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Biomedical subjects

N Minami

Publications and source records attributed to N Minami.

At least 253 records · Page 14Linked to original sources
PubMed1980

Influences of the submaxillary gland of male mice on the immune response to sheep red blood cells.

Removal of the submaxillary gland (SMG) from male but not female mice caused a suppressed immune response to sheep red blood cells. Administration of a SMG saline extract from male mice to SMG-ectomized males restored the suppressed response to control levels. This suggests that the male mouse SMG contains a factor(s), possibly of an endocrine nature, capable of influencing cells involved in an immune response.

Animals↗
PubMed1980

Male mouse submaxillary gland secretes highly toxic proteins.

Submaxillary gland saliva induced by phenylephrine from male mice was highly toxic to guinea-pigs, rats and hamsters, whereas the toxicity was relatively low to mice. One of the toxic components in the saliva was isolated as a kallikrein-like enzyme.

Animals↗
PubMed1980

Reduction of N-acetyl-beta-glucosaminidase activity in the submaxillary glands of streptozotocin diabetic mice.

Streptozotocin diabetes strongly reduced the N-acetyl-beta-glucosaminidase activity in the submaxillary glands of mice. A reciprocal change was observed between the enzyme activity and blood sugar in diabetes. Insulin treatment of th diabetic mice returned the reduced activity to the normal level. Isoelectric focusing analysis showed that the submaxillary gland enzyme was composed of two isozymes having isoelectric points (pI) of 4.8 and 8.8. Only the pI 8.8 isozyme was affected by the diabetes.

Acetylglucosaminidase↗
PubMed1980

Developmental change and hormonal control of beta-glucosidase activity in rat kidney.

beta-Glucosidase activity in rat kidney increased progressively with age, from 4 weeks after birth up to 52 weeks. A marked sexual difference in enzyme activity was found in the adult kidney. The activity in adult males was 1.4--2.1 times higher than in adult females. Castration of males decreased the beta-glucosidase activity to an about normal female level and the decreased activity returned to a normal male level following injeciton of testosterone. Ovariectomy did not affect enzyme activity. Adrenalectomy decreased enzyme activity to about 50% of the normal level in both males and females and the decreased activity returned to a normal level following injection of hydrocortisone.

Adrenalectomy↗
PubMed1980

Effect of autonomic agents on the secretion of N-acetyl-beta-glucosaminidase of mouse submaxillary gland.

The secretion of N-acetyl-beta-glucosaminidase of mouse submaxillary gland into saliva was stimulated by norepinephrine and phenylephrine but not by pilocarpine and isoproterenol. The stimulative effects of the alpha-adrenergic agents were inhibited by alpha-blockers, phentolamine, and phenoxybenzamine. These results suggest that the secretion of the enzyme is regulated through alpha-adrenergic receptors.

Acetylglucosaminidase↗
PubMed1980

[Treatment of infection in the patients wih hematopoietic malignancy with ceftezole (Falomesin) (author's transl)].

Ceftezole (CTZ) was administered to 20 patients with hematopoietic malignancy complicated with infections. These patients consisted of 7 cases of AML, 2 ALL, 2 AMMoL, 1 APL, 1 blast crisis of CML, 2 HD, and 5 NHL. In 13 cases, sites of infection were determined and causative organisms were identified. In other 7 cases, sites of infection or causative organisms were unknown. In the former 13 cases, pneumonia was demonstrated in 6 patients, tonsillitis in 4 patients, pyelonephritis in 2 patients and sepsis in 1 patient. Klebsiella was separated from 5 patients as the causative organisms, E. coli from 2 patients, E. coli and Pseudomonas aeruginosa from 1 patient, Pseudomonas cepacia from 1 patient, Streptococcus viridans from 2 patients, Proteus from 1 patient and Torulopsis from 1 patient. Gram-negative rods were separated from 10 of the 13 cases (77%) as the causative organisms. CTZ was administered intravenously in dose from 4 g to 16 g per day combined with other antibiotics (AMK, GM, DKB, TOB, SBPC, CBPC, LC, ST). The response rate in 12 cases of acute leukemia and in 7 cases of malignant lymphoma was 58% and 43%, respectively. Infections occurred in 4 patients with less than 100 neutrophil per mm3 did never favorably responded even with CTZ.

Adolescent↗
PubMed1979

Androgenic regulation of N-acetyl beta-glucosaminidase activity in the submandibular glands of mice.

N-Acetyl beta-glucosaminidase [beta-2-acetamido-2-deoxy-D-glucoside acetylamido-deoxyglucohydrolase; EC 3.2.1.30] in the submandibular gland of mice was found to be androgen-dependent; the specific activities in males, females, and castrated males were 0.25, 0.11, and 0.11 unit/mg protein, respectively. The activities in females and castrated males were increased to the level of normal male mice by testosterone injection. Injections of progesterone and 17 beta-estradiol hardly affected the activity in males. In both males and females, the enzyme activity was detected in the convoluted tubular cells, not in acinous cells. The results of isoelectric focusing have shown that one enzyme having an isoelectric point of 9.0 is present in the glands of both sexes, indicating that the enzyme remains after castration and that the increases caused by testosterone represent the same molecular species. In addition, it was shown that the saliva from both sexes contained significant activity of N-acetyl beta-glucosaminidase, which also changed depending on the androgenic state of the animals. Most of the salivary activity was shown to originate from the submandibular gland, since the extirpation of this gland resulted in a significant decrease of the salivary activity.

Acetylglucosaminidase↗
PubMed1979

Regulation of delayed-hypersensitivity response by the submandibular gland of male mice.

This study was performed to determine whether the removal of submandibular gland (SG) of mice influences the delayed-hypersensitivity (DH) response. The removal of the SG increased the weights of thymus and spleen and enhanced DH response, only in males and not in females. The injection of crude extract of male mouse SG returned the enhanced DH response of SG-ectomized males to the normal level whereas the injections of crude extracts of female or castrated male mouse SG was not affected. These results suggested that SG of male mice contains an endocrine factor(s) to regulate DH response.

Animals↗