L-1,4-cyclohexadiene-1-alanine, an antimetabolite of l-phenylalanine produced by a Pseudomonas.
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Biomedical subjects
Publications and source records attributed to N Onishi.
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Effects of locally concentrated loading by repetitive upper limb operations on the musculature were studied in female workers of ages 19--33 rolling photographic film. They repeated rolling and capping of a 35 mm film every 2.5--5 sec during the whole day shift which had a 60 min lunch recess and two 10 min rests. Increase of dull-drowsy symptoms and shoulder complaints was dominant after work, stiff shoulders complaints being divided into 41.6% for prework and 78.7% for postwork. It was characteristic for these workers to have the trapezius muscle showed continuous electromyographic activities in sustaining arms. The average level of the contraction was estimated at about 10--30% of the maximum contraction. Eighty-four per cent of those studied had tenderness at the ascending part of the trapezius, while the same tenderness was found in only 48% of female office workers of the same firm. The operators having low tenderness threshold of 0.6 kg/cm2 or less had stiff shoulders more frequently as well as lower levels of back muscle and upper arm abduction forces than those having no tenderness. It is thus likely that habitual shoulder muscle fatigue is due to repetitive tasks that results in localized tenderness and possibly in occupational hazards.
Physique, muscle strength, and jump-step scores of female industrial workers, ages 17--34, were studied in relation to tenderness of shoulder muscles for five groups, (A) character display operators, (B) fluorescent lamp assemblers, (C) photographic film rolling workers, (D) teachers and nurses of handicapped children, and (E) office workers. No significant differences were found between the five groups in mean body height, body weight, and skinfold thickness, but mean knee extension force of groups A and C and mean back muscle strength of groups A, B, and C was significantly lower than that of group E. Workers of groups C and D with a low tenderness threshold of m. trapezius of 0.6 kg/cm2 or less had stiff shoulders more frequently and lower force levels of knee extension, back muscle, and upper arm abduction than those without tenderness. No similar tendency was found for groups B and E. Further, among workers with objective signs of occupational cervicobrachial disorder, there were few whose knee extension force or jump-step scores were above the averages of normal office workers. Shoulder muscles of such operators were revealed to be continuously contracted during operations. The possible effects of chronic fatigue due to repetitive operations on developing localized tenderness and occupational hazards are discussed.
In mouse bearing progressive cancer a decrease was present in the allogeneic inhibitory activity of T-lymphocytes, which constitutes the core of immunological surveillance system in mammalians. For tests, methylcholanthrene-induced tumor (MC-tumor) was isografted subcutaneously on the back between scapulae of C3H mice, and the lymphocytes were prepared from the regional axillary lymph nodes removed from these mice at 1, 2, 3, or 4 weeks after grafting. These lymph nodes cells were cultured together with 40-fold numbers of allogeneic JTC-11 cells derived from Ehrlich cancer cells in a culture medium containing 2.0% (v/v) PHA for 24 or 48 hours. The proliferation rate of JTC-11 cells (increased numbers) at weekly interval was considered the allogeneic inhibitory activity of lymph node cells. As a result it was demonstrated that in the early stage after tumor transplantation, i.e., in the first or second week, regional lymph node cells showed a strong allogeneic inhibitory activity, as in the case with lymph-node cells from normal mice, but at progressive stage of cancer, i.e., the third or fourth week when tumors were larger, such activity was completely lost. It seems that mice with progressive cancer showed a decrease of allogeneic inhibitory activity, i.e., a disruption of homeostasis was present.
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