Teratoma in the head and neck region is very rare. We treated a child with a mature congenital teratoma that arose from the right sphenoidal sinus. He is doing well after early surgical treatment with endoscopic endonasal resection of the tumor.

Endoscopy↗

PubMedDate not supplied

MR imaging of spinal cord in Devic disease.

A 20-year-old man with typical features of Devic disease was studied with magnetic resonance (MR) demonstrating sequential changes of the spinal cord from swelling to atrophy. A good correlation between neurological findings and MR imaging was documented.

Adult↗

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Genetic heterogeneity of combined gastric and duodenal ulcers detected by pepsinogen C gene polymorphism.

It has been reported recently that there was genetic heterogeneity in gastric ulcer disease depending upon the location of the ulcer, and that there was a significant association between the restriction fragment length polymorphism (RFLP) for pepsinogen C (PGC) gene and gastric body ulcer. In the present study, the association of the RFLP for PGC gene with combined gastric and duodenal ulcers was investigated to analyse genetic factors in its aetiology. Eighty unrelated controls and 47 patients with combined gastric and duodenal ulcers were studied. The allele frequencies of the large (3.6 kilobase EcoRI fragment) and the small fragment (3.5 kilobase EcoRI fragment) were, respectively 80.6 and 19.4% in controls, 60.0 and 40.0% in patients with combined gastric body and duodenal ulcers, 69.0 and 31.0% in patients with combined gastric angular and duodenal ulcers, and 81.8 and 18.2% in patients with combined gastric antral and duodenal ulcers. The allele frequency of the small fragment was significantly higher in patients with combined gastric body and duodenal ulcers than in controls. The genotypes that possessed the small fragment were significantly more frequent in patients with combined gastric body and duodenal ulcers (66.7%) than in controls (33.8%) and combined gastric antral and duodenal ulcers (27.3%). These results suggest that there is genetic heterogeneity in combined gastric and duodenal ulcers depending upon the location of gastric ulcer, and that combined gastric body and duodenal ulcers are associated with the small fragment allele of the PGC RFLP in the same way as solitary gastric body ulcers.

Blotting, Southern↗

PubMedDate not supplied

A biography and bibliography: the recent trends in bioethics and medical genetics in Japan (Part I).

1. Introduction. 2. History of Bioethics in Japan. 3. First international bioethics seminar in Fukui on human dignity and medicine (1987). 4. Second international bioethics seminar in Fukui--international association of human biologists--japan society of human genetics joint symposium on medical genetics and society (1990). 5. Third international bioethics seminar in Fukui on human genome research and society (1992). 6. Fourth international bioethics seminar in Fukui on intractable neurological disorders, human genome research and society (1993). 7. Fifth international bioethics seminar in Fukui on the MURS japan/IBC UNESCO joint seminar on the protection of the human genome and scientific responsibility (1995). 8. Sixth international bioethics seminar in Fukui--UNESCO Asian bioethics conference- and who assisted satellite symposium on medical genetics services and bioethics, in Kobe and Fukui (1997). 9. Coming seventh international bioethics seminar in Fukui on pharmaco-genomics and DNA polymorphism (2000). 10. Conclusion.

Bioethics↗

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A biography and bibliography: the recent trends in bioethics and medical genetics in Japan (Part II).

At the present, we have much misunderstandings and prejudices, connected with psychological conflicts for the direct application of cloning and of prenatal diagnosis and selective abortion. So that we should have much debates among general public on further direction of these researchs, in order to study on safe-guard and public understandings. Summarinzingly, in order to educate general public in their understanding of ELSI problems, we should remove the boundaries between individuals, in professional and non-professional fields, and in developed and developing countries, and give more time for medical curriculum for medical genetics and bioethics, in order to educate general public, as well as scientific responsibility in our society. Finally, we hope these recommendations and reports will help the International Bioethics Seminars in Fuki on 2000 for the follow up study on Universial Declaration of Human Genome and Rights, with new technologies on pharmacogenomics DNA polymorphisms as well as our ethical debates on international research ethics, proposed at the International Bioethics Summit.

Bioethics↗