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Biomedical subjects

N Ogino

Publications and source records attributed to N Ogino.

At least 37 records · Page 2Linked to original sources
PubMed1999

Vitreous surgery for traumatic macular holes.

PURPOSE: To review the anatomic and visual outcomes of a series of patients with traumatic macular holes who underwent vitreous surgery without adjunctive therapy. METHODS: We performed a retrospective chart review of 23 patients who underwent vitrectomy, fluid-gas exchange, and sulfur hexafluoride gas tamponade for traumatic macular holes. Anatomic success rate and final visual improvement after the surgery were studied. RESULTS: Medical records of 23 patients (23 eyes) who underwent this procedure were reviewed. Closure of the macular hole was achieved in 16 (70%) eyes with one surgery and in 22 (96%) of the 23 eyes with two surgeries. The mean best-corrected preoperative visual acuity was 20/160, and postoperative visual acuity was 20/60 with a mean (+/- standard deviation) follow-up of 23+/-13 months (range 3-56 months). Fourteen (61 %) of the 23 eyes achieved a best-corrected postoperative visual acuity of 20/60 or better, and 11 (48%) of the 23 eyes achieved 20/40 or better. Twenty (87%) of the 23 eyes achieved at least two lines of visual improvement. CONCLUSIONS: Vitreous surgery without adjunctive therapy for traumatic macular holes can lead to anatomic success and visual acuity improvement in most eyes.

Adolescent↗
PubMed1999

[Multicenter retrospective study of retinal detachment associated with atopic dermatitis].

PURPOSE: Epidemiological and clinical study of retinal detachment associated with atopic dermatitis. METHODS: A multicenter retrospective study. RESULTS: We analyzed 417 eyes of 348 patients operated on during the 5 years from 1989 to 1993 and followed up for more than 6 months by vitreo-retina specialists in 33 hospitals throughout Japan. The number of eyes operated increased yearly from 42 in 1989 to 132 in 1993. These were 2.3% of the average number of the eyes operated on for rhegmatogenous retinal detachment during the same period, but when restricted to the Kanto area or further to Tokyo only, the percentage was as high as 3.8% and 4.7% respectively. Clinical characteristics of retinal detachment previously reported, such as traumatic slapping or rubbing of the lids by patients as the most possible pathogenetic factor, and high incidence of cataract and proliferative vitreoretinopathy, were confirmed. The primary surgical procedure was scleral buckling in 78% of the cases and vitreous surgery in 22%, and initial and final reattachment rates were 75.3% and 92.6%, respectively.

Adolescent↗
PubMed1999

Prognostic Factors in Breast Cancer and their Limitations.

Evaluation of the prognosis of patients with breast cancer is criticai in determining post-surgical adjuvant therapy because of great heterogeneity in response to the therapy, At present, the decision-making for adjuvant therapy largely depends on histologic nodal status, but a significant number of patients without nodal involvement undergo relapse. Although great efforts have been made for more accurate and potent factors, significant indicators have not yet been found. One of the promising candidates, however, is histologic angiogenesis in tumors, which we and others have indicated as an independent prognostic factor in node-negative subset by the multivariate analysis. Here we will evaluate several prognostic factors in clinical use.

Journal Article↗
PubMed1998

Significance of biologic aggressiveness and proliferating activity in papillary thyroid carcinoma.

Papillary thyroid carcinoma is a frequent thyroid cancer. Many factors have been reported to be of prognostic importance, but the significance of biologic factors suggesting aggressiveness and proliferating activity has not been sufficiently documented. Conventional prognostic factors such as age, extrathyroidal invasion, lymph node and distant metastasis, and biologic factors including histologic differentiation, DNA ploidy, S-phase and G2M-phase fractions, and expression of CD44 variant 6 (CD44-v6) obtained from 131 patients who underwent surgery for papillary thyroid carcinoma at Osaka Police Hospital were analyzed retrospectively. Age was closely related to extrathyroidal invasion, G2M-phase fraction, and CD44-v6 expression. Extrathyroidal invasion was independently related to age, gender, and lymph node metastasis. The grade of lymph node metastasis was related to extrathyroidal invasion, gender, distant metastasis, and CD44-v6 expression. Distant metastasis was associated with aneuploid tumors. Cause-specific survival was independently related to biologic factors including extrathyroidal invasion, distant metastasis, DNA ploidy and S-phase fraction. These results suggest that biologic factors indicating aggressiveness and proliferating activity are important for papillary thyroid carcinoma.

Aged↗
PubMed1998

Independent prognostic factors in breast cancer patients.

