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Biomedical subjects

N Okazaki

Publications and source records attributed to N Okazaki.

At least 199 records · Page 11Linked to original sources
PubMed1978

Eicosatrienoic acid omega9 in human hepatoma transplanted into athymic nude mice.

Fatty acid compositions of human hepatoma transplanted successively into athymic nude mice were analysed. Eicosatrienoic acid omega9, which occurred as an unusual positional isomer of eicosatrienoic acid in the original hepatoma tissues, was preserved in these hepatoma tissues over three transplant generations, while the content of linoleic acid in liver was higher in nude mice than in humans. It appears, therefore, that the synthesis of eicosatrienoic acid omega9 is one of the essential metabolic aberrations of human hepatoma, quite independent of nutritional condition.

8,11,14-Eicosatrienoic Acid↗
PubMed1977

Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma: a study of 57 autopsy-proven cases.

The clinical features of 57 autopsied cases of intrahepatic bile duct carcinoma including 28 cases of the peripheral type (cholangiocarcinoma in the narrow sense) and 29 cases of the hilar type are described in comparison with those of hepatocellular carcinoma, with a review of the literature on the clinicopathological aspects of intrahepatic bile duct carcinoma. As compared with hepatocellular carcinoma, the average age of the patients was older; the male predominance was not obvious, chronic parenchymal liver disease was infrequent in the past history, association of primary cirrhosis was seldom, cholestatic features were frequently the early signs and more pronounced during the course, the liver was enlarged to a lesser extent, ascites was less common, signs of portal hypertension were absent or minimal, and extrahepatic metastases were less frequent. In many respects, the hilar type resembled extrahepatic bile duct carcinoma, and the peripheral type was somewhat between it and hepatocellular carcinoma. Although the overall survival was not much different from that for hepatocellular carcinoma, early diagnosis is emphasized; this would make surgical management possible. Differential diagnosis from hepatocellular carcinoma may be possible in the majority with direct cholangiography, liver scan, celiac angiography, determination of alpha-fetoprotein and hepatitis B antigen, and blood chemistry such as SGOT, SLDH, serum bilirubin and alkaline phosphatase. Illustrative cases are given including one patient with a hilar carcinoma who survived for more than 2 years after transhepatic biliary drainage.

Adenoma, Bile Duct↗
PubMed1977

Clinicopathologic features of encapsulated hepatocellular carcinoma: a study of 26 cases.

The clinicopathologic features of 26 cases of hepatocellular carcinoma (HCC) surrounded by a grossly distinct capsule-like fibrous tissue were studied. The frequency of this type was 10.3% among autopsy cases of HCC. The mean age of the patients was 64.1 years, which was significantly older compared with that of 143 cases of nonencapsulated HCC. Hepatitis-B surface antigen in serum was positive in 18.7% of the cases studied, the positivity rate being lower than that of HCC in general. Histologically, the tumor was relatively well differentiated and the capsule was the product of slow expanding growth. Intravenous tumor invasion was less frequent compared with other types of HCC. Clinically, celiac angiography proves to be a most useful diagnostic method; a thick capsule may be demonstrated as a thin radiolucent rim around the mass. The clinical course from the early stage is protracted and, if detected early, this type of HCC may be removed surgically.

Adult↗
PubMed1977

Radiotherapy of hemangioma cavernosum of the liver.

Four patients with massive cavernous hemangioma of the liver were treated with 6 Mev X-ray, and favorable results were obtained in 3. Patient 1 was treated with a total tumor dose of 940 rads without response. The 2nd patient was given a total tumor dose of 1900 rads over 54 days, with a daily dose of 50 to 100 rads. Although the hemangioma regressed after treatment, the response was transient. A total tumor dose of 2940 rads was given over 41 days with a daily dose of 100 to 200 rads as a second course, and the hemangioma regressed with no sign of reenlargement. Patients 3 and 4 were given 150 to 200 rads every other day to a total of about 3000 rads, with a satisfactory response. Follow-up studies showed the latter 3 patients to be well 8, 5, and 4 years after radiotherapy, respectively.

Adult↗
PubMed1975

[Intracranial neurinoma of the jugular foramen-a case report (author's transl)].

This report is a case of intracranial neurinoma of the jugular foramen. A 21-year-old woman was admitted to our hospital with complaints of headache, nausea, tinnitus on the left and deafness on the left. The neurological examination revelaed bilateral choked disc, Bruns Cushing nystagmus, hearing disturbance on the left, slight disturbance of vestibular function on the left, diminished gag reflex on the left, curtain sign on the left, loss of taste on the posterior third of the left side of the tongue, and deviation of the tongue to the left on protrusion, accompanied with atrophy and fasciculation on the left. Skull-XP showed the enlargement of the jugular foramen. Pneumoencephalogram showed the enlargement of the fourth ventricle combined with the superior, posterior displacement of it's floor. We confirmed the diagnosis of the jugular foramen neurinoma on the left. By suboccipital craniectomy a walnutsized tumor was disclosed at the jugular foramen. The tumor was encapsuled with smooth, thick capsule and was colored in dark rouge. This tumor was removed totally and the postoperative course was uneventful. The pathological diagnosis was neurinoma. We consider that this tumor originated in the ninth or tenth cranial nerve.

