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Biomedical subjects

N Satz

Publications and source records attributed to N Satz.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Upper abdominal pain].

We report a female patient in whom the false diagnosis of acute pancreatitis was made, based on intensive epigastric pain and a four fold increase of amylase. The normal values for lipase and decreased values for the urinary amylase were suggestive of a constellation of macroamylasemia. Further investigations revealed a fresh ulcer in the bulbus duodeni as cause of the epigastric pain. With a therapy of cimetidine and antacids painlessness could be achieved within few days.

Abdomen, Acute↗
PubMed1989

[Extrapancreatic hyperamylasemia. Diagnostic value of isoamylase and lipase determination].

The P- and S-isoamylase and lipase of 72 patients with extrapancreatic hyperamylasemia were determined and their diagnostic value checked to rule out a pancreatic origin. The hyperenzymemia was generally slight although extremely high values were observed in isolated cases. The increased serum amylase results were more often caused by P-, rather than S-isoamylase, while in 28% of cases lipase was also increased. In lung diseases, anorexia and disorders of the head organs only S-isoamylase was pathologically increased while P-isoamylase and lipase remained normal. In other entities such as liver, stomach and intestinal diseases, functional disorders, acidosis, infections, etc., the isoenzymes and lipase showed a variable tendency to increase. Thus, extrapancreatic hyperamylasemia could not always be identified by detection of isoamylases or with the aid of lipase determinations. Overall, however, lipase more often remained in the normal range and was therefore more useful than determination of the isoamylases in differentiating hyperenzymemia.

Acidosis↗
PubMed1988

[Streptococcus bovis bacteremia and colonic diseases].

Four febrile patients were found to have a bacteraemia or endocarditis caused by Streptococcus bovis. Although there were no gastrointestinal symptoms, polyps in the colon, of a high degree of malignancy, were discovered in three. In the fourth, carcinoma of the colon, requiring resection, was found seven years after Streptococcus bovis endocarditis. The polyps were removed by endoscopy and the Streptococcus bovis infection in all cases cured by penicillin. All four patients had accompanying resistance-lowering illnesses, which favoured microbial invasion.

Adenocarcinoma↗
PubMed1988

[The epidemiology of Borrelia burgdorferi infections. A pilot study from the Männedorf area].

Only a few investigations have been conducted into the incidence of Lyme borreliosis and the prevalence and clinical value of increased antibody titers against Borrelia burgdorferi. We prospectively examined 241 persons and found increased titers in 23 (9.5%); only two of them had a history of Lyme borreliosis. The concentrations of increased IgG-antibody titers in healthy persons were comparable to those in patients with actual Lyme borreliosis. In the latter, IgM-antibodies were frequently absent. Our results suggest an infection rate of about 10% in this region of Switzerland. They further emphasize that the diagnosis of Lyme borreliosis must primarily be established clinically and by exclusion of other etiology.

Adult↗
PubMed1986

[Erythema migrans. The clinical spectrum of Borrelia burgdorferi infection].

17 patients with acute and chronic symptoms of Borrelia burgdorferi infection are described. These cases, which were diagnosed within a short period of time at the Männedorf-Zürich hospital, suggest that Erythema migrans disease is likely to be frequent in Switzerland as well as elsewhere.

Acrodermatitis↗
PubMed1984

On the pathogenesis of pancreatic ascites.

The pancreatic ascites of 2 patients and the drainage fluid collected adjacent to the pancreas postoperatively of 1 of them were analyzed for protein composition and enzyme activity. We did not find a proteolytic activity, especially enzymatically active trypsin and chymotrypsin in these fluids. Immunoreactive (inactive) trypsin was, however, present in rather high concentrations. The drainage fluid changed from an inflammatory exudate to a fluid similar in composition to pancreatic juice later on. Our results indicate that pancreatic ascites consist of a combination of enzyme-rich pancreatic fluid and protein-rich exudate from the inflamed pancreas. No evidence of peritonitis or of proteolytic activity capable of inducing peritonitis was found.

Adult↗
PubMed1983

[Mediastinal pancreatic pseudocysts. Report of 2 cases and review of the literature].

