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Biomedical subjects

N Mihalache

Publications and source records attributed to N Mihalache.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Microalbuminuria following exercise, an early sign of diabetic nephropathy.

Microalbuminuria after physical exercise is characteristic for the preclinical stage of diabetic nephropathy, permitting an early diagnosis of this severe complication of diabetes mellitus. In 24 patients with type I diabetes, 11 women and 13 men free of clinical and biological signs of renal damage, the presence of microalbuminuria has been investigated by radial immunodiffusion in the urines collected between 3 and 7 hrs in the morning, as well as after a 20-min rest following a moderate exercise of 75 watts during 20 min at the ergometric bicycle. The patients were distributed into four groups, according to the age of disease, and microalbuminuria was expressed in micrograms/min. Compared with the mean values recorded in normal subjects by the same method (6.8 micrograms/min), the level of microalbuminuria has been significantly higher in the cases evaluating since more than two years, in keeping with the time elapsed after onset, and particularly following exercise. No relationship could be established between the quality of metabolic control of diabetes and the levels of microalbuminuria after exercise.

Adolescent↗
PubMedDate not supplied

Study of some lymphocyte metabolic parameters in diabetes mellitus.

Cytochemical study of peripheral lymphocytes in 78 diabetic patients and 22 controls included the determination of glycogen (with calculation of the "glycogen score"), lipids and nucleolar RNA (with calculation of the so-called "lymphocyte nucleologram"). All three metabolic components showed marked differences between the diabetes and the controls. Further analysis in terms of sex, patient's age, duration of disease, basic treatment and main complications of diabetes, also showed certain variations of the above parameters but of lesser amplitude. Metabolic alterations of lymphocytes in diabetes mellitus reflect the pathogenic particularities of the disease, and might probably be used as a basis for further practical purposes.

Cell Nucleolus↗
PubMedDate not supplied

The dynamic of impaired glucose tolerance in women with fetal gigantism.

In a group of 51 women who had given birth to giant children, the glucose tolerance test (GTT) was performed at entry in the study and after intervals of 6 to 12 years. The results of the first determination, estimated according to the WHO's criteria (1980), have revealed an impaired glucose tolerance (IGT) in 7 cases (14%); the second determination showed IGT in 10 cases (20%) and diabetes mellitus in 2 (4%). Insulinemia assays, concomitant with the second performance of GTT, showed the highest values in the diabetic subjects, moderate values in those with IGT, and low values in those with normal glucose tolerance. The presence of obesity in some cases could not be considered as fully responsible for the glucose tolerance impairment in the women with fetal gigantism. The dynamics of glucose tolerance disorders showed variations in time, i.e. the initial pathologic changes were no more recorded on the second testing in the same subjects, while women with normal initial GTT showed high insulinemia or IGT on the second determination.

Adult↗
PubMedDate not supplied

Plasma phosphorus and magnesium values during treatment of severe diabetic ketoacidosis.

Plasma phosphorus and magnesium were determined in 76 diabetics, admitted with severe ketoacidosis (pH less than or equal to 7.20, total CO2 less than or equal to 10 mEq/l) before and 24 hours after beginning the treatment, which did not include supplementary phosphorus or magnesium. Phosphorus presented initially high values (1.76 + 0.69 mEq/l) which fell substantially 24 hours after beginning the treatment (0.87 +/- 0.26 mEq/l); magnesium values, initially low (0.76 +/- 0.19 mEq/l), fell still further within 24 hours of treatment (0.64 - 0.16 mEq/l). For phosphorus (and to a lesser extent for magnesium) calculation of the regression line indicated a direct positive relationship with both hydrogen ion concentrations (r = 0.67) and blood glucose (r = 0.73), the differences being statistically significant. The more rapid the decrease in glycemia and correction of acidemia and the greater the amount of glucose administered in the course of treatment, the more marked was the fall of plasma phosphorus and magnesium values.

Adolescent↗
PubMedDate not supplied

Metabolic "responders" and "non-responders" to muscular exercise in diabetes.

The metabolic effects of muscular exercise (bicycle ergometer, 75 watts, 15 min) were studied in 16 healthy controls and 49 diabetics distributed into three groups. The first two groups included insulin-dependent diabetics three hours after administration of insulin (group A, 24 cases) or 12--18 hours after the last insulin dose (group B, 18 cases). Group C included 7 non insulin-dependent diabetics. According to the glycemia response, the patients were listed as: high responders (greater than 20% below the initial values), low responders (10-20% fall) and non-responders (increase or less than 10% decrease). The data obtained show that, in most cases, in the presence of insulin, exercise has a hypoglycemic effect and, in its absence, a hyperglycemic one. To a lesser extent, the fall in glycemia may be attributed to an apparently insulin-independent mechanism. Exercise can only be indicated (in high-responders) or contraindicated (in non-responders) after a routine tolerance test.

Adolescent↗
PubMedDate not supplied

The behaviour of some biologic parameters in obese patients after short-term exercise under restrictive diets.

Seven obese female patients with a mean age of 40 have received for 3-4 days a diet of 1000 cal followed by a diet of 300 cal/day. At the end of each period of diet, the patients performed an exercise of 75 watts for 15 min on the ergometric bicycle. Some biologic parameters determined before, as well as 15 min and 60 min after exercise did not show important differences in terms of the diet applied. Glycemia was constantly low, while glucagon, lactate and free fatty acids (FFA) values rose, particularly within the 15 min following exercise. After the same interval, insulinemia was unchanged or even increased. These results support the opinion that, even under restrictive diets, the reaction of obese patients to a short-term exercise is similar to that of normal weight subjects, their sources of energy being the same. The behaviour of insulinemia, which did not change or even increased, while in normal weight subjects it decreases on exercise, might be due to a lesser epinephrine activity in obese patients and/or a lesser FFA release from the adipose tissue.

Adult↗