BACKGROUND: Recently tumor microvessel density has been shown to be a powerful prognostic tool in breast cancer. We attempted to assess its significance as a prognostic factor. METHODS: We analyzed the medical records of 100 patients using univariate and multivariate analyses of nine factors as follows; age, tumor size, nodal status, estrogen receptor, C-erbB2, p53, microvessel density, DNA ploidy pattern, and S-phase fraction. RESULTS: Nodal status and microvessel density were independent prognostic indicators for both survival and relapse-free survival. Microvessel density was independent in the node-negative subgroup for survival, but not independent in the node-positive subgroup, while it was independent in both the node-negative and node-positive subgroups for relapse-free survival. Short-term survival rates in the high and low vessel density subgroups were almost the same, and all patients with early death were node-positive. CONCLUSION: Microvessel density was an important prognostic factor especially in node-negative patients and more significant in long-term survival.

Age Factors↗
PubMed1998

Phacoemulsification, intraocular lens implantation, and trabeculotomy to treat pseudoexfoliation syndrome.

PURPOSES: To determine the long-term risk/benefit ratio of phacoemulsification and intraocular lens (IOL) implantation combined with trabeculotomy to manage eyes with pseudoexfoliation syndrome and co-existing cataract. SETTING: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine; Kurihara Eye Clinic; Departments of Ophthalmology, Tenri Hospital, Kumamoto University, and Matsue Red Hospital; Nagata Eye Clinic, Japan. METHODS: This multicenter retrospective study comprised 49 eyes of 36 patients with pseudoexfoliation syndrome and co-existing cataract who had the combined procedure for uncontrolled intraocular pressure (IOP) (> 21 mm Hg) even on antiglaucoma medication. RESULTS: After a mean follow-up of 20.0 months +/- 13.2 (SD), IOP in all 49 eyes was well controlled (< or = 21 mm Hg). Mean IOP at the final examination was 14.6 +/- 2.6 mm Hg on a mean of 0.9 +/- 0.8 glaucoma medications. Complications included an IOP spike in 11 eyes and fibrin exudation in 1 eye. CONCLUSION: Phacoemulsification and IOL implantation combined with trabeculotomy was an effective treatment for patients with pseudoexfoliation syndrome and cataract.

Aged↗
PubMed1997

A Case of Microangiopathic Hemolytic Anemia Associated with Breast Cancer: Improvement with Chemoendocrine Therapy.

Microangiopathic hemolytic anemia (MAHA) is a term which describes the association of hemolytic anemia with red cell fragmentation caused by microangiopathy mechanically. This paper reports a 45-year-old woman with bone metastases from breast cancer. She developed MAHA and disseminated intravascular coagulation (DIC). Although the prognosis of MAHA associated with malignant tumor has been very poor, she achieved remission of the syndrome after chemoendocrine therapy.

Journal Article↗
PubMed1997

Change in postoperative refractive error when vitrectomy is added to intraocular lens implantation.

PURPOSE: To compare the actual and expected refractive errors after intraocular lens (IOL) implantation alone with those after IOL implantation with simultaneous vitrectomy. SETTING: Shinjo Eye Clinic, Miyazaki, Japan. METHOD: One hundred thirty-six eyes had cataract extraction and implantation of a single-piece IOL using a frown incision, continuous annular anterior capsule tear, phacoemulsification, and intracapsular lens fixation. Thirty-six eyes also had vitrectomy. RESULTS: Mean postoperative refractive error was 0.55 diopter (D) +/- 1.34 (SD) in eyes having no vitrectomy and 0.04 +/- 1.24 D in those having vitrectomy. The difference between groups was statistically significant (P = .047; t-test). CONCLUSION: The refraction after simultaneous IOL implantation and vitrectomy shifted toward myopia by a mean of 0.50 D compared with that after IOL implantation alone.

Adult↗
PubMed1997

[Results of vitrectomy for macular packer after reattachment surgery for rhegmatogenous retinal detachment].

I analyzed the visual results in 184 eyes which had undergone vitrectomy and membrane peeling for macular pucker following treatment for rhegmatogenous retinal detachment. Patient age ranged from 9 to 83 (mean : 55) years, time between reattachment surgery and vitrectomy from 3 to 63 (mean : 15) months, and follow-up from 12 to 96 (mean : 39) months. For the analysis, visual acuity was examined 12 months after the last surgery in 93 pseudophakic eyes and 38 phakic eyes (patients age < 45) and 6 months in 53 phakic eyes (patient age > or = 45). When Y = log 1.5-log (postoperative acuity) and X = log 1.5-log (preoperative acuity), the regression line Y = 0.421 X (R2 = 0.765, p < 0.0001) was obtained. The regression line was Y = 0.395 X (R2 = 0.759, p < 0.0001) for pseudophakic eyes, and Y = 0.488 X (R2 = 0.777, p < 0.0001) for phakic eyes. Thus postoperative visual acuity was higher in pseudophakic eyes than in phakic eyes. When calculated from the pseudophakic line, mean postoperative acuity was 0.2 for preoperative acuity of 0.01, 0.5 for 0.1, and > 1.0 for > 0.5. Postoperative acuity was inversely correlated with the duration between reattachment surgery and vitrectomy (R2 = 0.544, p < 0.0001), and with the patient age (R2 = 0.0046, p = 0.0033). Better postoperative acuity, therefore, was associated with earlier vitrectomy.

