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Biomedical subjects

N Furuhashi

Publications and source records attributed to N Furuhashi.

At least 73 records · Page 4Linked to original sources
PubMed1983

Cord serum growth hormone in the human fetus. Sex difference and a negative correlation with birth weight.

Cord venous growth hormone (GH) were measured by radioimmunoassay in 88 infants and 11 anencephalic infants. The mean GH levels decreased gradually from midgestation, preterm to term fetus. There was a significant (p less than 0.01) sex difference in the GH level of term fetuses. Anencephalic infants had low GH levels. There was a significant (p less than 0.01) negative correlation between the cord GH level and birth weight in the normal infant. These data suggest that there is a sex difference for fetal GH secretion and that GH is not so important for fetal growth, but the hypothalamus plays an essential role in the regulation of fetal GH secretion.

Anencephaly↗
PubMed1983

Human ACTH, beta-lipotropin and beta-endorphin levels in maternal plasma at delivery.

Adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-EP) were measured simultaneously in maternal plasma at delivery. Mean concentrations of beta-LPH and beta-EP in maternal plasma at delivery were significantly higher than those in normal control. There were significant positive correlations among ACTH, beta-LPH and beta-EP concentrations, respectively. These data suggest that beta-LPH and beta-EP were elevated during delivery and in parallel with each other.

Adrenocorticotropic Hormone↗
PubMed1983

Changes of serum gonadotropin levels and sex differences in premature and mature infant during neonatal life.

We measured FSH and LH concentrations by RIA in 130 cord sera and 213 peripheral sera obtained as serially as possible from 67 infants who were 5-75 days old and were born between the 28th and 42nd gestational weeks. Cord serum FSH and LH (+hCG) levels were 3.9-13.6 mIU/ml and 43.3-88.6 mIU/ml, respectively; they decreased with advancing gestational age. Postnatal FSH levels in male infants maintained low levels (3.7-8.7 mIU/ml). However, those in female infants increased with peak levels (51.8-270.3 mIU/ml) between 11 and 30 days after delivery, and then decreased; the surge was more marked and prolonged in preterm infants than in term infants. Postnatal LH levels in both sexes decreased rapidly after birth, which may be due to a decrease of placental hCG, and thereafter displayed patterns similar to FSH levels. We found a significant sex difference of serum gonadotropin levels in newborn infants and differences between term and preterm infants. Our results suggest that the sex difference of pituitary gonadal function exists and that the function matures during the fetal and neonatal life.

Chorionic Gonadotropin↗
PubMed1983

Simultaneous measurement of human prolactin and growth hormone levels in maternal and fetal serum and amniotic fluid.

Growth hormone (GH) and prolactin (PRL) in maternal and fetal serum and amniotic fluid were measured simultaneously by radioimmunoassay at term deliveries of 20 normal mothers. The PRL level of amniotic fluid was significantly higher than that of maternal and fetal serum. The fetal GH level was significantly higher than the maternal and amniotic levels of GH. There was no significant correlation among hormone levels of maternal and fetal sera and amniotic fluid. These data suggest that PRL and GH levels of maternal and fetal sera and amniotic fluid are controlled separately.

Amniotic Fluid↗
PubMed1983

The effect of sulpiride administration on maternal and fetal plasma prolactin levels, and fetal growth in rats.

Pregnant Wistar rats were daily injected with 5 mg sulpiride into the peritoneal cavity starting on day 14 of gestation. Blood samples were obtained from the maternal carotid artery and fetal axillary vessels on day 20 of gestation. Serum prolactin (PRL) levels were determined by radioimmunoassay using a rat PRL RIA kit. The maternal serum and fetal plasma PRL levels were significantly higher in the sulpiride-treated group than in the saline control group. There was a significant positive correlation between fetal body weight and fetal plasma PRL level. These results suggest that sulpiride which reached the fetus stimulates fetal PRL secretion and that PRL may exert a growth-promoting effect on the fetus.

Animals↗
PubMed1983

Human plasma ACTH, beta-lipotropin and beta-endorphin during delivery.

Adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-EP) immunoreactivities were measured by high sensitive radioimmunoassay in maternal and umbilical cord plasma samples which were obtained simultaneously in 12 cases. Mean ACTH levels in cord and maternal plasma were significantly higher than those of 8 normal adults. Mean beta-EP to beta-LPH molar ratio of 0.19 in maternal plasma was different from that of cord plasma (0.13). There was no significant correlation between beta-EP levels, or between beta-LPH levels, in the paired fetal and maternal samples. These data suggest that beta-LPH and beta-EP elevate during labor and delivery in response to the stress. Beta-LPH and beta-EP in cord plasma are of fetal and/or placental origin.

