Biomedical subjects

N V Novikova

Publications and source records attributed to N V Novikova.

38 records · Page 3Linked to original sources

PubMedDate not supplied

[Experimental analysis of embichin interaction with human serum albumin].

Study of embichin binding to human serum albumin in vitro by gel chromatography and fluorescence has shown that embichin is bound to human serum albumin with an association constant of 3.3 x 10(3) M-1. Interaction of embichin and albumin, that is reversible in the initial stages, transforms to irreversible on long-term contact of the protein with the drug. Experiments with cell culture indicate that the interaction with albumin potentiates the cytotoxic action of embichin.

Alkylation↗

PubMedDate not supplied

[The action of the alkanol ammonium salts of aroxyacetic acids on the thrombocyte aggregation process].

Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.

Acetates↗