Adolescent↗
PubMed1997

[Vitreous surgery for macular hole followed membrane peeling].

We performed vitreous surgery for macular holes following membrane peeling. The cases were five eyes of five females aged 42 to 67 years at the time of membrane peeling, out of 441 eyes of 414 patients who underwent membrane peeling. One eye had secondary epiretinal membrane combined with ocular sarcoidosis, two eyes had idiopathic epiretinal membrane, and two eyes had idiopathic vitreoretinal traction syndrome. The presumed interval from membrane peeling to macular hole formation was 5 to 90 months (average 14 months). For treatment of the macular holes, membrane peeling and SF6 gas tamponade were performed. In four eyes of the five eyes, the macular hole was closed. In the remaining eye, removal of the retinal pigment epithelium from the base of macular hole and application of fibrin glue were used in addition to SF6 gas tamponade, but the macular hole was not closed. The follow-up term was 10-24 months (average 17.6 months). Geometrical mean visual acuity was 0.34 before membrane peeling, 0.94 at maximum after membrane peeling, 0.19 after macular hole formation, 0.51 at maximum after macular hole surgery, and 0.44 at the final visit.

Adult↗
PubMed1997

Trabeculotomy combined with phacoemulsification and implantation of an intraocular lens for the treatment of primary open-angle glaucoma and coexisting cataract.

BACKGROUND AND OBJECTIVE: The authors previously reported the usefulness of trabeculotomy ab externo for the treatment of primary open-angle glaucoma in adult patients. In an attempt to elucidate the long-term risk-to-benefit ratio of this surgical modality in combination with cataract surgery, the authors conducted a retrospective study of the surgical effects and complications of a triple procedure: phacoemulsification, implantation (of an intraocular lens), and trabeculotomy (PIT). PATIENTS AND METHODS: The authors conducted a retrospective study of patients treated with PIT at multiple hospitals. Intraocular pressure (IOP) and visual function data were obtained from patients after PIT as an initial surgical treatment in cases where antiglaucoma medications failed to resolve uncontrolled IOP (higher than 21 mm Hg). Included in this study were 96 eyes of 64 patients with primary open-angle glaucoma and coexisting cataract. The mean follow-up period was 22.6 +/- 14.7 months (range 3-56 months). RESULTS: In 94 (98%) of the 96 eyes, the IOP was well controlled, having achieved a level of 21 mm Hg or lower at the final examinations. The mean preoperative IOP of the 33 eyes that underwent the triple procedure using a single flap method (PIT-I) was 24.3 +/- 3.9 mm Hg, with an average of 2.1 +/- 1.1 medications. At the final examinations, the mean IOP had dropped to 16.0 +/- 1.2 mm Hg, with an average of 1.2 +/- 1.2 medications. The mean preoperative IOP of the 63 eyes that underwent the triple procedure using a double flap method (PIT-II) was 26.2 +/- 6.2 mm Hg, with an average of 1.9 +/- 1.2 medications. At the final examination, the mean IOP for this group was 15.6 +/- 2.9 mm Hg, with an average of 1.0 +/- 0.9 medications. CONCLUSION: The long-term results from this multicenter study showed that the triple procedure, PIT, can be useful and effective as an initial surgical treatment for open-angle glaucoma in glaucoma patients with coexisting cataract.

Adult↗
PubMed1996

Vitrectomy for diffuse macular edema in cases of diabetic retinopathy.

PURPOSE: To ascertain the effects of posterior vitreous detachment for diffuse diabetic macular edema. METHODS: We performed vitrectomy on 58 eyes of 41 consecutive patients with diabetic macular edema without posterior vitreous detachment. Follow-up was done at 12 months postoperatively. RESULTS: In 57 of 58 eyes after vitrectomy and posterior vitreous detachment, macular edema resolved, and diffuse fluorescein leakage disappeared in 35 of 36 eyes examined at the 12th month. Visual improvement was statistically significant (P < .0001, paired t test). CONCLUSION: In eyes with diffuse diabetic macular edema and without posterior vitreous detachment, vitrectomy with posterior vitreous detachment may be effective.

Adult↗
PubMed1996

[Incidence of lack of posterior vitreous detachment in retinal detachment caused by flap tear in the elderly].