Adrenocorticotropic Hormone↗
PubMed1983

Further characterization of the dioxin receptor in the rat deciduoma.

The rat deciduoma cytosol contains a protein which binds radio-labeled dioxin and sediments as an 8-9 S entity on 10-40 per cent (w/v) sucrose density gradients. Incubation of cytosol with [3H]-TCDD at 37 degrees C for ten minutes shifted the sedimentation coefficient from 8-9 S to 4-5 S, whereas incubation of cytosol at room temperature for 30 minutes has no effect on the S value. At high concentrations of [3H]-TCDD the dioxin receptor complex tends to aggregate. Cytosol eluted with 0.25 M KCl from a DEAE cellulose column and complexed with [3H]-TCDD sedimented at 9S in low ionic strength buffer, but sedimented slower (5S) in the presence of 0.4 M KCl in the buffer. The effect of salt and temperature on the sedimentation behavior is compared with that of steroid receptors. The usage of DEAE cellulose column chromatography in purification of the receptor complex is also discussed.

Animals↗
PubMed1983

[A study on testosterone secretion in neonates].

Serum testosterone (T) concentrations in 106 umbilical venous bloods and 104 neonatal venous bloods, which were obtained from preterm (32-36w) and term (36-41w) infants, were measured by RIA. Cord T levels of boys were higher in preterm infants than in term infants, and those of preterm infants were higher in boys than in girls. Neonatal T levels of girls decreased following delivery. But those of boys increased after 10 days of life. T levels were higher in boys than in girls at 11-30 days of life. Differences between preterm and term infants were not significant.

Female↗
PubMed1983

[Studies on the cortisol levels in maternal vein, umbilical artery, and umbilical vein classified according to the mode of delivery].

We measured maternal venous(MV), umbilical arterial(UA), and umbilical venous(UV) cortisol levels of 180 pregnancies at term. In vacuum extraction cases, the cortisol levels of three individual samples were significantly higher than in other modes of delivery. In cesarean section delivery the cortisol levels of three individual samples were the lowest of all modes of delivery. The cortisol level of MV was higher than that of UA and UV in all deliveries. The cortisol levels of three samples showed no difference between the induced labor group and the spontaneous onset of labor group regardless of the delivery mode. In spontaneous vaginal delivery the cortisol levels of three individual samples were significantly higher in primipara than in multipara. Positive correlation was observed in all modes of delivery between the cortisol levels of MV & UA, MV & UV, and UA & UV. There was a negative correlation between the cortisol levels of MV and umbilical arteriovenous cortisol difference in multipara spontaneous vaginal deliveries. There was also a negative correlation between cortisol levels of MV and the umbilical arterial/venous ratio. These data suggest that the fetus may produce cortisol by itself and maternal cortisol may inflow to the fetus.

Female↗
PubMed1983

[Studies on cortisol levels in the maternal vein, umbilical artery, and umbilical vein in cases of fetal distress and neonatal asphyxia].

We measured maternal venous (MV), umbilical arterial (UA) and umbilical venous (UV) cortisol levels of 180 pregnancies at term, and investigated especially cases of fetal distress and neonatal asphyxia. No fetal distress and no neonatal asphyxia cases followed spontaneous vaginal deliveries (94), cesarean sections (18) or breech extractions (6). In cesarean section delivery, the cortisol levels of three individual samples were lower than in other modes of deliveries. The cortisol level of the umbilical artery was significantly higher than that of the umbilical vein in spontaneous vaginal delivery and cesarean section delivery. When spontaneous vaginal deliveries were classified into the fetal distress group and no fetal distress group, the cortisol levels of the umbilical artery and umbilical vein in the former group were significantly higher than those in the latter group. Furthermore, regardless of fetal distress there were significant positive correlations between the cortisol levels of MV & UA, MV & UV, and UA & UV. In addition, as the cortisol level of the maternal vein increased, the umbilical arterial-venous cortisol ratio (UA/UV) gradually approached 1.0. These data suggest that in fetal distress or neonatal asphyxia, the fetus may produce cortisol for itself independent of the mother.