Adult↗
PubMedDate not supplied

Prognosis of primary hepatocellular carcinoma.

Prognosis of 600 consecutive patients with hepatocellular carcinoma was analyzed in relation to treatment. They were divided into three stages based on four parameters of advanced disease: ascites, tumor greater than 50% of the two-dimensional size of the liver, serum albumin below 3 gm per dl, and serum bilirubin above 3 mg per dl. Stage I had none of these signs; Stage II one or two signs, and Stage III three or all signs. Of 600 patients, 98 had resection, 333 had nonsurgical treatment (158 treated by intraarterial chemotherapy, 94 systemic chemotherapy, 77 transcatheter embolization, and 4 others) and 169 no treatment. The median survival of untreated patients was only 1.6 months from diagnosis, and no untreated Stage III patient lived more than 3 months; there was a median survival of 0.7 month. Surgically treated patients lived significantly longer than nonsurgical patients of comparable stages; median survival was 19.6 months in the former and 2.8 months in the latter. Whereas Stage I patients did fairly well without treatment, chemotherapy significantly prolonged survival of patients of Stages II and III. These results suggest that early diagnosis and hepatic resection improve prognosis in patients with hepatocellular carcinoma in the areas where this cancer frequently emerges unicentrically. In view of the generally poor prognosis, liver transplantation is recommended when resection is not possible or indicated, and before extrahepatic metastasis occurs.

Adolescent↗
PubMedDate not supplied

Experimental otitis media with effusion induced by nonviable Hemophilus influenzae: cytologic and histologic study.

In an earlier study the authors demonstrated that formalin-killed Hemophilus influenzae induces serous-type middle ear effusion in chinchillas and provides an excellent model for the study of human otitis media with effusion. The present study was initiated to evaluate the morphologic and histologic changes that occur in the middle ear after injection of this organism. All of the experimental animals injected with formalin-killed H. influenzae in the present study had straw-colored serous-type effusions within four days after injection. The submucosal thickness, mononuclear cell density, and capillary permeability all increased dramatically in the experimental animals. Marked bleeding, tissue edema, and cellular infiltration in the submucosa were prominent findings after injection of the inactivated bacteria. Half of the experimental animals had histologic evidence of marked proliferation of epithelial cells resembling adhesive otitis media. These findings suggest that nonviable H. influenzae are capable of inducing severe inflammatory changes in the middle ear and may play an important role in the pathogenesis of otitis media with effusion and its sequelae.

Animals↗
PubMedDate not supplied

Cineradiogrphic analysis of eustachian tube function. Experimental study.

In order to determine the effect of muscular contraction upon the opening processes of the eustachian tube, cineradiography of four monkeys' tubes during stimulation of the tensor and levator veli palatini muscles was carried out. Levator stimulation produced no opening of the tube except a dilation of the pharyngeal orifice. On the other hand, tensor stimulation produced a consistent opening of the tube by outward displacement of the tubal wall along its entire cartilaginous part. A marked time lag in the movement of the tube between its proximal (isthmic) and distal (pharyngeal) parts was regarded to be important in the clearance function of the tube.

Animals↗
PubMedDate not supplied

Opening mechanism of the eustachian tube. A clinical and experimental study.

In order to examine the mechanism of tubal opening in detail, the following three experiments were conducted. Experiment 1: The tensor and the levator muscle were selectively stimulated in four monkeys. Tensor stimulation produced constant tubal opening, while levator stimulation had no effect on the opening. This result indicates that the tube opens by the tensor alone. Experiment 2: Cineradiographic studies of the tube during swallowing were conducted in three patients. Motion of the tube, made visible by means of contrast medium, was filmed at a vertical angle. Frame by frame analysis of the film revealed a marked difference between movement of the tube at its pharyngeal orifice and at its cartilaginous part. The result suggested that there are two muscles which dilate two different parts of the tube. Experiment 3: Cineradiography of the tube during selective stimulation of the tensor and the levator muscles was carried out on thre monkeys. Levator stimulation produced dilation of the pharyngeal orifice, but no tubal opening. On the other hand, tensor stimulation produced opening of the tube as a whole, by outward displacement of the lateral wall of the tube. It is concluded that almost the entire cartilaginous part of the eustachian tube opens by contraction of the tensor muscle, while the distal end of the tube increases in diameter by contraction of the levator, but the tube never opens as a whole by its contraction.

Animals↗
PubMedDate not supplied

Relation between nasal and middle ear allergy. Experimental study.

This study was undertaken to clarify the relation between nasal allergy and otitis media with effusion and to observe histologically the allergic changes in the eustachian tube itself in animals. Allergic changes in the eustachian tube and tympanic cavity were clearly observed histologically when the antigen had been introduced into the tympanic cavity of sensitized guinea pigs. On the other hand, administration of the antigen into the nose produced marked allergic changes in the nose and pharynx but no change in the eustachian tube or tympanic cavity. In view of these findings, it is suggested that allergy of the nose bears little direct relation to that of the middle ear and the eustachian tube.

Animals↗