem survey of bile duct necrosis and biloma in hepatocellular carcinoma after transcatheter arterial chemoembolization therapy: relevance to microvascular damages of peribiliary capillary plexus.
The present study was aimed at determining the incidence of bile duct necrosis and biloma in hepatocellular carcinoma (HCC) after transcatheter arterial embolization therapy (TAE) or hepatic arterial infusion chemotherapy (HAI), and also clarifying the relationship between these duct injuries and the peribiliary capillary plexus (PBP). These bile duct injuries were found in seven (12.5%) of the 56 consecutive autopsy livers with HCC and a history of TAE or HAI, whereas they were not in the 48 consecutive autopsy livers with HCC but without such a history (p < 0.02). There was a close relation between the areas of TAE and bile duct injuries. These complications were restricted to the intrahepatic large or septal bile ducts. The inner layer vessels of PBP were considerably reduced in the HCC cases with a history of TAE or HAI, irrespective of these bile duct injuries. We concluded that bile duct necrosis or biloma was not uncommon in cirrhotic livers with HCC after TAE or HAI, and that TAE or HAI might cause the reduction of the inner layer vessels of PBP which may be necessary but was insufficient for the induction of bile duct necrosis or biloma.
Adolescent↗
High-risk groups and screening strategies for early detection of hepatocellular carcinoma in patients with chronic liver disease.
Characteristics of high-risk groups for hepatocellular carcinoma (HCC) in Japan were studied to establish screening strategies for early detection of the tumor. Some 93% of patients with HCC were associated with chronic liver disease. On the other hand, 67% of patients with liver cirrhosis had HCC at autopsy. Most were related to current hepatitis virus infection. An analysis of risk factors among 120 patients with chronic hepatitis revealed that age and histological findings were independent risk factors, while HBsAg, anti-HCV, sex, history of heavy drinking, history of blood transfusion were not independent risk factors. Multivariate analysis of 239 patients with liver cirrhosis demonstrated that age, positivity for HBsAg and/or anti-HCV, family history of liver disease, hepatic reserve, and a history of radical resection were independent factors related to the development of HCC. A screening schedule for cirrhotic patients was established in accordance with these results; ultrasonography was done every three months, and tumor markers measured every two months. The screening strategy proved to be effective for the early detection of HCC and improvement of the prognosis.
Aged↗
[Experimental study on the usefulness of the autoperfusion balloon catheter in maintaining the blood supply to the distal organs].
Autoperfusion Balloon Catheters (APBC) were inserted into the renal arteries of seven dogs for about two and a half hours. Abdominal aortography showed renal arterial flow of the kidney obstructed by APBC. Macroscopic and microscopic examination revealed no significant changes in the resected specimen. It is concluded that APBC is useful in cases of proximal arterial occlusion by maintaining the blood supply to the distal organs for relatively short periods and that it can be used for the treatment of rupture of arteries which feed critical organs.
Animals↗
Usefulness of ultrasonography and Doppler color flow imaging in the diagnosis of internal jugular phlebectasia.
A 20-year-old woman presented to our hospital for investigation of a left neck mass. Ultrasonographic examination of the jugular mass demonstrated an echo-free space, the caliber of which markedly increased when the patient shifted from the sitting to the recumbent position or performed a Valsalva maneuver. On color Doppler flow imaging, a slow flow signal flowing in the direction opposite to that of the common carotid artery was found within this space. Ultrasonography and color Doppler flow imaging thus proved to be useful for correctly diagnosing internal jugular phlebectasia.
Adult↗
Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma: a morphometric study.
