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Biomedical subjects

N W Thompson

Publications and source records attributed to N W Thompson.

223 records · Page 13Linked to original sources
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Coagulation studies after transfusion of hydroxyethyl starch protected frozen blood in primates.

This-study evaluates the effects of the transfusion of frozen-thawed blood protected by hydroxyethyl starch (HES) on shocked monkeys. Particular attention is directed toward the study of coagulation in view of previous reports of coagulopathies caused by hydroxyethyl starch. In vivo studies were done in 13 shocked monkeys that received either homologous or autologous blood which had been frozen and thawed with 14 per cent HES as the cryoprotective agent. Multiple coagulation studies were obtained on the monkeys, and histopathological evaluations were performed. There was no evidence of increased bleeding or bleeding tendencies in the monkeys transfused with HES preserved blood. Serum chemistry values were not significantly altered in animals that received blood preserved by HES nor in those that received large quantities of HES alone. Histopathological examination of biopsy and autopsy material demonstrated no changes which could be related to hydroxyethyl starch.

Animals↗
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Clinicopathological peculiarities in parathyroid disease with hypercalcaemic crisis.

OBJECTIVE: To draw attention to some hitherto unnoticed clinicopathological aspects of primary hyperparathyroidism in patients who develop hypercalcaemic crisis. DESIGN: Retrospective review of records and histopathological archive material. SETTING: University hospital. SUBJECTS: 54 patients treated for primary hyperparathyroidism with hypercalcaemic crisis between 1961 and 1988. MAIN OUTCOME MEASURES: Correlation of age, serum calcium concentration, histopathological appearance and size of tumours associated with hypercalcaemic crisis. RESULTS: 11/54 (20%) of the patients with hypercalcaemic crisis were younger than 40 years of age. Among 460 patients treated at the same hospital for primary hyperparathyroidism without hypercalcaemic crisis, 23 (5%) belonged to the same age category (p less than 0.001). There was no difference between the two groups of patients regarding histopathological characteristics, with the exception of mitotic activity which was remarkably high in some benign lesions causing hypercalcaemic crisis. The correlation between tumour size and degree of hypercalcaemia was poor, and one-third of the adenomas did not exceed 2 cm in diameter. CONCLUSIONS: Young age is a risk factor regarding the development of hypercalcaemic crisis in primary hyperparathyroidism; the proportions of the pathological entities causing hypercalcaemic crisis do not differ markedly from other cases of primary hyperparathyroidism; the correlation between adenoma size and degree of hypercalcaemia is poor; oxyphil adenomas are as likely to be associated with hypercalcaemic crisis as other types of parathyroid adenoma; and some benign parathyroid lesions associated with hypercalcaemic crisis (hyperplastic glands as well as adenomas) show high mitotic activity.

Adenoma↗