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Biomedical subjects

N Kopp

Publications and source records attributed to N Kopp.

At least 127 records · Page 7Linked to original sources
PubMed1977

[Hemispheric asymmetries of the human brain].

The authors studied 181 brains, 103 of which were dissected. They observed a "T1-T2 bridge" over the first temporal and second temporal gyri more often on the left side than on the right. This asymmetry was more frequent in males than in females. The maximal width of the superior aspect of the second temporal gyrus was greater on the right side in the majority of cases. By contrast, the fusiform gyrus was found wider on the left side in most subjects. The length of the precuneus was greater on the right. The greater size of the left planum temporale could be correlated with the sectional area of the anterior white commissure. The same correlation was found between the length of the precuneus and the area of the latter commissure. Anatomical asymmetries of the two cerebral hemispheres in man seem to be numerous. The interpretation of these asymmetries is difficult; some are likely to be related to functional asymmetries. In the future, the study of morphological asymmetries in routine neuropathology, in patients who have been submitted to detailed neuropsychological examination, would appear to be desirable.

Cerebral Cortex↗
PubMed1977

[Alpers' infantile cerebral poliodystrophy. A case with abnormal hepatic pyruvate carboxylase].

The authors describe an anatomical familial case of progressive infantile cerebral poliodystrophy (Alpers disease), in which the study of enzyme kinetics of hepatic pyruvate carboxylase revealed an abnormal graph reflecting a loss of activity of the enzyme with low concentrations of substrate, This is a new feature in the literature on Alpers disease, and possibly indicates one of the pathogenic mechanisms responsible in this disorder which remains mysterious, although its pathology has been clearly described.

Ataxia↗
PubMed1976

[Proliferation of the transverse tubular system during a tardive and familial myopathy].

The authors report a case of non-progressive, late-onset, recessive, sex-linked myopathy. Electron microscopy reveals a striking proliferation of the T system. This proliferation might be interpreted as indicating an abortive attempt of muscle to regenerate, which could explain the clinical course. Some basic ultrastructural aspects concerning the T system are reported. The signification of the findings of numerous "zebra bodies" is discussed.

Adult↗
PubMed1976

[Asymmetry of the cerebral hemispheres in man: a bridge binding the 1st and the 2d temporal gyri, superior face of the 2d temporal gyrus, and fusiform gyrus].

The autors study 76 human brains, 36 of which are dissected. They observe a "T1 T2 bridge" over the first temporal and second temporal gyri more often on the left side than on the right. They find the maximal width of the superior face of the second temporal gyrus predominant on the right side in 70% of cases, on the left side in 15% and equivalent on both sides in 15%. The fusiform gyrus is found wider on the left side in 53% of cases, on the right in 22% and equivalent on both sides in 25%.

Dissection↗
PubMed1975

[Neuropathology of trichopoliodystrophy (Menkes' disease). Anatomoclinical observation].

The authors describe an anatomo-clinical case of trichopoliodystrophy in many ways similar to cases already published. The original features of the case are as follows: the ultrastructure of the duodenal mucosa is normal; the endoplasmatic reticulum of the putaminal neurons contains many-layered lamellar structures probably composed of protein; type II fibres predominate in the striated skeletal muscle suggesting abnormal neuromuscular maturation.

Blindness↗
PubMedDate not supplied

[Extemporaneous histopathological examination in neurosurgery. Report on 500 cases].

The authors review 500 extemporaneous histopathological examinations done in a neurosurgical unit over a 16-month period. The following four questions are asked by the neurosurgeon: is there a tumor? is it a primary or secondary one? what variety is it? what is its degree of malignancy? The percentage of errors was respectively: 2 per cent, 2.2 per cent, 8.8 per cent and 7.4 per cent, or roughly, a percentage two times lower than in a series from the same laboratory done before the use of the low-temperature microtome. It especially seems that the tumoral variety is often determined accurately in meningiomas, neurinomas, medulloblastomas and craniopharyngiomas. In gliomas the variety is often more difficult to accurately affirm, and especially the "grade" of malignancy. The authors analyse the problems raised by the different types of tumors.

Brain Neoplasms↗
PubMedDate not supplied

Polyglucosan bodies and temporal lobe epilepsy: an incidental finding or more?

This study reports on histological findings in the temporal lobe of a 36-year-old woman who underwent a right temporal lobectomy for pharmaco-resistant complex partial seizures. Since surgery, the patient has remained seizure-free. The patient had an established diagnosis of right temporal lobe epilepsy, based on video EEG recordings of seizures, MRI hippocampal atrophy, focal interictal hypometabolism on fluoro-desoxyglucose, hypofixation of Cl1-flumazenil in PET studies, and ictal intracerebral recordings. Biopsies were studied under light- and electron microscopy. Histology showed diffuse distribution of a large number of polyglucosan bodies (PBs) in the whole right temporal lobe white matter. PBs were mostly confined to the perivascular areas and in subpial zones rarely and were observed in the most superficial cortical layers. There was some neuronal loss, especially in opercular zone T , but no other histological lesion was found. Ultrastructurally, PBs were made of filamentous and amorphous material, and were found both in intra-astrocytic processes and in axons. The presence of numerous PBs in the temporal lobe of patients with refractory temporal lobe epilepsy has been reported in 3 patients in the literature. It raises the questions whether this histological abnormality could be related to the epileptogenic process as a cause or as a consequence.

Adult↗