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Biomedical subjects

N Javadpour

Publications and source records attributed to N Javadpour.

At least 145 records · Page 8Linked to original sources
PubMed1978

Postoperative management of patients with pheochromocytoma.

The optimal preoperative and postoperative management of patients with pheochromocytoma demands a multidisciplinary approach. We report on 5 recent patients to illustrate the large volumes of fluid needed in the early postoperative period. This large fluid requirement is owing to a combination of a change in vascular compliance after excision of a pheochromocytoma, the residual effects of specific preoperative medications (phenoxybenzamine and alpha-methyl-p-tyrosine) and the loss of fluid into the retroperitoneal compartment (third space) produced by extensive dissection. It takes 3 half-lives (36 hours) to dissipate the effects of phenoxybenzamine and alpha-methyl-p-tyrosine, which corresponds to the time in which these patients require large volumes of intravenous fluids.

Adrenal Gland Neoplasms↗
PubMed1978

The cell surface antigen A, B or O(H) as an indicator of malignant potential in stage A bladder carcinoma: preliminary report.

The presence or absence of cell surface antigens (A,B and H) on the cell surface of bladder tumors has been studied. The major blood group antigens A, B or O(H) are present on normal bladder epithelium but are not present on some low grade and low stage papillary transitional cell carcinomas of the bladder. We have demonstrated that of 5 stage A bladder tumors that have not recurred in at least 5 years 3 retained the cell surface antigens, while tumors that have recurred locally, invaded or metastasized had lost these cell surface antigens on the original stage A tumor.

ABO Blood-Group System↗
PubMed1978

The role of the radioimmunoassay of serum alpha-fetoprotein and human chorionic gonadotropin in the intensive chemotherapy and surgery of metastatic testicular tumors.

Quantitative measurement of serum alpha-fetoprotein and human chorionic gonadotropin by double antibody radioimmunoassays reflects the efficacy of surgical, radiation and/or chemotherapeutic regimens in patients with bulky disseminated testicular tumors. When these therapies are effective they produce an immediate decrease in serum levels of these markers that reflects the decrease in tumor size and could be as rapid as the catabolic decay rate for alpha-fetoprotein or human chorionic gonadotropin. The alpha subunit of human chorionic gonadotropin has a short half-life (20 minutes) and has been used for the first time to localize a recurrent metastatic testicular tumor. Cellular localization of these markers by immunochemical techniques has helped us to understand the natural history of this cancer and the cell types responsible for production of the markers.

Adult↗
PubMed1978

Adrenal cortical tumors with low attenuation coefficients: a pitfall in computed tomography diagnosis.

Four cases of adrenal tumors with unusually low attenuation coefficients are reported. The tumors presented with values ranging from 8 to 17 EMI units (EU: 500 scale) instead of the expected 30 to 40 EU range of the remainder of our adrenal tumors. Two of these patients had primary aldosteronism and two had Cushing's syndrome. An unusually high lipid content may be responsible for the lucent appearance.

Adrenal Cortex Neoplasms↗
PubMed1978

Transcatheter brush biopsy of intravenous tumor thrombi.

Transcatheter brush biopsy of intraluminal filling defects demonstrated during venography was performed in 6 patients with abdominal neoplasms. Tissue specimens consistent with either known or subsequently proved tumor were obtained from 4 patients. Biopsy was negative in the other 2 patients, who lacked surgical confirmation of the intraluminal mass. This technique is useful in establishing histological proof of neoplasm and in determining the extent of known tumor.

Abdominal Neoplasms↗
PubMed1978

Biodegradable ureteral grafts in dogs.

In six dogs, a segment of the right ureter was replaced by a tubular segment of poly [L(-) lactic acid], a new absorbable biomaterial, with the hope that the foreign body would be absorbed or dissolved after a new mucosally lined channel had formed. The dogs were followed with excretory urograms, blood urea nitrogens, and serum creatinines. Postoperatively, four of the six dogs had deteriorating or total loss of function of the right kidney by 8 months attributable to obstruction of the ureter by disintegrating implant.

Animals↗
PubMed1978

Immunochemical determination of human chorionic gonadotropin and alpha-fetoprotein in sera and tumors of patients with testicular cancer.