Mediastinal pancreatic pseudocysts are rare complications occurring in the course of pancreatitis. Two patients are described with chronic alcoholic pancreatitis who developed mediastinal pancreatic pseudocysts. The most prominent clinical findings were, respectively, recurrent pericardial and pleural effusions and dysphagia. The elevated amylase values in serum and urine and in the pericardial and pleural effusions pointed to pancreatic disease. The mediastinal pancreatic pseudocysts were found preoperatively by ultrasound and endoscopic retrograde cholangiopancreatography. Surgery was performed. In one case the pseudocyst was treated by external drainage and in the other case by marsupialization into the left pleural space. In each case pancreaticojejunostomy was performed in addition. Etiology, symptoms, diagnosis and therapy in 32 published cases are discussed on the basis of experience with these two patients.

Alcoholism↗
PubMed1983

High amylase content of neoplastic pleural and pericardial effusion probably secondary to amylase producing tumor cells: report of 2 cases.

We report two cases of malignant pleural and pericardial effusion respectively secondary to bronchogenic carcinomas. In both effusions, a significant elevation of the Salivary-type-amylase fraction was found, while the corresponding values were normal in serum and urine. Electronmicroscopy of the malignant tumor cells from the pleural effusion showed typical electron-dense granules, suggesting zymogen granules. It is concluded that the high amylase content of the effusions was due to secretion of S-type-isoamylase by the tumor cells.

Aged↗
PubMed1982

Variations with age of immunoreactive serum trypsin: higher reference ranges in "healthy" elderly people.

According to the literature, the mean values of immunoreactive serum trypsin (IRT) (RIA-gnost Hoechst) in controls vary considerably between 150 and 283 ng/ml. The reasons for these variations are unknown. The purpose of the present investigation was to study the variations of IRT in relation to age in adults. We studied 124 hospital controls, who were without evidence of pancreatic disease or renal insufficiency and who varied in age between 17 and 84 years. Utilizing the kit of Hoechst, IRT was determined in fasting serum specimens. The mean (+/- SD) in patients over 60 years was 469.6 +/- 197.4 ng/ml, in contrast to 309.1 +/- 118.9 ng/ml (30-59 years) and 209.7 +/- 80.7 (less than 30 years). Of cases over 60 years 36.5% had elevated IRT levels above 500 ng/ml. In 25 cases over 60 years no correlation was found between IRT levels and creatinine clearance and in eight of ten cases of this group with high IRT (greater than 500 ng/ml) the serum pancreatic isoamylase levels were normal. The data indicate that in the diagnosis of pancreatic disease the higher reference ranges in the elderly people have to be taken into account. The age-related higher reference ranges seem not to be due to subclinical renal disease nor to clinically evident pancreatic disease.

Adolescent↗
PubMed1980

[Furosemide and metolazone: a highly effective diuretic combination].

The natriuretic and diuretic effects of combined treatment with furosemide and metolazone have been studied quantitatively. 15 hospitalized patients with severe fluid retention who showed no reduction of body weight despite treatment with furosemide received metolazone in addition for 3 days. 11 patients had biventricular heart failure with edema, and 4 had cirrhosis of the liver with ascites. Following the addition of metolazone at a starting dose of 2.5 mg/d, a highly significant increase in diuresis and natriuresis, with a corresponding reduction in body weight, was seen in all patients pretreated with a daily dose of 40-370 mg furosemide (mean 122 mg/d). On the first day of this combined treatment the mean sodium excretion increased from 131 to 303 mval/d (2 p less than 0.01) and the mean urine volume increased from 1677 to 2940 ml/d (2 p less than 0.01). The mean reduction in body weight was 6.1 kg (2 p less than 0.001) within 7 days of continuous treatment. Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention. High doses of furosemide can be avoided in many cases, a factor of particular advantage in ambulatory long term therapy and in patients with decreased kidney function. It may also lower the cost of the therapy. In 3 patients the furosemide dose had to be lowered after metolazone was started, to avoid an excessive negative fluid balance. These cases clearly demonstrate the importance of daily checks on the patient's body weight after starting combined therapy with furosemide and metolazone.

Ascites↗