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Biomedical subjects

N Nikolov

Publications and source records attributed to N Nikolov.

At least 19 recordsLinked to original sources
PubMed1991

[Hyperbaric oxygenation as a part of the treatment of chronic ulcerohemorrhagic colitis].

34 patients with chronic ulcerohemorrhagic colitis in exacerbation were treated with hyperbaric oxygenation in addition to the routine therapy. Two chambers model "Dräger" 1000 and 1200 were used. The total course of treatment included 10-12 seances with 60-75 min. exposition each. All patients improved significantly after the first 5-6 seances. The results of the treatment back up the use of hyperbaric oxygenation in the treatment of chronic ulcerohemorrhagic colitis.

Colitis, Ulcerative↗
PubMed1977

[Pathomorphology of infectious bursitis in chicks].

Morphologic studies were carried out on birds aged 17 to 90 days, affected with Gumboro disease and occasionally died from the same disease (infectious bursitis). Established were hemorrhages in the leg and breast musculature, substantial enlargement of the bursa of Fabricius, and lesions in the kidneys. In some cases hemorrhages were also found on the serous membrane of the parenchymal organs. The histologic investigation of the involved parenchymal organs revealed necrobiotic changes (karyopycnosis, karyorrhexis) in the cellular elements, which were evaluated as a possible diagnostic symptom. Discussed is the problem of the dynamics of the morphologic changes observed in the bursa of Fabricius in view of their differential-diagnostic value.

Animals↗
PubMed1977

[Study of gastric secretion in white rats with a chronic gastric fistula on endotoxin exposure].

The author carried out a study on the stomach secretion in white rats endotoxin shock, induced by venous adminsitration of endotoxin, obtained from Escherichia coli. Stomach fistula was made on the rats in advance and the stomach juice was collected under the condition of chronic experiment. The amount of stomach juice was estimated in mililiter per hour as well as the content of free hydrochloric acid, total aidity and electrophoresis of proteolytic enzymes. There was a statistically significnat lowering of the amount of stomach juice, diminuation of free hydrochloric acid and of total acidity acidity as well as diminution of complete disappearence of its proteolytic activity in the rats after endotoxin action.

Animals↗
PubMed1975

Hemoglobin-Strumica or alpha 2 112(G19) His replaced by Arg beta 2. (With an addendum: hemoglobin-J-Paris-I, alpha 2 12(A10) Ala replaced by Asp beta 2, in the same population).

Hemoglobin-Strumica has been observed in five members of a Macedonian family. Histidyl residue in position 112 of the alpha chain of this variant is replaced by an arginyl residue. Two other variants (hemoglobin-Dakar and hemoglobin-Hopkins-2) in which this histidyl residue has been replaced by a glutaminyl and by an aspartyl residue, respectively, have been described (Rosa et al. (1968) 12 thCongr. Int. Soc. Haematol. New York, abstract, p. 73 and Charache, S. and Osterag, W. (1970) Bloodt 36, 852). The hemoglobin-Strumica heterozygotes have minimal hematological changes although this may not necessarily be associated with the hemoglobinopathy. Subjects heterozygous for hemoglobin-Dakar have a mild hemolytic anemia and hemoglobin-Hopkins-2 heterozygotes exhibit minimal hematological changes.

Adolescent↗
PubMed1975

Delta Beta-Thalassaemia in two yugoslavian families.

Members of two Yugoslavian families were found to have delta-beta-thalassaemia. Interaction of beta-thalassaemia with delta-beta-thalassaemia occured in two young children producing a clinical condition which is somewhat less severe than that of homozygous beta-thalassaemia. Results from biosynthetic analyses indicate that the degree of globin chain imbalance in double heterozygotes for beta- and delta-beta-thalassaemia is similar to that in homozygous beta-thalassaemia. Fetal haemoglobin of all heterozygotes contained G-gamma and A-gamma chains in an average ratio of about 2:3 whereas that in the two double heterozygotes had G-gamma and A-gamma chains in a ratio of 3:2.

Adolescent↗
PubMed1975

[Dipeptidase activity in the small intestine of patients with chronic nonspecific enteritis].

Dipeptidase activity in homogenate from small intestinal mucosa is determined according to the method of Josefsson (1965) in 45 patients with chronic non-specific enteritis. The majority of the enzymes are of the endopeptidase group, degrading the dipeptides of the neural aminoacids; glycyl-alanine, alanyl-l-valine, glycyl-l-isoleucine, analyl-glycine, leucyl-l-leucine, alanyl-l-leucine, alanyl-l-proline, glycyl-l-glutamic acid; only one enzyme-glycyl-l-leucine dipeptidase belongs to the enzymes of the brush-like zone of the enterocyte. The glycyl-l-alanine dipeptidase enzyme activity was established to be decreased with 49,2 per cent, glycyl-l-leucine--with 33,2 per cent, glycyl-l-valine with 19,6 per cent, glycyl-l-isoleucine--with 61 per cent, etc. The diminished enzyme activity corresponds, in the majority of the cases, to the severity of the disease and to the degree of the histological changes. It does not reach the decreased degree, found in the patients with coliac sprue. In a series of cases the enzymatic activity does not correspond to the morphological changes: "normal activity" and decreased peptidase activity were found in six cases and in two cases--"partial mucosal atrophy" and normal or elevated peptidase activity. Very likely, the pointed out enzymes, are of a substantial importance for the pathogenetic digestive and resorbtive disturbances in chronic non-specific enteritis, especially protein disturbances.

Adult↗
PubMed1975

[Diagnosis and treatment of gastrocolic fistulae and erroneous anastomoses following gastric resection].

Results are reported of a clinical examination and surgical treatment of seven cases with gastro-jejunocolic fistulas and five cases with gastroileoanastomosis. The clinical picture, irrigography, steatorrhea, hypoproteinemia, etc. are stressed upon as important for the diagnosis. The operation result depended on the degree of the resorbtive disturbances, on successful reanimation and frequent postoperative complications. Postoperative lethality is five out of 12 cases.

Adult↗