In several prospective studies during the past 5 years, we evaluated 400 patients with nonseminomatous and 60 with seminomatous testicular tumors with the use of serum and cellular AFP and HCG at the NCI. Ninety percent of the patients with nonseminomatous testicular tumors had elevated levels of either HCG and/or AFP that have been useful in detection, staging, prognosis, and monitoring the efficacy of the therapeutic modalities. Although 5% of the patients with pure seminoma had an elevated level of serum HCG, one must search for elements of nonseminomatous testicular tumor in these patients by serial section of the seminoma specimen. Elevated serum AFP in patients with designations of seminoma indicates the presence of an element of embryonal carcinoma and/or teratoma. We have localized these markers in various tumor cells by using the technique of indirect immunoperoxidase. The HCG is localized in syncytiotrophoblastic component of choriocarcinoma and syncytiotrophoblastic giant cells occasionally found in association with embryonal carcinoma, teratoma, and seminoma. The AFP is localized in embryonal and endodermal sinus tumor.

Adult↗
PubMed1977

Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using and indirect immunoperoxidase technique.

An immunohistologic study of 21 patients with germ cell tumors of the testis with measured serum levels of chorionic gonadotropin (HCG) and alpha-feto protein (AFP) was undertaken to correlate the various types of neoplasms with the presence of these tumor markers in the tissue and serum. AFP was demonstrated in mononuclear embryonal cells within embryonal carcinoma and endodermal sinus tumor. HCG was identified within syncytiotrophoblastic giant cells, frequently in association with embryonal carcinoma, and rarely with endodermal sinus tumor and seminoma, as well as in the syncytiotropho-blastic component of choriocarcinoma. Eighteen of the 21 patients (86%) had elevated tumor markers in their serum; serum HCG alone was elevated in five (24%), AFP alone in five (24%) and both were elevated in eight (38%). There was tissue localization of HCG in 12 of the 13 patients (92%) with elevated serum HCG while AFP was identified in the tumor in eight of the 13 patients (53%) with elevated serum AFP levels. Based on these findings, a tentative immunohistologic classification of germ cell tumors utilizing AFP and HCG is proposed. Thus, embryonal carcinoma, adult type, is frequently associated with both AFP and HCG, endodermal sinus tumor with AFP and choriocarcinoma with HCG, whereas pure seminoma and teratoma are unlikely to be associated with either marker.

Chorionic Gonadotropin↗
PubMed1977

Jejunal loop interposition in patients with ileal conduit failure after pelvic exenteration.

Although the ileal conduit is currently the most widely used method for urinary diversion in patients undergoing pelvic exenteration, reports continue to accumulate indicating the frequency of long-term complications. Four patients with failure of ileal urinary diversion after pelvic exenteration for invasive pelvic malignancy are presented. All four patients had either multiple pelvic surgical procedures and/or pelvic radiation. Interposition of jejunum between the proximal ureters or renal pelvises and skin was performed with satisfactory results in all four. In patients with pelvic exenteration and failure of ileal urinary diversion this technic offers the following advantages over the conventional revision of the ileal conduit: (1) eliminates use of radiated small intestine which is subject to fistula formation and/or obstruction; (2) avoids the settling of the urinary conduit in the devitalized pelvic space with potential adhesions, fistula formation, or obstruction; (3) ensures proximal jejunal loop is away from area of potential tumor recurrence and field or previous or future radiotherapy; (4) eliminates the extensive dissection of the adherent ileal conduit and subsequent risk of avascular necrosis; and (5) bypasses the radiated fibrotic distal ureters.

Adenocarcinoma↗
PubMed1977

Technique for extracorporeal resection of dissecting renal arterial aneurysm with renal autotransplantation.

A progressively enlarging dissecting aneurysm of the right renal artery secondary to fibromuscular dysplasia presents a difficult surgical problem. We present a technique of extracorporeal approach for correction of such aneurysm in a patient with dissecting aneurysm and hypertension. This technique utilizes a Teflon patch graft to facilitate the arterial anastomosis of the renal autotransplantation.

Adult↗