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Biomedical subjects

N Soehendra

Publications and source records attributed to N Soehendra.

At least 199 records · Page 11Linked to original sources

[The diagnosis of annular pancreas (author's transl)].

Annular pancreas is a rare congenital malformation of the gut; frequently it becomes manifest in adult life. The clinical picture and radiological appearances are dominated by stenosis of the duodenum. The only method for diagnosing annular pancreas up to the present was the barium meal. Its diagnostic accuracy, however, is limited. A knowledge of the characteristic radiological appearances is helpful unless other abnormalities confuse the interpretation. E.R.C.P. is an important advance in diagnosis. The diagnosis of annular pancreas can be made by demonstrating an accessory duct system. The literature is reviewed.

Adult↗

[Duodenal cancer. A clinical-pathological study].

Seven primary carcinomas of the duodenum were observed from 1973 to 1976 at the University Hospital Hamburg; four in females and three in males with an age between 32 and 69 years of age. The interval between the first symptoms (epigastric pain, jaundice, pruritus, diarrhea, and loss of weight) and surgical therapy (duodeno-pancreatectomy) averaged four months. All carcinomas were resected radically from the macroscopic (intraoperative) aspect as well as from the histological findings. Local tumour recurrences which proved fatal occurred in five patients within nine to twenty-one months. One patient died of peritonitis and another of pancreatitis. The diagnostic mode has been changed since the introduction of endoscopy and retrograde cholangio-pancreaticography (ERCP). The consistent inclusion of the duodenum in routine gastroscopy leads to the hope that more carcinomas of the duodenum can be detected early.

Adult↗

[Diagnostic prerequisites of hyperselective vagotomy (author's transl)].

On admission to hospital the radiologic diagnosis of ulcer in 640 patients (407 duodenal ulcer, 233 gastric ulcer) was supplemented by means of gastroduodenoscopy in 207 cases; ERP was performed in few cases. In 51 patients with the initial radiologic diagnosis of duodenal and 28 gastric ulcer (12,3%) decisive alterations of the operative tactics based on the initial diagnosis were made. The differences in the findings neither discredit nor favor one or the other diagnostic procedure. The necessary collaboration between radiologists, endoscopists and surgeons is based, as usual, on technical perfection. When no such prerequisite is available the radiologic diagnosis should be optimized or supplemented through an endoscopic examination.

Duodenal Ulcer↗

[Annular pancreas (author's transl].

Eight cases of annular pancreas treated at the University Hospital of Hamburg between 1964 to 1977 are presented. In adults, the disease follows the pattern of chronic duodenal obstruction being often asymptomatic unless complications such as peptic ulceration, acute pancreatitis or bile duct obstruction occur. Preoperative diagnosis is only possible by using endoscopic retrograde pancreatography. Attention is drawn to the frequent co-existence of other malformations of the gastro-intestinal tract. Treatment should consist of relief of any obstruction to the duodenum by a bypass gastrojejunostomy is recommeded in those cases having associated peptic ulcer. The division or resection of the annulus bears the risk of fistula formation. A brief review of the theories of the development of annular pancreas is given.

Adult↗

[The diagnosis of traumatic haemobilia and bilhaemia (author's transl)].

A case of bile passage into the portal vein (bilhaemia) and two cases of haemobilia are reported. The former is a hitherto undescribed complication of liver injury, in the reported case first noted two weeks after trauma. Serum-bilirubin concentration was 560 mg/l (958 mumol/l). Bilhaemia or haemobilia may occur when a fistula has been formed between the bile duct system and the circulatory system, depending on pressure differences between the two. The diagnosis and exact localisation of bilhaemia or haemobilia can be made by endoscopic retrograde cholangiography, a useful complementary test to selective angiography.

Adolescent↗

[Endoscopic retrograde pancreatography (author's transl)].

Endoscopic retrograde pancreatography is indicated in suspected malformations, chronic inflammation, and tumors of the pancreas. It is contraindicated in acute inflammation and severe obstruction of the main duct. The signs of chronic inflammation are deformities of the ductal system and/or intraductal calculi. Diffuse changes with beading were prominent in 51 patients studied. Malignant tumors cause stenosis, obstruction, tapering, or cavernous deformation of the ductal systm. Complete obstruction of the main duct was seen in the majority of 67 patients studied.

Acute Disease↗

New technique for endoscopic treatment of bleeding gastric ulcer.

In two patients with bleeding gastric ulcer hemorrhage could be stopped by submucous infiltration around the lesion without any complication. This simple method using a selfconstructed needle seems to guarantee good results especially in bleeding little arteries. Infiltration was performed with a 1.5% solution of Aethoxysklerol (Kreussler, Wiesbaden-Biebrich) using 3-5 ml totally for treatment.

Adult↗

[Technique, difficulties and results of endoscopic retrograde cholangio-pancreatography (ERCP)].

Endoscopic retrograde cholangio-pancreatography belongs to the diagnostical equipment of gallduct obstruction and obturation. ERCP is indicated if any doubts arise with the usual clinical diagnostic methods, laboratory, or x-ray studies. This paper presents the technique of ERCP and the several steps in its operation: pylorus passage, description and evaluation of the papilla of Vater and insertion of the papilla. Daily practice and patience produce successful work without complications. Rate of complication in 604 ERCP procedures = 2%. No lethal outcome was observed.

