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N Moriyama

Publications and source records attributed to N Moriyama.

At least 145 records · Page 8Linked to original sources
PubMed1994

[Psychophysical scaling of translucent sensory measurement of tooth crowns].

The purpose of this study is to investigate the translucent sensory measurement as a basic study for developing the translucent sensory scale (Haze Guide) of tooth crowns. Seven subjects with normal visual sensation were examined to search for the translucent sensory interval of uncertainty using methods of limits, and 3 panels were selected from this result and prepared for further experiments. Fact-findings of the translucent senses were performed on these 3 panels using the magnitude estimation method and the absolute judgement method. With these methods we were able to construct the translucent sensory measurement and to establish the ranges of Haze scores and magnitude of each step and a permitted limit of each Haze tab, which should be possessed with the tooth crown translucent sensory scale. The results were as follows: 1. The translucent senses were well adapted to the Stevens power law of modality characteristic exponent. The exponent was 1.74. 2. Standard light translucent sensory guide for tooth crowns were in the range between 25. 2% and 91.9% at Haze values. Eighteen steps were arranged within this range, and when the Haze difference was taken larger at lower Haze values and the difference was taken smaller accordingly at higher values, the visual sensation came to achieve an equally appearing interval of translucency.

Adult↗
PubMed1994

[Treatment of advanced prostatic cancer--chronological change between 1975 and 1991].

A chronological analysis of the clinical features and treatments of advanced prostatic cancer, stages C and D, was performed in 154 cases treated from 1976 through 1991. These cases were divided into two chronological groups: 61 cases treated between 1976 and 1983, and 93 cases between 1984 and 1991. Concerning demographic features and diagnosis, the number of patients with lymph node metastasis was higher in the latter group. There was also increase in cases who were urologically asymptomatic and detected by checkup digital rectal examination or by the elevation of serum prostatic tumor markers. Histopathological differentiation was consistent between the two groups; more than 70% of cancers were moderately and poorly differentiated adenocarcinoma. As for the treatment, total prostatectomy was performed in eight cases in the latter against none in the earlier, but hormonal therapy remained the main treatment throughout the periods: 74.2% in the earlier and 70.7% in the latter. However the methods of the therapy have clearly changed; estrogens and castration were used less often in the latter period, while LH-RH analogues and antiandrogens replaced them although the therapy was equally effective in 82.3% of the cases in the earlier and in 90.4% in the later period and five-year survival rate and the progression-free survival rate at three years showed no significant difference between the two periods. These results showed 1) refined quality of diagnosis 2) a change in mode of hormonal therapy and 3) no detectable improvement of survival in these 16 years. Development of more effective therapies would be warranted for a better survival.

Aged↗
PubMed1994

[Two-color flow cytometric analysis of lymphocytic subsets in renal cell carcinoma].

The subsets of tumor infiltrating lymphocytes (TILs) in 17 patients with renal cell carcinoma were studied by two-color flow cytometry and immunohistochemistry. In grade 1 tumors, CD4-positive cells were significantly increased compared to grade 2 and 3 tumors (35 +/- 7% vs 25 +/- 10%) (p < 0.05). In 10 of 14 patients, CD8-positive cells were predominant over CD4-positive cells, resulting in less than one in CD4/CD8-ratio. Regarding CD4 cells in all 17 cases, the helper T-cells (CD4-positive and CD45RA-negative) were statistically predominant over the inducer T-cells (CD4-positive and CD45RA-positive) (p < 0.01). When CD8 cells were investigated in 16 out of the 17 cases, the cytotoxic T-cells (CD8-positive and CD11b-negative) were found also significantly predominant over the suppressor T-cells (CD8-positive and CD11b-positive) (p < 0.01). Immunohistochemically, the infiltrating pattern of TILs in the 17 patients was classified into cluster (N = 4), separate (N = 6), and mixed types (N = 7). The tumor in the cluster and mixed type had a tendency to be dominant in low grade tumors, and had the prominent CD8-positive cells (more than 90% were cytotoxic T-cells) over CD4-positive cells. However, no statistical significance was noted in this finding. The advanced tumor tended to show the single type of TIL infiltration. These results suggest that cytotoxic T-cells consisted of most of TILs in cluster and mixed types play an immunoreactive role against renal cell carcinoma.

Adult↗
PubMed1994

Detection of nodular lesions in the lung using helical computed tomography: comparison of fast couch speed technique with conventional computed tomography.

