Search PubMed⌕ Search

Biomedical subjects

N Javadpour

Publications and source records attributed to N Javadpour.

At least 37 records · Page 2Linked to original sources
PubMed1988

A phase I-II study of high-dose recombinant human interleukin-2 in disseminated renal-cell carcinoma.

Natural interleukin-2 is a lymphokine with an immunoregulatory function. The recombinant interleukin-2 (rIL-2) is cloned from a human lymphoblastoid T-cell line for this trial. The gene is expressed in E-coli, allowing production of large quantities of rIL-2. This study is an open label phase I-II trial designed to evaluate the toxicity and efficacy of a rIL-2 in disseminated renal cell carcinoma. After surgical resection of the primary tumor, 3 X 10(6) units/m2 day rIL-2 is administered by 2-hr IV infusions daily for 5 days every other week for a total of eight cycles. At the conclusion of eight cycles of therapy, the patients were re-evaluated for response. Patients with complete and partial responses were eligible to receive an additional eight cycles every other week. Patients demonstrating progressive disease during this study were withdrawn. The toxicities of the high-dose rIL-2 included transient hypotension, pyrexia, malaise, and skin rashes. The transient hypotension responded to fluid replacement, and the other toxicities also responded to symptomatic treatment. The early results in ten patients indicate two partial and one complete response. We have concluded that administration of high-dose interleukin-2 has acceptable toxicities with encouraging response and deserves a phase III study.

Adult↗
PubMed1987

Computed tomography of Kock and modified Kock continent ileal reservoir.

Kock or modified (Javadpour) ureteroiliostomy was performed in 5 patients following cystectomy for bladder carcinoma or exstrophy. Computed tomography was utilized to demonstrate alterations in pelvic anatomy after construction of the ileal reservoirs. Detailed evaluation of the inlet and outlet antireflux arms of the continent reservoir was possible. Appreciation of the expected alterations in pelvic anatomy accompanying the Kock or modified Kock procedure will be necessary to detect postoperative complications and to achieve early recognition of recurrent carcinoma. Potential advantages of the modified Kock ileal reservoir, as developed by Javadpour, are presented.

Aged↗
PubMed1987

Magnetic resonance imaging (MRI) in staging of the prostatic cancer.

In a prospective study, the role of MRI in the staging of prostatic cancer has been assessed in 32 patients. The results of MRI has been compared with those conventional staging modalities for prostatic cancer including pelvic CT, cystoscopy, bimanual examination and biopsy of the prostate. The final clinical and/or pathologic staging was obtained. The results of CT were compared with those of MRI in a blind fashion. In 22 of Stage A and B neither MRI nor CT were able to define the extension of the disease. In no cases were results of CT superior to the MRI. However, in 10 cases, the seminal vesicles were involved and these cases were interpreted as stage C. In exploration 2 out of 10 cases had metastases shown by MRI. It is concluded that MRI is more sensitive in revealing the detail of the seminal vesicles thereby detecting the bulk of the tumor and the extension of cancer into the soft tissue of the lymphadenopathy of this organ. The role of MRI in the detection of and the utilization of paramagnetic media remains to be studied.

Humans↗
PubMed1986

Predictors of recurrent clinical stage I nonseminomatous testicular cancer. A prospective clinicopathologic study.

A prospective clinicopathologic study of 60 patients with clinical Stage I nonseminomatous testicular cancer (NSTC) has been reported. Of 60 patients with clinical Stage I NSTC who underwent retroperitoneal lymphadenectomy (RPLA), 6 proved to be Stage II, a staging error of 10 per cent. In 4 patients of the remaining 54, metastases developed in the lungs. In 1 patient metastases developed both in the lung and in retroperitoneal lymph nodes. There was no death in these groups of patients. These 10 patients with staging error and/or recurrence after RPLA have been analyzed for the causes of treatment failure utilizing a set of prognostic criteria (tumor cell type, vascular or lymphatic invasion in the primary tumor, extension to the spermatic cord, and size of the primary tumors). It has been concluded that embryonal carcinoma (P less than 0.001), vascular invasion (P less than 0.001), and extension of the tumor to the spermatic cord (P less than 0.001) are significant predictors of metastases and/or recurrence after RPLA in Stage I NSTC. A plan of management is suggested based on these criteria.

Humans↗
PubMed1986

Surgically preventable site of local recurrence of testicular carcinoma.

We report on a patient with a mixed germ cell testicular carcinoma in whom recurrence developed at the site of retained spermatic cord elements subsequent to retroperitoneal lymph node dissection. This site for recurrence can be prevented by total removal of the spermatic cord. Recurrence at this site often involves the peritoneum thus significantly reducing the survival rate. It is our policy to attach a long length of nonabsorbable suture marker material to the most proximal aspect of the spermatic cord when performing a radical inguinal orchiectomy. Such a marker facilitates the removal of the entire remaining cord if a retroperitoneal node dissection is performed.

Adult↗
PubMed1986

Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema.

From 1975 through 1983, 69 patients with hereditary angioneurotic edema were treated with danazol, a semisynthetic anabolic steroid. Hematuria developed in 13 of these patients (19 per cent). Careful evaluation of the genitourinary tract showed the presence of a distinct form of hemorrhagic cystitis in 10 patients. Clinically, 9 patients presented with microscopic and 1 with intermittent gross hematuria. Irritative bladder symptoms were reported by 2 patients. Neither the dose nor duration of danazol therapy correlated with the severity of the cystoscopic or pathological findings. Cystoscopically, a rather nonspecific pattern of erythema, submucosal telangiectasia and neovascularity was observed. Histopathologically, bladder biopsy typically showed numerous dilated submucosal vessels with hemorrhage, mucosal ulceration and occasional inflammatory cells. These changes regressed in all but 1 patient when danazol therapy was discontinued. Further studies are needed to elucidate the role of danazol itself or of the danazol-hereditary angioneurotic edema interaction in the pathogenesis of these abnormalities.

Adult↗
PubMed1986

Prognostic factors in nonseminomatous testicular cancer.

The clinical, pathological and laboratory data for 60 patients with pathological stage I, 50 with stage II and 55 with stage III nonseminomatous testicular cancer were reviewed to identify prognostic factors that may be used to guide therapeutic approaches. In patients with stage I disease the presence of embryonal carcinoma (p less than 0.001) and vascular invasion in primary tumors (p less than 0.01) are significant predictors of metastases and/or recurrence after retroperitoneal lymphadenectomy. In patients with clinical stage II disease, lymph nodes greater than 2 cm. in diameter or more than 5 in number, vascular and/or lymphatic invasion and the presence of embryonal carcinoma with or without choriocarcinoma indicated an increased risk for recurrent tumor after retroperitoneal lymphadenectomy. In patients with stage III disease the involvement of 3 or more organ systems was associated with decreased survival. Patients in this group with intrathoracic metastases smaller than 2 cm., retroperitoneal metastases less than 4 cm., normal kidneys and liver, and no evidence of yolk sac tumor or choriocarcinoma had improved survival. These observations can be used to guide the type and duration of therapy selectively in patients with nonseminomatous testicular cancer.

Humans↗