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N A Probatova

Publications and source records attributed to N A Probatova.

At least 37 records · Page 2Linked to original sources
PubMed1989

Chromosomal characteristics of malignant lymphoma.

Results of a cytogenetic and morphological study of 60 malignant lymphomas (ML) are presented. The most often observed chromosome abnormalities were rearrangements involving 14q32, 11q13, 11q21-23, 6q15, 6q21, 12p11-12, 17p11-12, and extra chromosomes 18, 3, 21 and 7. Translocations involving 14q32, leading to the appearance of marker 14q+, were noted in 41% of the tumors. Strict correlations between karyotype and morphology of ML were not seen. However, rearrangements of 11q were mostly found in low-grade tumors and markers 6q- in high-grade tumors. The absence of t(14;18), which is regarded to be the most common abnormality in ML, and an unusually high incidence of t(11;14) in our series confirm the uneven geographical distribution of ML with these translocations. Chromosome abnormalities in ML and acute lymphoblastic leukemia are compared.

Adolescent↗
PubMed1989

[The clinical characteristics of hematosarcoma with primary skin involvement].

As many as 90 patients suffering from hematosarcomas associated with primary skin lesions were examined. This patients' group did not include patients with mycosis fungoides or with Sezary's syndrome. The clinical picture, ways and stages of the spreading of skin hematosarcomas were reviewed. Damage to the internal organs outstripped lymph nodes injuries in 1/3 of the patients. Half of the patients followed up until their death died at the height of acute leukemia. The survival appeared relatively high: the median period turned out to be 51 months, whereas 33% of the patients survived for 10 and more years. The survival was influenced by the sex and age of the patients as well as by the histological disease variant.

Adolescent↗
PubMed1989

[Pathologic anatomy of subtypes of immunoblastic lymphosarcoma].

Morphological parameters for immunoblastic lymphosarcoma (IL) subtypes: plasmocytic IL (PIL) and polymorphocellular IL (PMIL) were determined through a comparative morphological analysis of 56 sections and 64 respective diagnostic biopsies. PIL was found to more frequently affect the gastrointestinal tract. Tumors were found to be selective in damaging the organs, e.g. white pulp was affected in PIL, marginal follicular areas, in PMIL. Clinical and anatomical analyses of the death causes in patients with IL showed that they all had died of neoplastic progression (67.9%), concurrent diseases (23.2%) or complications resulted from the therapy performed (8.9%) upon tumor progression.

Adolescent↗
PubMed1989

[The immunology of CD4-negative skin hematosarcomas].

A wide panel of monoclonal antibodies to hematopoietic cell differentiation antigens was applied to the study of CD4-negative skin hematosarcomas on cryostat secretions. The most frequent CD4-negative type was the B-cell one identified in 6 of 10 cases. In this type the use of monoclonal antibodies in addition to standard immunoglobulin markers seemed to be very important. T-cell type (CD3+ CD8+), histiocytic variant (CD11+Ia+), pseudolymphoma (polyclonal markers pattern), and Kaposi's sarcoma (hematopoietic cell negative antigen) were identified in 1 case each. The authors emphasize the importance of immunological studies of hematosarcomas because of the high frequency of the generalization of B-cell lymphomas; such studies may also help in the differential diagnosis between pseudolymphoma and hematosarcoma.

Adolescent↗
PubMed1988

[Leukemization of hematosarcomas with primary involvement of the skin].

Clinicomorphological investigation of 81 patients with different types of skin hematosarcomas was conducted. Stage IV of disease was diagnosed in 53 patients, leukemic involvement developed in 18 of them (34%). Leukemic bone involvement was shown to be the main cause of death in myelosarcomas and lymphoblastic lymphomas. There were no significant differences in the frequency of leukemic bone marrow involvement with relation to the site and nature of primary skin involvement. A clinical course of disease was determined by a skin tumor histological type. Some morphological features of bone marrow lymphoblasts in leukemic bone marrow involvement in skin hematosarcomas (irregular cell shape, a moderate nuclear-cytoplasmic ratio, azurophilic granulation, fine-grained patterns of PAS-positive substance) distinguished them from lymphoblasts in leukemic bone marrow involvement in hematosarcomas with a primary focus of another site.

Bone Marrow↗
PubMed1988

[Immunoblastic lymphosarcoma in chronic lympholeukemia and prolymphocytic lymphosarcoma (Richter's syndrome)].

Available are three cases of Richter's syndrome, i.e. immunoblastic lymphosarcoma with plasmocytic differentiation which developed in patients with chronic lymphocytic leukemia and prolymphocytic (lymphocytic) lymphosarcoma. Clinical, anatomical and autopsy findings are analysed. The immunoblastic lymphosarcoma is suggested to arise either because of transformation of the tumor prolymphocytes (lymphocytes) due to the disease progression or can be promoted by a second tumor.

Female↗
PubMed1985

[Pathological anatomy of Lennert's lymphoma].

Characterization of Lennert's lymphoma morphological substrate is given on the basis of analysis of 32 biopsies (from 22 patients) and 6 autopsy cases studied histologically, histochemically and immunomorphologically. Morphological features of a progressing disease and transformation into the immunoblastic lymphosarcoma are described. The "prelymphomatous" nature of Lennert's lymphoma is suggested taking into consideration morphofunctional characteristics of the infiltrate cells, transitory properties of peculiar morphological changes and a frequent outcome into the immunoblastic lymphosarcoma of a B-cell genesis.

Adult↗
PubMed1984

[Pathology of mitosis in clinical oncomorphology].

The results of studies of the mitosis pathology performed for many years on the material of tumour biopsies are summarized. It is shown that the determination of the tissue mitotic regimen is a theoretically founded method of cytological analysis that gives the pathologist a possibility for a more objective morphological diagnostics of pretumourous conditions and malignant tumours. The availability of this method makes it possible to recommend its wide use in the clinical oncomorphology provided the conditions assuring the minimal alteration of dividing cells (early fixation and cutting of the material) are strictly respected.

Carcinoma in Situ↗
PubMed1984

[Changes in the variant of acute leukemia].

The authors describe a female patient with acute lymphoblastic leukemia. After the first chemotherapy cycle according to the VAMP program the patient developed a complete remission. Further on, repeated extramedullary relapses (neuroleukemia, involvement of the mammary gland tissue and lymph nodes of the mesentery) were observed over 7 years, the data of blood and bone marrow analyses being within normal. At the end of the disease the patient developed a relapse with changes in the blood and bone marrow, however the blast cells were sudan and peroxidase-positive i.e. could be classified as myeloblasts.

Adolescent↗
PubMed1981

[Mitotic regimen of different histological variants of lymphosarcoma].

Mitotic regimen of lymphosarcoma (75 observations), angiofollicular hyperplasia (5) and reactive hyperplasia of lymph nodes of the follicular type (34 observations--a group for comparison) was studied. The mitotic regimen values of non-Hodgkin's malignant lymphomas were found to vary in accordance with the morphological variant of the tumor. A higher mitotic activity in combination with high frequency and diversity of forms of mitosis pathology was typical of lymphoblast and immunoblast lymphosarcomas only. Prolymphocytic lymphosarcomas showed a relatively low mitotic activity. Lymphosarcoma with nodular growth showed a considerable decrease in mitotic activity as compared with nodular reactive hyperplasia. The emergence of multipolar mitoses is a reliable diagnostic sign of nodular lymphosarcoma.

Adolescent↗