The present study assessed the ability of helical CT performed at fast couch speeds (20 mm or 25 mm/sec), sufficient to cover the entire lung field during a single breath hold, compared with conventional CT for detecting pulmonary nodules in patients with metastatic lung disease. The subjects were seven consecutive patients with metastatic lung tumors in whom 152 lesions were detected by conventional CT. The average diameter of the nodules was 8.3 (range 2-23 mm). To scan the entire lung, we first employed conventional CT (10-mm slice thickness, 10 mm couchtop slide). We then used helical CT with couchtop speeds of 20 and 25 mm/sec, permitting easy scanning of the entire lung field during a single breath hold (images of reconstruction intervals; 25, 20, 12.5 and 10 mm). We assessed each image to compare detection capabilities in the lung. The detection capabilities for each reconstruction interval were 78, 83, 91 and 97%, respectively. The detection of nodules was superior for 12.5 and 10 mm images than for 25 and 20 mm images (P < 0.01). In 25 and 20 mm images, the detection capability was significantly lower in the apical area than in the middle area (P < 0.01). For nodules 5 mm in diameter, 10 mm images permitted complete detection. Helical CT fast couch speeds (20 or 25 mm/sec), which allow imaging of the entire lung during a single breath hold, may be useful in detecting metastatic pulmonary nodules, and helical CT is expected to be a useful method for lung screening.

Aged↗
PubMed1994

Accuracy of computed tomography in determining pancreatic cancer tumor size.

We compared tumor sizes determined by computed tomography (CT) with those of the resected specimens in 26 patients with pancreatic cancer in order to clarify whether or not the size of a pancreatic tumor can be accurately determined by CT. From the precontrast, postcontrast and arterial dominant phases of dynamic CT, the arterial dominant phase was found to yield the highest correlation between CT measured tumor size and that of the resected specimens (P < 0.01). The correlation coefficient was, however, not high (r = 0.67). CT alone may therefore be insufficient to determine tumor size in pancreatic cancer accurately.

Adenocarcinoma↗
PubMed1994

Radiological study of idiopathic Budd-Chiari syndrome complicated by hepatocellular carcinoma. A report of four cases.

During an 11-yr period (1979-1989), we have experienced five patients with idiopathic Budd-Chiari syndrome (BCS), four (80%) of whom had associated hepatocellular carcinoma (HCC). In contrast, the incidence of BCS complicated by HCC was 0.7% of a total of 556 patients who underwent surgery for HCC or were autopsied. Hepatitis B virus-related antigen or antibody was positive in one patient each. Four of our five patients were asymptomatic and were initially diagnosed by ultrasonography (n = 3) or computed tomography (n = 1). The hepatic parenchyma histopathological findings were cirrhosis and fibrosis in one each. Infection of hepatitis B virus rather than BCS was speculated as a causative factor for HCC in two patients. Membranous obstruction with spotty calcification, intrahepatic bizarre communicating vessels, and the dilated anterior longitudinal veins in spinal canal were recognized in three patients. Three patients had two HCCs which were similar in size and arose from the right and left hepatic lobe, separately, suggesting multicentricity of HCC. Both percutaneous transluminal angioplasty with Gruntzig balloon catheters for the obstruction of the inferior vena cava and hepatic arterial embolization for HCC(s) were performed in three patients. These patients survived 29.3 months on average after the diagnosis of BCS complicated by HCC(s). The opened IVC was confirmed to be patent on an average of 26.3 months after the first angioplasty.

Adult↗
PubMed1993

[Evaluation of helical scan CT in the detection of lung nodules of pulmonary metastasis].

The purpose of this study was to evaluate the diagnostic capability of helical scan CT (HS-CT). We investigated the ability of HS-CT to detect lesions by scanning 129 small nodular lesions in the lung field in six cases of pulmonary metastasis. HS-CT was then employed to scan the same regions at table slide speeds of 20 mm/sec and 25 mm/sec. The acquired images were recorded on film and a video tape recorder (VTR), using axial multiplanar reconstruction. We then compared the various images to evaluate the effectiveness of conventional CT (slice thickness: 10 mm, table slide pitch: 10 mm) and HS-CT in visualizing the lesions. HS-CT images acquired at 20 mm/sec and at 25 mm/sec were equally effective in visualizing the lesions. Diagnostic capability was significantly lower in the apical area than in the middle and subdiaphragmatic areas. VTR images were better than film images in terms of diagnostic capability. The disadvantage of VTR images was that VTR processing required much time and labor, and thus is not practical at present. In conclusion, HS-CT is useful in detecting small nodular lesions in the lung field. However, the scanning conditions of HS-CT and interpretation of images, especially in the apical area, require further improvement.

