[The changes of the OEP-HA titer in the sera of mice challenged with Pseudomonas aeruginosa and in the phagocytic system of macrophages in vitro (author's transl)].
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Biomedical subjects
Publications and source records attributed to O Kunii.
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A sixty-three years old female patient with subacute bacterial endocarditis was treated with clindamycin-2-phosphate parenterally, because she had a history of hypersensitive reaction to penicillins. She had received erythromycin, cephaloridine and cephalexin previously, but had no bacteriological response. When clindamycin-2-phosphate was given intramuscularly, the bacteremia disappeared for the first time. However, after the cessation of this treatment Streptococcus viridans grew in her blood again. It was suggested that this drug was bacteriostatic rather than bactericidal. During this therapy, local tenderness was noticed at the injected sites and a transient maculopapular rash developed which resolved in a few days.
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The absorption and excretion of a new doxycycline solution for intravenous use (DOTC iv) were studied with the following results. 1. Serum levels following one shot intravenous injection of DOTC iv in glucose solution showed a good dose-response comparable with that of the same dose injection of pyrrolidinomethyltetracycline (PRM-TC). The urinary excretion was also examined. In 200 mg injection, nausea, general warm feeling, odor in mouth and tongue numbness were complained. 2. When DOTC iv was injected intramuscularly, the serum level did not reach the peak value and low level continued for a long time. Moderate local pain was complained at the site of injection. 3. The serum level following drip infection of DOTC dry fill showed a dose-response as well. The local vein tolerated well. 4. No abnormalities were found in clinical and laboratory examinations in all volunteers.
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INTRODUCTION: The need for the application of international standards has been evolving over the last decade. Consistency is needed not just in how we respond, but in when we respond. The discussions in this theme reflected on the progress of standard setting both at the local level and internationally. METHODS: Details of the methods used are provided in the introductory paper. The chairs moderated all presentations and produced a summary that was presented to an assembly of all of the delegates. The chairs then presided over a workshop that resulted in the generation of a set of action plans that then were reported to the collective group of all delegates. RESULTS: Main points developed during the presentations and discussion included: (1) requirement of standards of care for ALL disasters and core parameters, (2) process and procedure is best when there is interagency collaboration and coordination, (3) problems in disasters are management-related, not skill-related, and (4) standards of care must encompass evolving emergencies (e.g., emerging diseases, landmines). DISCUSSION: The action plans for Theme 5 included: (1) develop positions of standards for management, health and public health, education and training, research, psychosocial aspects, and disaster plans; (2) advocate for actions and task forces to deal with evolving and emerging disasters, terrorism, landmines, and emerging infections; (3) proactively work to advocate and facilitate the multidisciplinary and multiorganizational requirements for disaster management; and (4) develop a resource list of interdisciplinary institutions and activities organized by country and topic including the design and maintenance of a website. CONCLUSIONS: There is a clear need for international standards for the management of disasters. Positions and advocacy for these positions are required to define and implement such standards.