Cholangiography↗

[The role of ERCP in the diagnosis and indication for surgical treatment of diseases in the region of the papilla Vateri (author's transl)].

Duodenoscopy with transpapillar examination of biliary and pancreatic ducts has become an important branch in diagnosing gastroenterologic diseases. This will almost guarantee more exact information especially concerning indications and technique in diseases of the biliary tract and pancreas. Better results of operative treatment might be expected in future.

Ampulla of Vater↗

[A special closure system of the gastrointestinal tract of the rat (author's transl)].

As a result of animal experiments, morpho-histologic and surgical findings, the presence of a new closure system of the gastrointestinal tract is described. The mode of action is different from that of all the known muscle sphincters. It is found in the ascending colon of the rat and consists of a specially arranged and adjustable mucosal folds with aunique vascularisation. A functional unit which comosed of a pair of folds and a vascular plexus constitute the valvular mechanism. We, therefore, consider appropriate to call it the Angioplical Closure System. Surgical reversion of even a very small portion of the system causes a lethal ileus.

Ampulla of Vater↗

[Morphology and physiopathology of Billroth I gastroduodenostomy].

97 patients subjected from 1 to 7 years previously to partial gastric resection by gastroduodenostomy (Billroth I) have been studied endoscopically and radiologically. Acid secretion after pentagastrin injection has also been determined. The most frequent mucous alterations identified by endoscopy were erosions in the stomach residue with inflammatory granulation in the anastomosis region. Recurrent ulcers were observed in 3% of cases. Acid secretion was reduced in 87% by comparison with the preoperative picture. The quantity of residual recretion depended on the greater curvature of the residual stomach. Radiological studies highlighted functional modifications indicative of organized motility in the residual stomach and pseudopyloric function at anastomosis level making coordinated draining possible.

Follow-Up Studies↗

[Endoscopical and radiological studies after papillotomy (author's transl)].

The paper deals with a controlled study concerning 36 patients who underwent surgical papillotomy. Cholangiographic examinations were performed by infusion and endoscopic retrograde instillation, in ten patients additional percutaneaus "blind" biopsy of the liver. Some new remarkable details could be evaluated at the papilla Vateri itself as definite anatomic alteration after papillotomy. Planimetric studies could be added on special details because of the good x-ray-contrasts by endoscopic filling of the biliary tract. With some special reserves the results after surgical papillotomy in 30 controlled persons can be classified as good.

Adult↗

[Morphology and pathophysiology of Billroth I gastro-duodenostomy (author's transl)].

Endoscopic and radiological studies were undertaken in 97 patients who had had a partial gastric resection with gastro-duodenostomy (Billroth I) one to seven years previously. Acid secretion was also analyzed after injection of pentagastrin. The most frequent mucosal changes seen at endoscopy were erosion in the residual stomach, with inflammatory granulation in the region of the anastomosis. Recurrent ulcers were seen in 3%. Acid secretion was reduced by 87% from its pre-operative level. The amount of residual secretion depended on the length of the greater curvature in the residual stomach. Radiological studies revealed functional changes indicating that there is a motility pattern in the residual stomach and a pseudopyloric function at the anastomosis which makes co-ordinated emptying possible.

Follow-Up Studies↗

[Radiation exposure of patients and personnel in the endoscopic retrograde cholangiopancreaticography (author's transl)].

The results of the measurement of radiation protection in 54 patients and the involved personnel exposed to radiation (physician performing the endoscopy and the radiologist) during ERCP were analyzed. The radiation exposure values were relatively low and were within the range of those doses to be expected for gastroenterologic radiodiagnostics. After many years of experience, the radiation exposure for patients and physician can be further reduced. Actual danger from radiation need not be feared for the patient or the exposed personnel. The range of maximum values for radiation exposure set-up in the regulations for x-rays is so broad that, with endoscopic centers need not be decreased. Rather it can still be considerably increased.

Cholangiography↗

[Endoscopy of postoperative hemorrhage in the upper gastrointestinal tract].

In hemorrhages from the upper gastrointestinal tract, emergency endoscopy is becoming more and more significant. Hemorrhages during the early postoperative stage, particularly in abdominal surgery, require particular attention due to the generally difficult postoperative situation. In most instances, intragastral hemorrhages are due to erosions and anastomotic bleeding. A detailed knowledge of the surgery performed may contribute to a quick and successful examination. Among the most important premises for a high rate of correct diagnoses are the experience of the examining physician as well as an early or immediate identification of the indications. In addition to the diagnostic significance, under favorable circumstances endoscopy makes possible definitive or temporary staunching of the bleeding by means of diathermy, laser beam or sclerotization.

Endoscopy↗

[Pancreatic pain: a clinical-experimental study].

In 26 patients endoscopic-radiologic pancreography routinely performed caused severe pain with certain origin from pancreatic glan. Pain could be stopped immediately and with constant effect by lingual application of nitroglycerine. According to these informations we suppose that pancreatic pain is started by vascular reactions and ischemia. The good effect of nitroglycerine is worth a control in patients with common acute pancreatitis.

Endoscopy↗