I investigated whether posterior vitreous detachment is invariably associated with retinal detachment in the elderly caused by flap retinal tears. Of 97 eyes which underwent vitrectomy, Weiss' ring was not observed in 10 eyes during both the preoperative slit lamp microscope examination and the intraoperative surgical microscope observation. I proved by surgically detaching the posterior vitreous in 5 out of those 10 eyes that the posterior vitreous had not yet become detached before the operation. My results suggest that posterior vitreous detachment may not be associated with 5 to 10% of cases of retinal detachment caused by flap retinal tears.

Aged↗
PubMed1995

Clinical features of retinal detachment in the elderly.

We conducted a retrospective study of 636 eyes (624 patients, aged 65 years or more) to identify the clinical features of nontraumatic retinal detachment in the elderly. The incidence of retinal detachment due to a macular hole in our series (21%) was much higher than those described in previous reports, suggesting a racial difference between Japanese and Caucasian patients. Tractional tear was seen more commonly in patients of less advanced age. In addition, in our series of elderly patients, we demonstrated (1) a preponderance of retinal breaks in the upper temporal quadrant, (2) a high incidence of aphakic retinal detachment, (3) a preponderance of females to be affected and (4) broad detachment of the retina that involved the macula.

Age Distribution↗
PubMed1995

[Induction and properties of nitric oxide synthase in rat retinal pigment epithelial cells in culture].

UNLABELLED: We investigated the production of nitric oxide (NO) and nitric oxide synthase (NOS) by rat retinal pigment epithelial cells (RPE) in culture. METHODS: RPE was isolated from the eyes of 7-10 day-old rats and cultured in Dulbecco's modified Eagle medium with 10% fetal calf serum. NO2- concentration in the culture medium was determined with the Griess reaction. NOS was assayed by measuring 3H citrulline as the reaction product. RT-PCR was performed on the isolated RNA fractions from RPE. RESULTS: Rat RPE produced NOS with the combined stimulation of the bacterial endotoxin and cytokines including interferon gamma. PCR experiments showed that stimulated RPE expressed a gene product corresponding to inducible-type NOS. The enzyme required arginine, NADPH, and tetrahydrobiopterin for the reaction. The specific activity of the crude RPE extract was approximately 270 pmol/min/mg. CONCLUSION: Like bovine RPE, rat RPE produced NOS by the immunological stimulation. Induced NOS and the product NO may play important roles in inflammation of the eye.

Amino Acid Oxidoreductases↗
PubMed1995

[Anterior chamber inflammation after cataract intraocular lens surgery in postvitrectomy eyes].

We determined the anterior chamber inflammation by means of laser flaremetry after cataract intraocular lens surgery for the nuclear cataract that developed after vitrectomy. Cases (38 eyes of 36 patients) were divided into the following four groups according to their pathologies indicating vitrectomy; proliferative diabetic retinopathy (PDR, 14 eyes), idiopathic posterior vitreous membrane syndrome (PVMS, 9 eyes), rhegmatogenous retinal detachment (RRD, 8 eyes), and branch retinal vein occlusion (BRVO, 7 eyes). Mean intervals between the two surgeries were 31, 23, 27 and 18 months, respectively. Phacoemulsification and aspiration through the self-sealing sclerocorneal wound and intraocular lens implantation in the bag were performed. The mean flare count was already high before the cataract surgery in all groups. Postoperative course of mean flare count was an overlap of two waves, one (P1) with a peak on day 1 followed by rapid decrease and the other (P7) with a peak on day 7 followed by slow decrease. Peak values of P1 were higher than the day 1 value after cataract surgery without fundus pathology, and higher in PDR and BRVO groups than in PVMS and RRD groups. P7 was like that observed after vitrectomy and there was close similarity among the groups.

Aged↗
PubMed1995

[Results of macular hole surgery].

Macular hole surgery in 133 eyes of 128 patients resulted in anatomical success (closure and disappearance of the macular hole) in 79% (105 eyes) with the follow-up ranging from 3 to 36 months (8.1 +/- 5.5 months). The anatomical success was correlated with short estimated duration of symptoms, small size of the macular hole and lack of findings suggestive of a long-standing macular hole. Postoperative visual acuity in the anatomically successful cases was correlated with the preoperative visual acuity (positive correlation), the patient age (inverse correlation), and the estimated duration of symptoms (inverse correlation). After macular hole surgery on 63 eyes with 12 months or more in estimated duration of symptoms, 0.3 or more disc diameter in the size, 0.1 or more in preoperative visual acuity, and patient age of more than 70 years, anatomical success was obtained in 95% (60 eyes) and visual acuity of 1.0 or more in 22% (14 eyes), and 0.5 or more in 71% (45 eyes). These conditions, thus, are those indicating good anatomical and functional results.

Adult↗