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Biomedical subjects

N M Hadler

Publications and source records attributed to N M Hadler.

112 records · Page 7Linked to original sources
PubMedDate not supplied

A pathogenetic model for erosive synovitis: lessons from animal arthritides.

Adjuvant arthritis, streptococcal cell wall-induced arthritis, and Erysipelothrix insidiosa arthritis are laboratory models of relapsing, erosive synovitis. A review of the experimental literature suggests that their pathogenesis is similar. The persistence in macrophages in the pannus of nonbiodegradable microbial cell wall components containing the peptidoglycan moeity is the central event. Based on this experimental literature, a model for the pathogenesis of these arthritides is developed. This model is testable and relevant to erosive synovitis in man.

Animals↗
PubMedDate not supplied

Polyclonal hyperviscosity syndrome.

The clinical course of two patients who presented with polyclonal hyperviscosity syndrome is described. Polymerizing IgG rheumatoid factors were isolated from the serum of both patients. The presence of these polymers with their extraordinary rheologic properties was the principal determinant of the abnormal rheological properties of the plasma. Neither patient had a discrete rheumatic disease. In both, a lymphoproliferative syndrome was present with features suggestive of the "pseudolymphoma" of Sjögren's syndrome.

Blood Viscosity↗
PubMedDate not supplied

Rheumatoid nodulosis. Sporadic and familial diseases.

Two patients are described with longstanding, multiple, subcutaneous nodules with the histopathological features of rheumatoid nodules. Neither patient had any clinical evidence of rheumatic disease. One patient had a family history of smiliar nodules transmitted as an autosomal dominant trait. Leukocyte function studies failed to reveal any defect to account for the nodule formation.

Female↗