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Biomedical subjects

N Masaki

Publications and source records attributed to N Masaki.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Subcutaneous fibrosis induced by external irradiation of carcinoma of the uterine cervix].

Two-hundreds and seventy-six patients who were treated with external irradiation alone or combined with intracavitary irradiation and were alive 2-18 years were examined concerning to late complications in the lower abdominal wall. Moderate or severe subcutaneous fibrosis occurred in 14% of the patients. They were not observed below subcutaneous dose of 44 Gy. However, they were noted in 22% with dose of 45-54 Gy and in 100% with dose over 55 Gy. The dose of 50% probability of fibrosis was expected around 53 Gy and 80% of complications were appeared within 3 years after irradiation.

Abdominal Muscles↗
PubMed1987

[Results of radiation therapy of extranodal non-Hodgkin's lymphoma of the head and neck--a study of the Japan Lymphoma Radiation Therapy Study Group].

During the years 1972-81, 168 patients with extranodal Non-Hodgkin's lymphoma localized in the head and neck were treated with radiation. Five-year survival rates were 62% in stage I, 56% in stage II, and 91% in diffuse well-differentiated lymphocytic, 77% in diffuse mixed, 52% in diffuse poorly-differentiated lymphocytic and diffuse histiocytic each. Marginal relapse was rare after radiation therapy, but relapses were not infrequently noticed in distant extranodal sites. Bone and/or soft tissue relapses were frequently noticed in patients with lesions initially located in the nasal cavity, paranasal sinus and oral cavity.

Adolescent↗
PubMed1987

[Thyroid dysfunction following external irradiation of the neck].

Thyroid function after radiation therapy to the neck was studied in 120 patients, 110 of whom were suffered from malignant lymphomas. No patients had clinical symptoms from thyroid dysfunction, but 9 patients were given thyroid hormone after examination of thyroid function test. TSH elevation rate for 95 patients irradiated to the hole neck by dosage was 0%, 24%, 47% and 47%, for less than 30 Gy, 30-39 Gy, 40-49 Gy and 50 Gy or more, respectively. The effects of lymphangiography and systemic combination chemotherapy on the thyroid function were also discussed.

Adolescent↗
PubMed1987

[Late radiation effect on the eye].

In order to analyze the chronic radiation injury on the eye, 264 cases with carcinoma of the paranasal sinuses were accumulated from the four large hospitals. 50% appearance dose of the chronic radiation injury, chiefly the radiation cataract, in 3, 5, 7 and 10 years after radiotherapy was 51.6 Gy, 28.3 Gy, 23.9 Gy and 21.6 Gy, respectively.

Dose-Response Relationship, Radiation↗
PubMed1987

[Analysis of tolerable radiation dose on the oral mucosa and mandibular bone--external beam and/or brachytherapy].

Cooperative study from six institutes was made for the late radiation damage of oral mucosa and mandibular bone. Analysis was made for the selected patients with oropharyngeal cancer for external beam alone and with tongue cancer for interstitial implant. All of them were followed at least two years without recurrence having no secondary treatment after initial radiotherapy. As for external beam alone, frequency of the mucosal ulcer was not increased with high dose level, but tolerance dose for the oral mucosa was limited from associated mandibular damage. Late damages were not likely after brachytherapy alone.

Brachytherapy↗
PubMed1987

[Bone damage of mandibles after radiotherapy of carcinoma of the tongue].

At Osaka University Hospital, the 5-year survival rate for carcinoma of the tongue, treated by radiotherapy, is almost 60% and in early cases, around 80%. However, with this improvement in the survival rate, an increase in the incidence of various complications (xerostomia, soft tissue ulcer, bone damage, etc.) has been observed. Because of these circumstances, a radiographic analysis on the bone damage of the mandibles after radiotherapy was made. Only those patients whose progress had been followed for more than one year and whose disease was well controlled were selected for this study. Early radiographic signs of bone damages showed an enlargement of the periodontal space and a loss of lamina dura. From the results of the study it has been found that bone damage is less common in patients treated by interstitial radiotherapy alone. Bone damage seems to develop more frequently in patients who receive about 30 Gy by external radiotherapy, followed by more than 2,000 mgh. Ra. eq. of interstitial radiotherapy.

Aged↗
PubMed1987

Multiple primary malignancies in patients with head and neck cancer.

