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Biomedical subjects

N Sakurai

Publications and source records attributed to N Sakurai.

At least 163 records · Page 9Linked to original sources
PubMed1985

Congenital absence of flexor pollicis longus without hypoplasia of thenar muscles.

A 7-year-old girl who was unable to flex her left thumb at the interphalangeal joint proved to have an extremely hypoplastic flexor pollicis longus with normal thenar muscles, which is very rare. The flexor digitorum superficialis of the ring finger was transferred to the inserting portion of the flexor pollicis longus tendon with good results. The patient's cooperation seems to be a factor determining the prognosis.

Child↗
PubMed1984

Evolution of enterovirus type 70: oligonucleotide mapping analysis of RNA genome.

Different isolates of enterovirus type 70 (EV70) taken between 1971 and 1981 were studied by molecular biological methods to elucidate their evolutional change. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that only a few isolates had a slight alteration in mobility in some viral proteins. On the contrary, oligonucleotide mapping of virion RNA could clearly delineate the molecular changes among isolates. The number of base changes of isolates became greater as the years elapsed. In addition, the number of base changes among recent isolates from different areas of the world was much greater than those among early isolates. Thus, when the isolates were arranged three-dimensionally according to the number of base changes between each other, the constellation of the strains gave rise to a conical shape. The central axis of the figure was the time of isolation of the strains. The early isolates clustered near the top of the conical figure and the recent isolates tended to disperse divergently at the bottom. The figure indicated that all EV70 strains were derived from a common ancestor, and its top would be the time of emergence of the original strain. It was estimated to be around 1966, 3 years prior to the first epidemic in Accra, Ghana. From the results, it was presumed that EV70 would have emerged at a single focus in Africa as a novel human virus. After having circulated there for a few years, the virus spread to the other parts of the world. Based on the difference in the oligonucleotide spots between the recent isolates and early isolates, the base changes of EV70 that occurred during 10 years was estimated to be 320, about 4% (0.4% a year on the average) of the bases of the total RNA genome.

Biological Evolution↗
PubMed1984

Mechanisms for development of functional tricuspid regurgitation determined by pulsed Doppler and two-dimensional echocardiography.

Mechanisms for the development of functional tricuspid regurgitation (TR) were studied in 41 patients by ultrasound. The severity of TR was classified into 4 grades according to the extent of the regurgitant signal by pulsed Doppler echocardiography (echo). No TR signal was detected in 11 patients; the grade of TR was 1+ in 9 patients, 2+ in 10, 3+ in 8 and 4+ in 9. Using 2-dimensional echo, the tricuspid anular area was estimated from a horizontal and a sagittal diameter of the anulus, and systolic configurations of the tricuspid valve was observed. The tricuspid anular area corrected for body surface area increased with the grade of TR. Anterior displacement of the tips of the tricuspid leaflets was seen in 10 patients with TR of 2+ or greater severity, and its frequency also increased with the grade of TR. Loss of coaptation was seen in 3 patients with 4+ TR and malaligned coaptation was seen in 4 patients with TR of variable degrees. Tricuspid anular dilatation and anterior displacement of the tricuspid leaflet tips causes a separation between the leaflet tips and appears to be the main mechanisms for the development of functional TR. Malaligned coaptation also plays a role in the development of functional TR.

Echocardiography↗
PubMed1984

[Grading of tricuspid regurgitation by pulsed Doppler echocardiography and liver function tests].

Recently, pulsed Doppler echocardiography has been used for the quantitative evaluation of tricuspid regurgitation (TR). However, there are some problems about the clinical significance of TR diagnosed by Doppler examination probably because of the excellent sensitivity in detecting TR. In the present study, we used liver function tests as an indicator of the visceral damage caused by TR and compared them to the severity of TR estimated by Doppler examination. Forty Doppler examinations were performed in 33 cardiac patients including seven, in which the examinations were repeated because the severity of TR changed during the clinical course. The severity of TR was classified into four grades according to the maximal extent of the regurgitant signal. Abnormal liver function was defined by the abnormalities of at least one of the following six tests: cholinesterase (CHE), gamma-GTP, leucine aminopeptidase (LAP), total bilirubin, alkaline phosphatase and GPT. Abnormal liver function tests were present in one of eight patients without TR, two of 10 with 1 + TR, four of seven with 2 + TR, seven of eight with 3 + TR, and six of seven with 4 + TR. The incidence of abnormal liver function tests increased parallel to the grade of TR and was very frequent in patients with 3 + or 4 + TR. TR diagnosed as greater than 3 + by Doppler examination is considered to have an important clinical significance and an indication of the intensive therapy.

Cholinesterases↗
PubMed1984

[Atrial septal defect associated with an abnormal chamber of the right ventricle: report of a case].

A case of atrial septal defect associated with an abnormal chamber behind the right ventricle, which was heretofore undescribed, was reported. A 41-year-old woman was admitted to our hospital for the evaluation of a heart murmur. A Levine 3/6 ejection systolic murmur and a fixed splitting of the second heart sound were audible. Two-dimensional echocardiography disclosed an atrial septal defect and an abnormal chamber behind the right ventricle. This accessory chamber communicating with the right atrium was separated from the right ventricle by a membranous structure. The motion of this membrane showed a wide excursion just like that of the atrio-ventricular valve. On the M-mode echocardiogram, the anterior tricuspid leaflet and this membrane were recorded simultaneously without intervening septal echoes and this finding was very similar to that obtained in the single ventricle. Cardiac catheterization revealed that the pressure pattern in the abnormal chamber was that of the right atrium but its intracardiac electrocardiogram showed a right ventricular pattern. The complex morphological aspect of this case was confirmed by angiography and surgery. The developmental process of this very unusual anomaly is not clear, but it may be a kind of congenital anomaly related to Ebstein's anomaly.

Adult↗