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Biomedical subjects

N Hjorth

Publications and source records attributed to N Hjorth.

At least 37 records · Page 2Linked to original sources
PubMed1985

Frictional contact dermatitis.

Frictional trauma to the palms and fingertips can provoke a dermatitis. Cases of frictional dermatitis have been recognized in workers handling large quantities of pressure-sensitive carbonless paper. Elimination of the trauma led to healing within 2-3 weeks.

Adult↗
PubMed1985

Contact sensitivity to chlorhexidine?

In a joint study, 2061 patients (1346 women and 715 men) were patch tested with chlorhexidine gluconate 1% in water, included in a standard test series. 48 patients (2.3%) showed a positive reaction. These were relatively more common in men (3.2%) than in women (1.9%). Positive reactions were most common in patients with leg eczema (6.8%) or leg ulcer (10.9%). Of the 48 patients who were patch test positive, 14 (2 with leg ulcer) were retested with chlorhexidine gluconate 0.01 and 1%. Only one with a leg ulcer was positive. These findings indicate that false positive reactions, known as "the excited skin syndrome", may arise from testing eczema patients in a standard series. The sensitizing potential of chlorhexidine may be very low, but the potential in patients with an eczema or ulcer of the leg has to be further evaluated.

Adult↗
PubMed1985

Pityrosporum orbiculare--a pathogenic factor in atopic dermatitis of the face, scalp and neck?

Pityrosporum orbiculare (pit.o.), the yeast form of Malassezia furfur, though usually considered to be a non-pathogenic saprophyte, in some individuals trigger various types of dermatitis. It is earlier shown that it is of importance in atopic dermatitis in the head-neck area in adults, and that elimination of the yeast by help of treatment with ketoconazole improve the dermatitis. In this large retrospective study of 741 patients prick-tested with an aqueous extract of pit.o., the occurrence of positive prick-test to pityrosporum was related to the patient's atopic manifestations. It was found that a positive prick-test to pityrosporum was related to active atopic dermatitis, and especially in the head-neck region. In contrast to the common allergens in the standard prick-test-series, however, pit.o. was not found to give positive prick-tests in patients with atopic conjunctivitis, rhinitis and/or asthma without active dermatitis. This finding strengthens the concept that hypersensitivity to the cutaneous microflora is of pathogenic importance in some cases of atopic dermatitis in adults.

Dermatitis, Atopic↗
PubMed1985

Topical anhydrous aluminum chloride formulation in the treatment of acne vulgaris: a double-blind study.

A randomized double-blind bilateral study of twenty-five patients with acne vulgaris showed that eight weeks' treatment with 6.25 percent aluminum chloride in anhydrous alcohol gave better results than alcohol alone (p = 0.1). Improvements were recorded with both 6.25 percent aluminum chloride in anhydrous alcohol and with placebo, but 6.25 percent aluminum chloride in anhydrous alcohol proved better after four weeks' treatment. The effect on acne of 6.25 percent aluminum chloride in anhydrous alcohol is probably due to the disinfectant and antiperspirant action of aluminum chloride whereas the effect of placebo can be assigned to the sebostatic action of alcohol. The result of this study confirms previous results of open uncontrolled studies.

Acne Vulgaris↗
PubMed1985

Pressure onycholysis in slaugtherhouse workers.

Onycholysis was found in 7 workers engaged with manual skinning of cattle. In all of them the nail problems started shortly after employment. The most likely explanation for the persistent onycholysis is work related pressure anoxia of the nailbed.

Abattoirs↗
PubMed1985

Fusidic acid plus betamethasone in infected or potentially infected eczema.

Eighty-one patients with atopic dermatitis and contact dermatitis received a 1-week treatment with 0.1% betamethasone alone on one side and 0.1% betamethasone plus 2% fusidic acid on the other side. Clinically, the combination was marginally superior and in patient preference a significant difference in favour of the combination was recorded. Bacteriologically, the combination eliminated 67% of bacteria originally present in the skin lesions compared with 51% with steroid alone.

Adolescent↗
PubMed1984

[Mechanically-induced contact dermatitis and psoriasis].

