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N Dourov

Publications and source records attributed to N Dourov.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

[Resorbing granulomatous process at the contact with the corpuscles of Hassall. Histopathologic aspects].

A histopathologic study of the thymus in human allowed in 14 cases to give evidence of a granulomatous process with macrophages and multinucleate giant cells. These cells are seen at the contact with the corpuscles of Hassall. They dissociate the structure of the latter and contribute to their disappearance. These resorptive granulomatous phenomena illustrate an ill-known aspect of the dynamism of the corpuscles of Hassall.

Granuloma↗
PubMedDate not supplied

Cytochemical identification of HSP110 during early mouse facial development.

Apoptotic cell death constitutes a common phenomenon observed during development. This process plays an important role in the regulation of cell populations and in early differentiation of embryonic organs. Several teratologic situations are considered as resulting in a dramatic increase of the apoptotic process. In mammalian cells, heat shock proteins (HSPs), expressed or increased in response to various stresses, act as molecular chaperones in physiological conditions. In order to determine specific histochemical markers of apoptotic cells in normal craniofacial development, we observed the expression of stress proteins (HSPs) 70, 86, and 110. The apoptotic pattern of mesectodermal cell death areas was confirmed using both nuclear staining (Feulgen) and specific labeling of DNA fragmentation (TUNEL). These areas are localized in the proximal parts of the first and second visceral arches. They are located in mesectodermal and ganglionic cells. Apoptotic mesectodermal populations strongly express HSP110, as shown by the cytochemical identification of HSP110 and by double staining HSP110-TUNEL, suggesting that this protein could be considered as a new marker for apoptotic embryonic cells, and could be used in further teratologic studies to better quantify induced cell death.

Animals↗