In a series 40 subjects without manifest vascular disorders received 1000 mg Calcium dobesilate (Doxium). Before and 3 hours after application the viscoelasticity of whole blood as well as plasma viscosity and the hematocrit were determined. The statistical analysis was performed by Wilcoxon-test. The viscosity of whole blood and the hematocrit decreased with a significance of p less than or equal to 0.001, whereas the elasticity decreased in a significance manner of p less than or equal to 0.01. Plasma viscosity remained uncharged. The results show an effect of hemodilution, which could be very important for treatment of hyperviscosity.

Adult↗

PubMed1988

Calcium dobesilate and its effects on hemorheology and microcirculation.

In series, 50 patients suffering from cerebral (n = 33) and peripheral (n = 17) diseases were treated with 3 x 500 mg calcium dobesilate (Doxium) per day. Before onset of therapy and after 14 days the viscoelasticity of whole blood and plasma as well as hematocrit and microcirculation at the finger pad were measured. Viscoelasticity of whole blood, plasma and hematocrit decreased in a significant manner (p less than or equal to 0.001), while microcirculation increased significantly (p less than or equal to 0.001). The results justify the application of calciumdobesilate for ischemic diseases with elevated viscosity.

Adult↗

PubMed1988

[Hemorheologic monitoring of thyroid cancer patients treated with mega-radioiodine therapy].

Explore the source record for details and available documents.

Blood Viscosity↗

PubMed1988

[Value of pre- and postoperative thyroid scintigraphy using Tl-201].

Explore the source record for details and available documents.

Humans↗

PubMed1987

Radioelectrophoresis for determination of thyroid hormone binding abnormalities in human serum.

This paper describes a rapid and accurate method for determining binding abilities of thyroid hormones to their corresponding serum proteins: prealbumin, albumin and thyroxine binding globulin. A tube cell agarose gel electrophoresis is used with radioactive labelled triiodothyronine or thyroxine. The distribution curve shows characteristic peaks for prealbumin, albumin and thyroxine binding globulin. A collective of 60 euthyroid thyroid-healthy persons was examined, and the following reference values for the binding of thyroxine to its binding proteins were found: The percentage binding of thyroxine to the prealbumin fraction is 21 to 33%, to the albumin fraction 10 to 15% and to the thyroxine binding globulin fraction 54 to 66%. In a group of 220 patients with suspected thyroid hormone binding abnormalities there were 42 cases of albumin-associated hyperthyroxinaemia, 5 cases of prealbumin-associated hyperthyroxinaemia and 2 cases of thyroxine binding globulin deficiency. In another group of 35 patients with suspected antibodies against thyroid hormones one patient showed antibodies against triiodothyronine.

Blood Proteins↗

PubMed1987

[Detection of thyroid hormone antibodies using a radial immunodiffusion method].

T3 and T4 autoantibodies just as protein binding anomalies are the cause of discrepancies of thyroid hormone assays as against actual thyroid function. Depending on the separation techniques used, autoantibodies lead to false low or high T3 or T4 values. A series of 105 preselected thyroid patients was investigated as to the presence of T3 and T4 autoantibodies. Only in one of these patients T3 autoantibodies could be documented as cause for elevated fT3 values in otherwise euthyroid function (clinically euthyroid, positive TRH/TSH response, euthyroid peripheral tissue parameters). The remaining 104 subjects showed neither T4 nor T3 autoantibodies. The method of investigation developed for final diagnosis of T4 and T3 autoantibodies was done by a radial immune diffusion technique. Here the serum sample was incubated for 12 hours at room temperature with radioactive labelled T3 or T4, then applied on to an antiIgG immune diffusion disc. The radioactivity of the punched precipitation area is measured. This method is quick and easily carried out and highly suitable as screening method.

Aged↗

PubMed1987

[Economical and rational in vivo and in vitro diagnosis in Basedow hyperthyroidism].

Immunogenic hyperthyroidism (Graves' disease) is a life-long ailment. A widespread diagnostic evaluation is essential for unbiased initial values prior to therapy. The major goals of initial investigation are to determine a functional disturbance of the organ, its pathogenesis and morphology. Even a suppressed ultrasensitive bTSH value represents no evidence of overt hyperthyroidism; a positive diagnosis can only be established by the additional presence of increased parameters of circulating free thyroid hormones (fT3, fT4). Evidence of any immunogenic pathogenesis is given by positive thyroid antibody values (TRAK, MAK, TAK). Moreover, the use of sonography (with poor diffuse echo and increased thyroid depth) as well as Tc-99m scan indicating primary autonomy, thyroxine induced hyperthyroidism or painless thyroiditis) may both prove rather useful in a rational and economical diagnosis of Graves' disease.

Autoantibodies↗

PubMed1987

[Antibodies to Yersinia enterocolitica in immunogenic thyroid diseases].

