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Biomedical subjects

N Nohara

Publications and source records attributed to N Nohara.

50 records · Page 3Linked to original sources
PubMed1979

Prolidase deficiency: its dermatological manifestations and some additional biochemical studies.

Prolidase deficiency occurred in a 13-year-old girl. Determinations were made of prolidase and prolinase activities in cultured fibroblasts, and thin layer chromatographic studies of skin prolidase were performed. The patient had chronic, recurrent ulcers on the legs and feet, diffuse telangiectasia, shallow scar-like atrophic lesions on the face and arms, soft and thin abdominal skin, and premature gray hairs. Prolidase in the patient's skin fibroblasts was absent. Greatly reduced prolidase activity was demonstrated in the patient's skin. A review of hitherto reported cases of this disease showed such skin manifestations as (1) skin ulceration or skin fragility with scar formation, (2) purpuric lesions, (3) telangiectasia and/or photosensitivity, and (4) thickening of the skin with lymphedema.

Adolescent↗
PubMed1978

Epidermodysplasia verruciformis: viral particles in early malignant lesions.

Two cases of epidermodysplasia verruciformis were studied histologically and electron microscopically. Four lesions examined were histologically benign, and had viral particles morphologically similar to that of common human warts. Two lesions on the forehead and the face were histologically in the stages of malignant transformation, the intraepidermal epithelioma and the early invasive squamous cell carcinoma. Similar viral particles were also observed in the upper layers of these 2 lesions. These results suggest that at least some of the virus-induced lesions of epidermodysplasia verruciformis actually become malignant.

Adult↗
PubMed1978

[A new method of measuring the system intrinsic variance of scintillation detectors (author's transl)].

A new method is described for the measurement of the system intrinsic variance of scintillation detectors. The system intrinsic variance can be obtained by subtracting the component of photomultiplier variance from the total (observed) variance of detector pulse amplitude; the former component has usually been determined by the use of a light pulser. In the present method, two photomultiplier tubes are optically coupled to a scintillator which is irradiated by a collimated beam of gamma-rays, and the system intrinsic variance is determined from the analysis of mutual correlation of pulse amplitude between the outputs of these two photomultiplier tubes. The method does not need the use of a light pulser, and is able to discriminate the effect of multiple interaction of gamma-rays in the scintillator. A preliminary experiment with a cylindrical NaI(Tl) crystal (4 cmphi X 10 cm) has been performed for a range of gamma-ray energy from 60 keV to 835 keV. The result is well consistent with ones reported by other authors using light pulsers.

Gamma Rays↗
PubMed1977

[Clindamycin-2-phosphate in the field of dermatology (author's transl)].

1. MIC against 20 strains of staphylococcus isolated from skin infections was studied. MIC was less than or equal to 0.05 mug/ml in 11 strains and greater than 100 mug/ml in 9 strains. 2. Clindamycin-2-phosphate was injected intramuscularly to rats at the dosis of 10 mg/kg in solution of 10 mg/ml. The serum and skin levels of this drug were determined at 0.5, 1, 2, 4 and 7 hours. Mean serum levels of 4 rats were 0.893, 0.578, 0.463, 0.268 and 0.167 mug/ml respectively at 0.5, 1, 2, 4 and 7 hours. The corresponding skin levels were 0.500, 0.707, 0.431, 0.313 and 0.269 mug/g. 3. Clindamycin-2-phosphate was used clinically in 7 patients of skin infection with the following result: excellent in 2 cases, fair in 3 cases and poor in 2 cases. Abdominal pain was complained in one case and loose stool in one case.

Adolescent↗