Biomedical subjects
Publications and source records attributed to N V Novikova.
Humoral immunity initially affected in patients with osteoarthrosis returns to normal under the influence of a multiple-modality treatment involving application of sulphide moor in combination with sodium chloride baths.
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It was shown in experiments on rabbits that dimethoxyphosphates of rare-earth elements injected intravenously displayed a marked anticoagulant activity. The highest effect was produced by compounds of neodymium, holmium, terbium, europium, thulium, dysprosium, and erbium.
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It was shown in experiments with three types of cells (dog red cells, hepatic cells of newborn Wistar rats, and culture of the renal epithelium of Vero monkeys) that cadmium in complexes with dimercaptoethanol penetrates the cells in an 8-33-fold greater amounts than free cations of metal. Unithiol increases cadmium penetration in the cells by 1.6-3 times only. The strength of cadmium binding with dimercaptopropranolol in the cells is greater than that with unithiol and free cations. Albumin limits penetration of free cations of cadmium and of complexes with dimercaptothiol to a greater degree than that of cadmium complexes with unithiols. The reasons for the differences revealed are discussed.
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The authors analyze the results of research on clinical pharmacology carried out at various institutions in this country. The overwhelming majority of works are concerned with clinical studies on the pharmacodynamics and pharmacokinetics of the drugs, their interaction, and detection of drug side effects. Special attention is paid to the improvement of the methods for determination of the pharmacological agents in biological fluids, and to the design of the maximally adequate parameters of assessing the pharmacodynamics of the main groups of the drugs. Considerable part of investigations is devoted to clinical pharmacogenetics, chronopharmacology, age pharmacology, prediction of the drug effects, approaches to the extrapolation of experimental data to the clinical trials of the drugs. The authors also provide evidence on the system of clinical trials of new drugs and detection of untoward effects of the medicines used.