Frictional eczema seems to be quite common, as is here illustrated by means of a few examples. A post-office official showed an eczema on both palms brought on by a rough tabletop . A bus driver had an eczema of the fingertips caused by contact with tickets . Mechanically provoked psoriasis of the palms is well-known. The frequency of other frictional dermatoses, however, seems to be underestimated.

Adult↗
PubMed1984

The baboon syndrome: systemically-induced allergic contact dermatitis.

The catchword "baboon syndrome" is used to denote a characteristic distribution pattern of systemic allergic contact dermatitis. Diffuse erythema of the buttocks, upper inner surface of the thighs, and axillae are characteristic features. We describe 3 cases provoked by ampicillin, nickel and mercury. The condition may be overlooked and suspected of being a textile dermatitis or seborrhoeic dermatitis of the elderly.

Adult↗
PubMed1984

A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses.

39 patients with bilateral dermatoses, mainly psoriasis vulgaris and atopic dermatitis, were treated with 0.1% Ro 12-7024 ointment and 0.1% betamethasone valerate ointment according to a double-blind, right-left, randomized design. Treatment lasted up to 4 weeks. 5 patients did not complete the trial. Assessment of efficacy, expressed as degree of healing in percent of treated skin area and according to an overall assessment of efficacy made by both physician and patient only revealed marginal, mostly statistically insignificant differences, with a trend in favor of betamethasone. Patients' preferences for one of the two treatments favored betamethasone valerate in 17 cases and Ro 12-7024 in 5 cases; 13 cases were ties (p less than 0.001). With the exception of one case of bilateral erythema and itching no side effects were reported. The efficacy of the D-homosteroid Ro 12-7024 is evidently of the same order as that of the group III steroid betamethasone valerate, and the tolerance of the two ointments is good and equal.

Adolescent↗
PubMed1984

Meclosorb, a new topical antibiotic agent in the treatment of acne vulgaris: a double-blind clinical study.

The clinical effect on acne vulgaris of topical treatment with meclocycline sulfosalicylate and systemic treatment with peroral tetracycline (500 mg daily) was compared in a double-blind study of 60 patients treated for 8 weeks. The reducing effect of Meclosorb cream and tetracycline tablets on the number of closed comedones, pustules, papules and cysts was marked and not significantly different. The effect of Meclosorb on open comedones was weak and of slow onset. No side effects were registered. Topical treatment with Meclosorb is an effective and safe alternative to systemic tetracycline treatment of acne vulgaris.

Acne Vulgaris↗
PubMed1982

Microbial eczema of the feet.

Twenty-seven patients were investigated for eczema of the feet which mainly affected the medial interdigital spaces and the dorsal areas of the medial toes. The lesions tended to spread to the dorsum of the foot, rather than the plantar surface as seen in tinea pedis, which typically affects the lateral interdigital spaces. In all patients S. aureus and/or haemolytic streptococci were cultured, whereas scrapings for fungi were negative. All responded well to treatment aimed at eradicating bacteria and dermatitis, but relapses occurred in 33% of the cases. We believe this clinical entity is due to infective dermatitis in which the presence of bacteria provokes an eczematous response in the host, probably due to pre-existing sensitization rather than direct infection.

Adolescent↗
PubMed1982

Perioral contact urticaria from sorbic acid and benzoic acid in a salad dressing.

Contact urticaria was observed in a kindergarten in 18 of 20 children following the intake and accidental perioral application of a mayonnaise salad cream. In healthy adult controls, stinging tests and closed 20 minute patch test with the salad dressing were positive in 9 out of 12 and 4 out of 10 cases respectively. Twenty minute patch tests with the different components of the salad dressing were positive only so sorbic acid (SA) and benzoic acid (BA). Urticaria was provoked by inunction of the salad dressing periorally in two healthy boys. Serial 20 minute closed patch testing with varying concentrations of SA in 91 patients and BA in 41 patients gave almost identical results: positive reactions in two thirds of the patients with the highest concentrations. The response was only partially blocked by antihistamine applied locally before testing. Non-immunologic mechanisms are probably responsible for the transient reaction, and no restriction in the extensive use of SA or BA as preservatives in food should be considered.

Adolescent↗