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Biomedical subjects

N Komatsu

Publications and source records attributed to N Komatsu.

At least 235 records · Page 13Linked to original sources
PubMed1977

[Effect of schizophyllan on delayed hypersensitivity in the mouse (author's transl)].

The delayed cutaneous hypersensitivity test with picryl chloride was used to demonstrate the effect of sonicated schizophyllan (SPG-S) on cellular immunity in mice. The increase of ear thickness in mice treated with SPG-S (0.5 approximately 10.0 mg/kg) 24 hours before the sensitization with picryl chloride proved to be significantly larger than that in untreated mice on testing with picryl chloride at 7 days following sensitization. Mice were intramuscularly injected with SPG-S (5.0 mg/kg) on -48, -24, 0, +24 or +48 hours of sensitization. Remarkable stimulating effect of SPG-S on the delayed hypersensitivity was recognized in all groups of mice, being somewhat lower in the group treated with SPG-S 48 hours after the sensitization. Stimulating effects of lipopolysaccharide, concanavalin A, pokeweed mitogen and SPG-S on the delayed hypersensitivity were compared. The effect of SPG-S was similar to that of concanavalin A, a nonspecific stimulant for T cells.

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PubMed1975

[Influence of schizophyllan, streptomycin and rifampicin on histopathological changes in mice infected with tubercle bacilli (author's transl)].

Experimental tuberculosis in mice infected with streptomycin-resistant Mycobacterium tuberculosis SCHACHT strain was treated with streptomycin or rifampicin alone and in combination with schizophyllan. The histopathogical tests of various organs of the treated mice were carried out. 1) In the group of mice treated with streptomycin alone, the moderate focal proliferation of RE cells were seen at the beginning of infection. However, durable activation of RE cells and the prolongation of life-span could not be recognized as compared with control animals. 2) The treatment with streptomycin-schizophyllan combination appeared to be somewhat more effective than schizophyllan alone, the phagocytic capacity being more strongly stimulated. 3) In the group treated with rifampicin alone, the therapeutic effect could be exhibited by the direct antibacterial action of rifampicin, but the activation of RE cells was slight. When rifampicin was discontinued, the growth of tubercle bacilli was rapidly resumed, and the durable therapeutic effect seemed not to be expected. Degeneration of hepatic cells tended to develop. 4) In the group treated with rifampicin-schizophyllan combination, the antibacterial effect of rifampicin appeared to be potentiated by the strong activation of RE cells by schizophyllan, showing the durable therapeutic effects.

Animals↗