During the 15 years from 1967 to 1981, 3,162 patients with carcinoma of the head and neck were treated with radiation therapy. Among them, 262 patients (8.3%) developed two or more independent malignancies. There were 80 patients with prior cancer. The overall incidence of second malignancies in patients who had radiation therapy was 5.8%. The incidences were 8.9, 7.7, 5.2 and 1.7% of index cancer in the larynx, pharynx, oral cavity and paranasal sinus, respectively. Second primaries were observed in the head and neck (36%), digestive tract (35%), lung (19%) and the remaining 10% in other bodily sites. Of the 1,486 patients who survived for five years or more after radiation therapy, only 10 (0.7%) developed second malignancies within the previous radiation field.

Adolescent↗
PubMed1987

[Low-grade non-Hodgkin's lymphomas--report of the Japanese Lymphoma Radiation Therapy Group (JLRTG)].

The clinical features of 102 patients with low grade non-Hodgkin's lymphomas treated from 1972 to 1981 among the hospitals belonging to the JLRTG were retrospectively reviewed. According to the Rappaport classification, there were 29 cases of NPDL, 26 of NM and 47 of DWDL. The survival rate and relapse-free survival rate for all patients at 10 years were 49% and 41%, respectively. No obvious difference in survival rate was seen by histologic type, but patients with DWDL had a better relapse-free survival rate than those with NM (P less than 0.01). This study also suggested that patients with stages I and II low grade lymphomas might be treated by irradiation alone, if they are staged properly.

Adult↗
PubMed1986

[Treatment results of carcinoma of the lower gum with radiation therapy combined with bleomycin].

One hundred six patients with carcinoma of the lower gum were treated with radiation (30 Gy/three weeks) and bleomycin (90 mg/three weeks), and the results were analyzed. Of these, 66 (62%) patients experienced a complete clinical response (CR), and 47 were observed with no further treatment. The local control rate of these patients was 31/47 (66%) at two years. Higher CR and local control rates of 43/61 (70%) and 24/33 (73%), respectively, were obtained in patients with small (T1, T2) tumors than in those with large (T3, T4) tumors [23/45 (51%) and 7/14 (50%), respectively].

Adult↗
PubMed1986

[The role of bleomycin combination in radiation therapy of squamous cell carcinoma of the oral cavity].

In an effort to improve tumor control by radiation therapy, a treatment regimen consisting of concurrent combination of bleomycin (90 mg/3 weeks) and radiation (30 Gy/3 weeks) was applied. Between 1972 and 1981, 287 patients with squamous cell carcinoma in the oral cavity were subjected to this bleomycin-radiation combination regimen. All except 4 patients experienced marked response after treatment using the bleomycin-radiation combination alone. One hundred thirty-four patients (47%) obtained CR and 149 (53%) PR. Higher CR rates were obtained in patients with carcinoma of the lower gum (62%), of the upper gum (68%), and of the cheek mucosa (43%), compared to patients with carcinoma of the floor of the mouth (21%), and of the tongue (15%). In each of the tumor sites, small lesions (T1, T2) obtained higher CR rates, compared with large lesions (T3, T4). Of the 134 patients who experienced CR, 83 were observed without any further treatment after bleomycin-radiation combination alone. Local recurrence-free rates of these patients were 72% for T1, T2 lesions and 48% for T3, T4 lesions. Local control rates were increased to 85% and 78%, respectively, with successful salvage treatment involving surgery or interstitial radiotherapy for post-irradiation failures.

Bleomycin↗
PubMed1986

[The role of radiotherapy in the treatment of non-Hodgkin's lymphoma of the thyroid].

Retrospective analysis was made of 30 cases of non-Hodgkin's lymphoma treated from 1967 through 1983 at the Department of Radiology, Osaka University Hospital, according to the Ann Arbor staging classification modified by us. Overall five-year survival and five-year relapse-free survival were 62% and 60%, respectively, with one out of 9 cases treated since 1979 being lost due to relapse. In cases with disease localized in the thyroid and neck nodes (Stage IIE-a, by modified classification), five-year survival of 74% was obtained, whereas in those with the lesion extending to the mediastinum (IIE-b) or axillae (IIE-c), the survival pattern was similar to that with Stage II and IV. Complete local control was obtained in all cases by radiotherapy.

Adult↗
PubMed1986

[The role of computed tomography in the follow-up of cancers of the head and neck].

The role of computed tomography (CT) in the follow-up after treatment for cancers of the head and neck was evaluated, using patients treated at the Department of Radiology, Osaka University Hospital. CT is one of the useful tools for follow-up after radiotherapy in selected cases of cancers in the oro-, hypopharyngeal and laryngeal regions. The extent of local recurrence cannot easily be estimated by CT after reconstructive surgery. It is recommended that CT be undertaken routinely to check for recurrence during the stable period after surgery. Eight cases are presented.

Aged↗