Humans↗
PubMed1993

Response of early-stage hepatocellular carcinoma and borderline lesions to therapeutic arterial embolization.

OBJECTIVE: In Japan, borderline lesions and early-stage hepatocellular carcinoma (HCC) are now histopathologically divided into two subgroups; one includes adenomatous hyperplasia and atypical adenomatous hyperplasia, and the other includes early HCC and early advanced HCC. In order to evaluate the efficacy of transcatheter arterial embolization for treating such lesions, histopathologic studies were done after embolization and resection in 27 patients. MATERIALS AND METHODS: The lesions consisted of two adenomatous hyperplasias, one atypical adenomatous hyperplasia, 22 early HCCs, and 13 early advanced HCCs. All patients had chronic liver diseases in nontumorous parenchyma in addition to HCC. For transcatheter arterial embolization, one of the following embolizing materials was used: iodized oil (Lipiodol) alone (n = 4), an emulsion of doxorubicin in Lipiodol (n = 8), and the same emulsion followed by gelatin sponge particles (n = 15). RESULTS: The frequencies of tumor stain on the angiogram and retention of Lipiodol within the tumor were 84% and 94% in overt HCC, 23% and 69% in early advanced HCC, and 9% and 9% in early HCC, respectively. The average size of overt HCC was significantly (p < .01) larger than that of early advanced HCC and early HCC. The amount of necrosis induced by embolization relative to the size of the mass was 56% on average in overt HCCs, 14% in early advanced HCCs, and 0% in early HCCs, atypical adenomatous hyperplasias, and adenomatous hyperplasias. Significant differences (p < .01) in mean necrosis rate were seen between overt HCCs and early advanced HCCs, between early advanced HCCs and early HCCs, and between overt HCCs and early HCCs. The frequency of Lipiodol retention correlated with mean necrosis rate for tumor. With reference to therapeutic techniques, only for the overt HCCs was a significant difference (p < .01) in the mean necrosis rate found between the group that received the emulsion of doxorubicin in Lipiodol and the group that received the emulsion and then particles of gelatin. CONCLUSION: This study suggests that transcatheter arterial embolization has limited efficacy for treating early-stage HCC and borderline lesions compared with its efficacy for treating overt HCC.

Aged↗
PubMed1993

[Clinical observations of advanced renal cell carcinomas--the chronological change between 1975 and 1991].

An analysis has been undertaken to determine chronological changes that have occurred in the clinical features and treatments of advanced renal cell carcinomas. To accomplish this, 96 renal cell carcinoma cases, handled by the authors' department and at the branch hospital, were divided into two groups: 48 patients treated between 1975 and 1983 (group 1) and 48 patients treated between 1984 and 1991 (group 2). Between the two groups, no differences were seen in the sex ratio, the mean age, and the ratio of those who were found to be advanced cases at the time of diagnosis and those whose cancers had advanced after undergoing a nephrectomy. Concerning treatment, interferon (IFN) and UFT were more frequently used in treating group 2 than group 1, and chemotherapy, radiotherapy, and endocrine therapy less frequently used. No differences were seen in the prognosis between the two groups; however, in those who had advanced after nephrectomy, group 2 cases survived for a significantly longer period than did group 1 cases. Patients who survived for 5 years or longer accounted for two cases in group 1 and 5 cases in group 2 and combination therapies involving surgery, IFN, UFT, or similar medications were used for their treatments. These results suggest that adjuvant therapies, such as surgery, IFN, and UFT, have possibly contributed to prolonging survival, especially for cases that advanced after nephrectomy.

Carcinoma, Renal Cell↗
PubMed1993

Combined hepatocellular carcinoma and cholangiocarcinoma: clinical features and computed tomographic findings.

