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Biomedical subjects

N Buchanan

Publications and source records attributed to N Buchanan.

At least 163 records · Page 9Linked to original sources
PubMed1978

Cerebrospinal fluid acid-base balance in patients with severe injuries living at an altitude of 1 660 metres.

Cerebrospinal fluid (CSF) acid-base balance in 40 control subjects and 40 patients with head injuries was studied at an altitude of 1 660 m. The patients with head injuries showed a significantly lower CSF pH associated with a fall in CSF bicarbonate and an elevation of CSF lactic acid. The cause of these observations is unclear, but it is proposed that this may be related to the relative hypoxaemia associated with an altitude of 1 660 m.

Acid-Base Imbalance↗
PubMed1978

Protein binding of drugs--the clinical significance.

Drug-protein binding is reviewed from a clinical and practical point of view. Commonly used drugs are discussed and the effects of disease, drug dosage and hypoalbuminaemia on drug-protein binding are reviewed. Doses of highly bound (greater than 80%) drugs in patients with hypoalbuminaemia, liver disease or renal failure should be regularly reviewed.

Adrenal Cortex Hormones↗
PubMed1978

Length of survival after cardiac resuscitation in an intensive care unit.

Seventy-four patients were admitted after cardiac resuscitation to a general intensive care unit; 19, of whom 14 were neurologically normal, were utimately discharged from hospital. It is suggested that elderly patients, those who have had prolonged resuscitation, and patients with a combination of hypothermia, coma, dilated pupils, and apnoea have a very poor prognosis. It is doubtful whether such patients benefit from admission to an intensive care unit.

Acid-Base Imbalance↗
PubMed1978

Drug kinetics in protein energy malnutrition.

Potential problems of drug metabolism in human protein energy malnutrition (PEM) are reviewed in the light of the pathophysiological changes seen in PEM. Data derived from human studies and animal experiments are discussed, and a plea is made for further research in this area.

Animals↗
PubMed1978

The value of serum drug concentration assays in clinical practice.

The value of serum drug assays in clinical practice is assessed, and it is concluded that, except in neonates, elderly persons or patients with hepatic and renal dysfunction, such assays are of little clinical value. However, research projects to obtain clinically applicable pharmacokinetic data are of great value. Routine clinical drug assays should be discouraged on clinical, practical and economic grounds.

Adult↗
PubMed1978

The I.C.U. treatment of acute laryngotracheobronchitis in a developing country.

The management of 50 children with acute laryngotracheobronchitis (LTB) in a general I.C.U. in a developing country is presented. The overall mortality was 16%, with no patient demising from LTB. It is stressed that LTB in developing countries is a very different disorder to that seen in Western societies, due to complicating factors such as bronchopneumonia, malnutrition and measles. Guidelines for therapy are proposed.

Bronchitis↗
PubMed1978

Drug utilization in a general intensive care unit.

Drug utilization in 200 general ICU patients was retrospectively studied. One hundred and two different drugs were prescribed with a mean of 7.0 +/- 4.6 drugs/patient. The potential for polypharmacy and drug interactions is discussed, as is the cost of such therapy.

Adolescent↗
PubMed1977

Nursing staff stress in an intensive care unit.

The stresses associated with nursing in an intensive care unit were assessed. A comparison was drawn between a group of Black and a group of White nurses. Proposals aimed at reducing the observed stress patterns are suggested.

Black or African American↗