In 1976 Shenkman et al. revealed that in patients with thyroid disorders antibodies against Yersinia enterocolitica could be demonstrated in increased frequency. In 1983 Ingbar et al. first established that the gram-negative bacterium Yersinia enterocolitica shows on its surface saturable binding sites for thyrotropin (TSH). If such binding sites resemble immunologically human TSH receptors this would indicate that TSH receptor antibodies could be produced in selected individuals having been infected with bacteria showing TSH receptors. The aim of our study was to compare the incidence of antibodies against Yersinia enterocolitica in two groups of thyroid disorders which are either immunogenic (Graves' disease and Hashimoto thyroiditis) or non-immunogenic (toxic adenomas, endemic goitre). In our series of 111 patients antibodies against Yersinia enterocolitica were demonstrated in a significantly higher percentage (36.3%) in patients suffering from immunogenic than in patients with non-immunogenic thyroid disorders (19.6%). The antibody titres were mainly directed towards Yersinia subtypes 8 and 3. It may, therefore, be assumed that the gram-negative bacterium Yersinia enterocolitica may have an active part in triggering immunogenic thyroid diseases such as Graves' disease or Hashimoto thyroiditis.

Adolescent↗

PubMed1986

[Visual fixation tonometry as an aid in the early diagnosis of endocrine ophthalmopathy].

In some cases of autoimmunogenic hyperthyroidism an endocrine ophthalmopathy is found, but it is difficult to diagnose Graves' disease in early stages. Even before the occurrence of measurable morphological changes (measured by sonography and computed tomography of the orbit and eye muscles) short positional intraocular pressure changes are found in 64.5% of cases with autoimmunogenic dysthyreosis. These pressure changes are detected by positional applanation tonometry. These findings admit the conclusion that with the method described not only early detection of ocular signs associated with thyroid disease is possible, but also early differentiation between autoimmunogenic and nonimmunogenic thyroid disorders.

Eye Movements↗

PubMed1986

[Prealbumin-associated hyperthyroxinemia].

Prealbumin associated hyperthyroxinaemia represents a rare but important protein binding anomaly, causing difficulties in differential diagnostics. This anomaly is based on a variant prealbumin showing an increased affinity to T4 and rT3 and in some cases also when using T4 analogue tracers. The condition of the patient is clinically euthyroid which is confirmed by a normal bTSH level, a normal response to TRH, and peripheral parameters (BMR, ASR, STI, SHBG) in the euthyroid range. This paper describes the diagnostic difficulties in a 45-year-old male pointing out the significance of precise laboratory determination of prealbumin associated hyperthyroxinaemia in order to avoid misdiagnosis and wrong treatment.

Diagnosis, Differential↗

PubMed1986

[Sonographically established thyroid volume in 7- to 11-year-old children].

Since the introduction of thyroid sonography as a routine method for thyroid investigation sonographically determined volumes are being increasingly used for comparative studies concerning the incidence of goitre. The main purpose of this paper is to establish mean values in seven to eleven years old children with sufficient iodine supply as evaluated by urine iodine excretion. Thus it was possible to fix standard mean values to be applied also in non endemic areas. The average thyroid volume of seven to eleven years old subjects was established to be 4.89 +/- 1.83 ml. Additionally the significance of palpatory findings in this age group was compared with sonographic values. The palpation alone especially in the age mentioned is mostly unsuitable in order to differentiate between normals and early goitre development. Consequently sonography is essential in epidemiological studies of goitre incidence.

Austria↗

PubMed1986

[Treatment of inappropriate TSH secretion with Triac].

Diagnostically one differentiates neoplastic and non neoplastic forms of inappropriate TSH-secretion characterized by increased TSH levels with a parallel rise in peripheral thyroid hormone parameters. Surgery is the treatment of choice in cases of TSH secreting pituitary tumors. In this paper different regims of medication are described in a patient with non neoplastic inappropriate TSH secretion. This 39-year-old woman underwent unsuccessful therapy both with bromocriptine and d-thyroxine. Finally a persistent (so far 4 months) TSH-suppression treatment with TRIAC brought lasting success to the same patient.

Adult↗

PubMed1986

[Diagnosis of peripheral thyroid hormone effect using sex hormone-binding globulin (SHBG) and systolic time intervals (STI)].

Only in rare cases with peripheral resistance to thyroid hormones, low T3 syndrome and inappropriate TSH secretion a laboratory determination of the effects of thyroid hormones on peripheral organs such as BMR, Achilles sinew reflex, cholesterol, SHBG, STI etc. is necessary. It was demonstrated that serum concentration of SHBG offered a clear and reliable parameter of the effects of thyroid hormones on liver cells. In a group of 31 patients with overt hyperthyroidism the level of SHBG being 136.5 nmol@l was significantly higher (p less than 0.001) than in control patients showing 36.3 nmol/l SHBG. The hypothyroid group (32 patients) showed a rather significant reduction (p less than 0.01) in SHBG level with a median of 27.5 nmol/l. Among the systolic time intervals the preejection period (PEP) and the LVET/PEP ratio were the most striking parameters. In the hyperthyroid group there was a highly significant shorter interval of PEP (p less than 0.001) and a significant rise of the LVET/PEP ratio (p less than 0.01) compared with the control patients. In the hypothyroid group a hardly perceptible extension of PEP (p less than 0.01) was observed, but a highly significant decrease of the LVET/PEP ratio (p less than 0.001) could be demonstrated.

Cardiac Output↗