Biomedical subjects
Nigel Williams
Publications and source records attributed to Nigel Williams.
Sun clocks in as migration key.
The mechanisms by which some animals are able to achieve astonishing feats of migration have often eluded researchers because of the difficulty of designing suitable experiments. Two Canadian researchers believe they now have a set-up to throw light on the flight of the monarch butterfly. Nigel Williams reports.
Biodiversity challenge to funding priorities.
Ten years after the key Earth Summit in Rio, a key group of influential politicians in Britain are flagging up the need to support research into taxonomy as a basis for biodiversity studies ahead of this summer's meeting in South Africa. Nigel Williams reports.
Testing notions of global ecology.
It's clear that one thing that would boost scientific input to the issue of biodiversity would be evidence that researchers can model effectively the large-scale behaviour of ecosystems. A new issue of a prestigious journal aims to explore just that. Nigel Williams reports.
Abbey ambitions to celebrate home of genetics.
A century and a half after the ground-breaking work by Gregor Mendel in establishing the foundation of genetics, efforts are under way to develop a fitting commemoration of his work at his abbey home in Brno. Nigel Williams reports.
Treatment fillip for gene therapy ambitions.
Explore the source record for details and available documents.
Feature: Europe ramps up its research goals.
Explore the source record for details and available documents.
Capturing public unease.
Explore the source record for details and available documents.
Full genome screen for Alzheimer disease: stage II analysis.
We performed a two-stage genome screen to search for novel risk factors for late-onset Alzheimer disease (AD). The first stage involved genotyping 292 affected sibling pairs using 237 markers spaced at approximately 20 cM intervals throughout the genome. In the second stage, we genotyped 451 affected sibling pairs (ASPs) with an additional 91 markers, in the 16 regions where the multipoint LOD score was greater than 1 in stage I. Ten regions maintained LOD scores in excess of 1 in stage II, on chromosomes 1 (peak B), 5, 6, 9 (peaks A and B), 10, 12, 19, 21, and X. Our strongest evidence for linkage was on chromosome 10, where we obtained a peak multipoint LOD score (MLS) of 3.9. The linked region on chromosome 10 spans approximately 44 cM from D10S1426 (59 cM) to D10S2327 (103 cM). To narrow this region, we tested for linkage disequilibrium with several of the stage II microsatellite markers. Of the seven markers we tested in family-based and case control samples, the only nominally positive association we found was with the 167 bp allele of marker D10S1217 (chi-square=7.11, P=0.045, df=1).
Desktop boost to anthrax studies.
Explore the source record for details and available documents.
Features: Franklin prize for women scientists.
Explore the source record for details and available documents.
Downside of assessment success.
Explore the source record for details and available documents.
Europe grapples with cloning headaches.
Explore the source record for details and available documents.
London home for Crick archive.
Unprecedented access to the archives of Francis Crick, just before the 50th anniversary next year of his famous paper co-authored with James Watson on the proposed double helix structure of DNA, looks set to go ahead. Nigel Williams reports.