Clinicoradiological features were studied in 20 patients with 22 mass lesions of combined hepatocellular carcinoma and cholangiocarcinomas and findings of computed tomography in 12 of these patients with 14 hepatocellular carcinoma-cholangiocarcinomas. Five of these patients also had single overt hepatocellular carcinomas. The incidence of hepatocellular carcinoma-cholangiocarcinoma was 3.3% among the patients with primary liver cancer treated in our hospital. HBsAg was present in 25%, and increased levels of serum alpha-fetoprotein (> 200 ng/ml) and carcinoembryonic antigen (> 5 ng/ml) were found in 25% and in 47%, respectively. Associated cirrhosis was present in 60%. Analysis of 14 hepatocellular carcinoma-cholangiocarcinomas in 12 patients in whom the enhancement pattern on dynamic computed tomography and pathological findings could be studied and compared suggested three tumor types. Nine lesions (type A) were demonstrated only as areas with high-density peripheries in the early phase of enhancement that evolved into a pattern of peripheral low density and central high density in the late phase. Four masses (type B) were shown as hyperdense tumors (early phase) that changed to low density in the late phase. One mass (type C) was seen as a low-density lesion that did not change. Histopathologically, type A comprised hepatocellular carcinoma-predominant components in the peripheral area, cholangiocarcinoma-predominant components with abundant fibrous stroma in the central area and a tissue transitional between the two in the midzone. By contrast, two of four type B masses comprised hepatocellular carcinoma with scattered cholangiocarcinoma components throughout the tumor.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

A century of modern dental education in Japan: the history of the Tokyo Dental College.

At the end of the revolution against the Tokugawa Shogun in 1868, the new Meiji government introduce Western medicine and science into Japan. Dental education, however, was neglected by the new regime. Dr. Kisai Takayama, a Samurai warrior turned dentist, realized this and established the first dental school in Japan in 1890. Meeting a definite need, the school expanded several times and introduced into the country standards which raised Japanese dental education to the level of that in the Western world. In 1990, the hundredth anniversary celebration of the school was held, following the completion of the school's magnificent new campus in 1981 and a new headquarters building in 1990.

Education, Dental↗
PubMed1993

Hepatocellular carcinoma with portal tumor thrombus: analysis of factors determining prognosis.

For 104 consecutive patients with hepatocellular carcinoma (HCC) with portal tumor thrombus (PTT) seen in the past nine years, prognostic factors were analyzed retrospectively using Cox's multivariate analysis. There was a significant difference in survival rate with hepatic functional reserve (Child classification, P = 0.005), type of treatment (surgical vs non-surgical treatment, P = 0.009) and PTT grade (P = 0.04). The survival rates for patients with Child's A (n 49) or Child's B (n 55) were 60.8 vs 20.0% at one year, 41.6 vs 9.1% at two years and 35.4 vs 5.5% at three years. The survival rates of patients with surgical (n 32) and non-surgical (n 72) therapy were 71.7 vs 25.0% at one year, 58.5 vs 9.4% at two years and 53.6 vs 4.7% at three years. Among patients with PTT grades in the third or lower order branch (Vp1, n 29), the second order branch (Vp2, n 32) and the first or portal vein trunk (Vp3, n 43), the one-year, two-year and three-year survival rates were 61.6, 43.8 and 20.9%; 47.1, 27.5 and 6.2% and 42.8, 27.5 and 0%, respectively. When analysis was focused on 32 patients with Child's A and PTT (Vp1 plus Vp2) with respect to treatment, the survival rates in the surgical (n 22) and nonsurgical (n 10) groups were 86.1 vs 70.0% at one year, 71.5 vs 30.0% at two years and 64.3 vs 20.0% at three years (P < 0.05), respectively. In HCC patients with PTT, surgery seems to be indicated where hepatic function is well preserved and the PTT is localized in a peripheral portal branch.

Adult↗
PubMed1993

Helical computed tomography scanning of the thorax and abdomen.

We applied helical CT to examinations of the abdomen and thorax. Scanning was performed continuously while the couchtop of the CT scanner was shifted at a constant speed. The entire lung field could be scanned during a single holding of the breath when the couchtop speed was 20 mm/s. Tumors as small as 3 mm were detected. The diagnostic detectability and accuracy of helical CT were far superior to those of conventional chest radiography. During abdominal examination, the target organ could be scanned at any specified phase (preferably arterial) during the injection of contrast medium. We detected very small hepatic tumors which could not be detected by conventional CT. Helical CT produced continuous data, which was reconstructed to display three-dimensional images. Helical CT could be used in mass screening for the detection of early lung cancer and in computer-aided diagnosis.

Abdominal Neoplasms↗
PubMed1992

Intrapulmonary sublesions detected before surgery in patients with lung cancer.