Vascular supply of adenomatous hyperplasia (AH) of the liver, a preneoplastic or early neoplastic lesion of hepatocellular carcinoma (HCC), and that of HCC were morphometrically examined. Seventy-three nodules of AH were divided into 43 ordinary and 30 atypical AHs. The latter showed a variety of hepatocellular atypias that were, however, insufficient to make a diagnosis of HCC, while the former lacked such atypias. Arteries were slightly more numerous and portal veins were slightly less frequent in both ordinary and atypical AHs compared with the surrounding liver. In ordinary AHs, cumulative areas of arterial lumen and portovenous lumen were almost equal to or less than those in the surrounding liver in two thirds of our cases. The cumulative area of arterial lumen was equal to, and that of portovenous lumen was less than, the cumulative area in the surrounding liver in the remaining one third of our cases. In a majority of atypical AHs, the cumulative area of arterial lumen was equal to, and that of portovenous lumen was less than, the cumulative area in the surrounding liver. In most HCC nodules, the number and cumulative luminal area of arteries were much more, and those of portal veins were much less, than the number and cumulative area in the surrounding liver. The relative number and cumulative luminal area of abnormal arteries compared with all arteries showed a stepwise increase in the following order: ordinary AH (20.7% and 17.5%), atypical AH (46.8% and 52.5%), and HCC (93.6% and 92.0%). These data suggest that ordinary AH, atypical AH, and HCC are different in vascular supply, and that these differences may reflect sequential changes in the hemodynamic state during hepatocarcinogenesis.
Aged↗
Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging.
The potential of superparamagnetic ferrite particles in magnetic resonance (MR) imaging to help differentiate between hyperplastic nodular lesions in the liver and hepatocellular carcinomas was evaluated with chemically induced liver tumors in cirrhotic rats. Ferrite particles decreased the signal intensity of hyperplastic nodules but not that of hepatocellular carcinomas, and stainable iron was found in the former but not in the latter with Prussian blue iron stain. T1-weighted spin-echo images made little contribution to the differentiation between these two lesions, while T2-weighted spin-echo images were effective for this purpose, since ferrite particles cause T2 shortening. Ferrite-enhanced MR imaging may be useful in differentiating these two lesion types according to their signal intensity changes on images, because Kupffer cells are present in hyperplastic nodular lesions but rarely in hepatocellular carcinomas.
Animals↗
Hepatocellular carcinoma: correlation of MR imaging and histopathologic findings.
Seventy-two histologically proved nodular hepatocellular carcinomas (HCCs) were studied with magnetic resonance (MR) imaging at 1.5 T. Capsules were present in 56 of the 72 tumors. Thirty-seven capsules were depicted on T1-weighted spin-echo MR images, and 16 were depicted on T2-weighted MR images. Visualization was dependent on thickness and structure of the capsules. Of the 72 tumors, 36 had a mosaic pattern. A mosaic pattern was visualized in 12 of the 36 tumors on T1-weighted images and in 27 of the 36 tumors on T2-weighted images. Six tumors were determined to be histologic grade 1, and all were hyperintense on T1-weighted images, regardless of whether intracellular fat deposits were present. Four of the six grade 1 tumors were isointense on T2-weighted images. In contrast, grades 2 and 3 tumors had various signal intensities on T1-weighted images and most were hyperintense on T2-weighted images. Twenty-one of 32 tumors (66%) with focal areas of increased signal intensity on T2-weighted images had intratumoral dilated sinusoids at histologic examination.
Adolescent↗
Pathogenicity of porcine hemagglutinating encephalomyelitis virus for mouse and guinea pig.
Explore the source record for details and available documents.
Age Factors↗
Macronodular tuberculoma of the liver: CT and MR findings.
Explore the source record for details and available documents.
Aged↗
Focal ischemic necrosis of the liver associated with cirrhosis: radiologic findings.
Explore the source record for details and available documents.
Aged↗
[Prevention of postoperative recurrence of hepatocellular carcinoma by adjuvant locoregional chemotherapy].
Postoperative adjuvant locoregional chemotherapy was performed on patients who underwent hepatic resection for hepatocellular carcinoma with permeation of tumor into portal vein and/or into hepatic vein and/or intrahepatic metastasis to prevent recurrence. Twenty patients received intra-hepato-arterial infusion of chemotherapeutic drugs or Lipiodol, or transcatheter arterial embolization as adjuvant therapy, and 25 patients did not receive the therapy. There was no significant difference in the recurrence rate between the two groups, and disease-free-survival would not be improved significantly by adjuvant therapy. But the disease-free-survival was improved in patients who underwent relative noncurative hepatectomies. Median duration from the hepatic resection to the recurrence was prolonged by adjuvant therapy, but no significant difference was noted between the two groups. Serious hepatic injury was a side effect of adjuvant therapy in one patient. Therefore great care was necessary when performing the therapy. Further study on choice of the drugs and methods was considered necessary to obtain more effective therapy.
Antineoplastic Combined Chemotherapy Protocols↗