Biomedical subjects

N R Dunnick

Publications and source records attributed to N R Dunnick.

At least 235 records · Page 13Linked to original sources

PubMed1977

Lymphography in patients with suspected malignancy or fever of unexplained origin.

Forty-four patients underwent bipedal lymphography for evaluation of fever of unexplained origin, or because a malignant tumor (usually lymphoma) was suspected clinically. Extensive prior medical evaluation was inconclusive. The lymphograms were of no apparent value in detecting the etiology of the illness. Reactive follicular hyperplasia was frequently seen and sometimes simulated lymphoma on the lymphogram. The primary value of lymphography in such cases is as an aid in planning biopsy and surgery.

Adult↗

PubMed1977

Pediatric lymphography: performance, interpretation, and accuracy in 193 consecutive children.

Experience with 193 children 15 years of age or less who were referred for pedal lymphography over the past 11 1/2 years was reviewed. Successful bilateral lymphatic cannulation was obtained in 94% of cases; in only 2% was the study a bilateral failure. No significant complications or permanent sequelae were encountered. Lymphographic-histologic correlation in 94 children yielded an overall accuracy rate of 95% (specificity, 99%; sensitivity, 80%). Interpretative aspects were similar to that in adults; however, the frequent presence of reactive hyperplasia in childhood was noted. These results suggest that lymphography can be successfully and safely performed in children and that its diagnostic accuracy is at least as high as in adults.

Adolescent↗

PubMed1977

Clinical and surgical (laparotomy) evaluation of patients with non-Hodgkin's lymphomas.

A consecutive unselected series of 423 patients with non-Hodgkin's lymphomas was staged prospectively at the Stanford Medical Center between June 1971 and June 1976. The histopathologic classification of Rappaport was used exclusively. Staging laparotomies were performed in 197 of the patients, but another 226 patients were excluded from the staging procedure for a variety of reasons, including stage IV involvement, poor surgical risk, and diagnostic celiotomy before referral to Stanford. Gastrointestinal, splenic, bone marrow, hepatic, and mesenteric lymph node involvement was very common in these patients, whereas systemic symptoms and mediastinal sites of disease were less frequently noted. After staging laparotomy, 15 patients (8%) were downstaged to a lesser extent of involvement while 62 (31%) were upstaged, primarily from clinical stage III to pathologic stage IV. Correlations were made between clinical and pathologic staging and the sites of involvement were compared between those with nodular and those with diffuse lymphomas. The accuracy of diagnostic radiologic procedures was also assessed. Although it is valuable in sequentially determining the extent of subdiaphragmatic involvement by lymphomas, we believe that staging laparotomy should still be regarded as a research procedure which will be undertaken only as indicated in centers of clinical research.

Adolescent↗

PubMed1977

Whole body computed tomography in the diagnosis of abdominal and thoracic malignancy: review of 600 cases.

Whole-body computed tomography (CT) was performed on 600 patients with known or suspected malignancy at the National Institutes of Health. This new diagnostic modality utilizes a finely columnated X-ray source mounted opposite a computer-linked detector bank to generate anatomic cross-sectional images of the body part being scanned. CT proved valuable in defining many pathologic processes and was, at times, deemed the only test short of exploratory surgery that yielded diagnostic information. This latter benefit was most acutely emphasized in lesions affecting the retroperitoneum, adrenal glands, pelvis, liver, and immediate subpleural pulmonary parenchyma.

Abdominal Neoplasms↗

PubMed1976

Rapid onset of pulmonary infiltration due to histiocytic lymphoma.

Five cases demonstrating the rapid onset of pulmonary infiltrates due to hystiocytic lymphoma are presented. In four cases the pulmonary infiltrate occurred at the time of initial presentation and the fifth case occurred 2 1/2 months after the original diagnosis. The radiographic manifestations are nonspecific. Lung biopsy, open or closed, is needed to confirm the diagnosis before initating appropriate therapy.

Adolescent↗

PubMed1976

Multiple "bull's-eye" lesions in gastric lymphoma.

Three adolescent patients with multiple gastric target lesions and gastric lymphoma are reported. Each had either histiocytic or poorly differentiated lymphoma. The literature was reviewed to ascertain whether multiple gastric lymphomatous target lesions were confined to adolescent patients or to patients with a particular histologic subtype. Review of 119 cases in the literature did not support either hypothesis.

Adolescent↗

PubMed1976

Radiographic manifestations of malignant histiocytosis.

Twenty-six cases of histologically proven malignant histiocytosis are presented. Patient ages ranged from 20 months to 82 years, and a 10:3 male preponderance was seen. Clinical presentation is similar to that of malignant lymphoma and leukemia; histologic differentiation is required. The frequency of intrathoracic involvement at the time of presentation is similar to that of non-Hodgkin's lymphoma. Retroperitoneal lymph node invasion was readily seen on five of the eight lymphograms performed. Hepatosplenomegaly was a common finding, and three of the patients had evidence of bone involvement during the course of their illness. While there are no radiographic findings specific to malignant histiocytosis, the presence of hepatomegaly should suggest this possibility. The establishment of the correct diagnosis is important to guide choices in chemotherapy.

Adolescent↗

PubMed1975

Arteriographic Manifestations of Ganglioneuromas.

The angiographic finding in four cases of ganglioneuroma are described. In all four cases a large vascular mass was demonstrated angiographically. The vessels supplying the tumors varied, depending on the location of the mass. Stretching and displacement of adjacent opacified vessels helped define the extent of the tumor. Abundant neovascularity was present with serpiginous vessels tending to cluster in nodular areas, with adjacent avascular areas.

Adult↗

PubMed1975

Repeat Lymphography in Non-Hodgkin's Lymphoma.

Thirty-nine patients with non-Hodgkin's lymphoma underwent repeat lymphography. The radiographic findings and effects on clinical management are discussed. The repeat examinations were technically no more difficult to perform than the initial studies. Repeat lymphograms were positive for tumor in 44% of cases. Positive findings were more frequent in patients who received no prior subdiaphragmatic irradiation or in whom the initial study demonstrated lymphomatous infiltration. Interpretative problems include reactive hyperplasia, post-irradiation lymph node alterations, and the lymph nodal distortion occasionally encountered in the treated lymph node which had been involved with tumor.

Adolescent↗

PubMed1975

Bladder cancer: results of radiation therapy in 384 patients.

Between 1957 and 1972, 384 patients with bladder cancers were treated initially with megavoltage radiation therapy. Actuarial five-year survival ranged from 35 to 42% for Stages A and B1 tumors, and was 35, 22 and 7%, respectively, for Stages B2, C and D carcinomas. Approximately 30-40% of deeply invasive tumors confined to the bladder can be controlled with radiation therapy alone, directed solely to the bladder itself.

Aged↗

PubMed1975

Isolation of foamy virus from rhesus, African green and cynomolgus monkey Leukocytes.

Foamy virus (FV) was recovered regularly from the leukocyte of rhesus and cynomolgus monkeys and somewhat less often from African green monkey leukocytes. Virus was found in virtually all organs of experimentally infected rhesus monkeys. No illness or pathologic abnormalities were noted in these animals or in any of the naturally infected animals in spite of the prolonged period of viral persistence in various organs and tissues.

Animals↗

PubMed1974