BACKGROUND: The treatment of patients with multiple intrapulmonary lesions remains controversial. METHODS: Fifty-three patients with lung cancer, in whom preoperative evaluation disclosed intrapulmonary nodules distinct from the main tumor, were analyzed retrospectively to establish the optimal treatment in such cases. RESULTS: These sublesions proved to be intrapulmonary metastases (PM) in 16 cases (30%), multiple primary lung cancers in 7 cases (13%), and various nonmalignant lesions in the others. The survival of the 53 patients, and of patients with clinical Stage I/II disease in particular, compared favorably with that of all patients with resected lung cancer. Those with multiple sublesions had a poorer prognosis, irrespective of their nature. Although patients with PM as sublesions often had clinically advanced cancer, metastatic foci, per se, did not influence the survival data as calculated by a multivariate analysis. CONCLUSIONS: The authors conclude that the existence of a solitary intrapulmonary sublesion should not preclude surgical treatment, unless surgery is contraindicated because of other clinical and radiologic findings.

Humans↗
PubMed1992

A clinical and radiologic study of primary liver cancer associated with extrahepatic primary cancer.

In a consecutive series of 393 patients with excised and pathologically proven primary liver cancer (PLC)--including 374 hepatocellular carcinomas (HCC), nine cholangiocellular carcinomas (CCC), and ten mixed type of HCC and CCC--33 patients (8.4%) had one or two other malignancies in the extrahepatic organ(s). Of these, 29 had double cancers and four, triple cancers. This was synchronous in 11 patients, metachronous in 20 (including 18 with double cancers and two with triple cancers) and synchronous and metachronous in two with triple cancers. Metachronous cancer was found in 21 patients 1 year before hepatectomy for PLC and in three patients, 1 year after hepatectomy. The median age of PLC patients with multiple primary cancer (MPC) was 63.6 +/- 6.9 years; this was significantly greater than that of PLC patients without MPC (P less than 0.01). The associated cancer was gastric cancer in 11 patients (29.7%), colorectal cancer in six, pharyngeal cancer in four, and other cancers in ten different organs in 16. Thirteen of 22 patients had a history of blood transfusion. The incidence of liver cirrhosis in PLC associated with MPC (57.6%) was significantly lower than that without MPC (82.8%, P less than 0.01). The differential diagnosis of PLC from liver metastasis was possible retrospectively in 78.6% using sonograms, 79.3% using computed tomograms, and 91.3% using angiograms. The survival rates of patients with PLC with (n = 33) and without (n = 299) MPC who had undergone hepatectomy were 97.0% and 85.4% at 1 year, 55.5% and 59.5% at 3 years, and 40.5% and 40.1% at 5 years, respectively. There was no significant difference between the survival rates of those who underwent operations for PLC and extrahepatic primary cancer(s) synchronously and metachronously.

Adenoma, Bile Duct↗
PubMed1992

Postresection recurrence of hepatocellular carcinoma treated by arterial embolization: analysis of prognostic factors.

Of 270 consecutive patients with hepatocellular carcinoma who underwent surgery, 50 who had recurrence and were subsequently treated with transcatheter arterial embolization were analyzed. The longest interval between surgery and recurrence in the 50 patients who underwent transcatheter arterial embolization was 7 yr. Recurrence was initially found in the remnant liver in all patients but one; extrahepatic metastases were detected in 13 patients (26%) during follow-up. A "multiple" type was the most common (64%) hepatic recurrence pattern on angiography, followed by the "solitary" (16%) and "tumor thrombus" (12%) patterns. Hepatic recurrence was most frequently found in the ipsilateral lobe (48%) relative to the site of the primary hepatocellular carcinoma. Multivariate analysis of the factors affecting survival after transcatheter arterial embolization indicated that recurrence pattern (p = 0.025) and distant metastases (p = 0.011) were significant. Of 13 patients with distant metastases, 11 had the "multiple" pattern of hepatic recurrence. Survival rates for all 50 patients after initial surgery and after transcatheter arterial embolization were 90% and 64%, respectively, at 1 yr; 52% and 24%, respectively, at 3 yr; and 27% and 5%, respectively, at 5 yr. On analysis of survival rates after transcatheter arterial embolization in 37 patients with recurrence only in the liver and of the response of recurrent hepatocellular carcinoma to transcatheter arterial embolization, a significant difference was noted between those with "partial response" and "progressive disease" (p less than 0.05) and between those with "no change" and "progressive disease" (p less than 0.05).

Adult↗