Asphyxia Neonatorum↗
PubMed1982

Correlation of birth weights with umbilical cord serum LH-hCG, FSH, beta-hCG, Estradiol, Cortisol and Testosterone levels.

Luteinizing hormone-human chorionic gonadotropin (LH-hCG), follicle-stimulating hormone(FSH), beta-human chorionic gonadotropin (beta-hCG), estradiol, cortisol and testosterone levels were determined in cord venous serum and the correlation of birth weights with those hormone levels was investigated in 32 male and 35 female fetuses. There were significant negative correlations between LH-hCG or FSH levels and birth weights in the male fetus. Also there was a significant positive correlation between LH-hCG levels and birth weights in the female fetus. This data suggests that there is a sex difference during the development of the pituitary-gonadal axis.

Birth Weight↗
PubMed1982

Cytoplasmic estrogen receptors of rat mammary glands during pregnancy and puerperium.

The variation of cytoplasmic estrogen receptor in the mammary gland during pregnancy and puerperium was studied to determine the role of estrogens in the mechanism of lactation. Cytosol estrogen receptors from rat mammary glands were incubated with 3H-estradiol, and the free estradiol was removed using dextran-coated charcoal. The maximum number of binding sites in the cytosol was estimated from saturation curves and Scatchard analysis. During pregnancy the number of binding sites was relatively low (2.5 to 3.8 pmoles per mg protein), but increased after delivery to 7.8 pmoles per mg protein. The number of estrogen binding sites in the mammary glands of lactating rats five days after delivery was at the same level as on the day of delivery. However, at ten days after delivery the number of binding sites increased markedly to 58.9 pmoles per protein. The number of estrogen-binding sites in the mammary glands of lactating rats was decreased by castration and by the injection of testosterone or 2-bromoergocriptine. There appeared no competition by testosterone, progesterone or cortisol with estrogen receptors in the mammary gland.

Animals↗
PubMed1982

Clinical background of preeclampsia in Japanese women.

In Japan, the maternal mortality rate from preeclampsia is still high. In this study, we analyzed the clinical background of 70(1.5%) cases of severe preeclampsia in 4,633 deliveries in our clinic. The main family history was hypertension (34.2%). The medical complication of this pregnancy were nephritis (11.4%), hypertension (5.7%) and diabetes mellitus (4.3%). In previous obstetrical complication, preeclampsia was found very high frequency (44.4%). In this pregnancy, the cesarean section was done for 15 (21.4%) cases. There was a significant high frequency of low birth weight infant in preeclampsia (2,400 +/- 925 gr, mean +/- S.D.). The stillbirth was found in 12 (17.1%) cases. The perinatal mortality rate was 169/1,000 deliveries, this was a significantly higher than total rate (15/1,000 deliveries). These data suggest that it is important to control medical complications before to be pregnant to prevent preeclampsia.

Diabetes Mellitus↗
PubMed1982

[Plasma ACTH, beta-lipotropin and beta-endorphin in the human fetus and their mother during delivery (author's transl)].

Adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) immunoreactivity (IR) and beta-endorphin (beta-EP) immunoreactivity (IR) were measured by high-sensitive radioimmunoassay in maternal and umbilical cord plasma samples which were obtained simultaneously in 12 cases. Mean IR-beta-LPH in maternal (690.1 +/- 138.6 pg/ml, +/- S.E.) and cord venous plasma (1114.8 +/- 94.2 pg/ml) were significantly higher than that of normal adults (93.0 +/- 8.2 pg/ml). Mean IR-beta -EP in maternal (125.8 +/- 24.0 pg/ml) and cord venous plasma (130.6 +/- 20.6 pg/ml) were significantly higher than that of normal adults (6.0 +/- 0.9 pg/ml). There were significant positive correlations between IR-beta-LPH and IR-beta-EP in maternal and cord venous plasma. Mean beta-EP to beta-LPH molar ratio of 0.19 +/- 0.03 in maternal plasma was significantly (p less than 0.05) higher than that of cord venous plasma (0.13 +/- 0.01). There was no significant correlation between the levels of these three hormones in maternal plasma and the levels in cord venous plasma. These data suggest that ACTH, IR-beta-LPH and IR-beta-EP were elevate during labor, delivery responding the stress. Beta-LPH and beta-EP in cord venous plasma were fetal and/or placental origin.

Adrenocorticotropic Hormone↗