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Matthew J Budoff

Publications and source records attributed to Matthew J Budoff.

At least 55 records · Page 3Linked to original sources
PubMed2005

Plasma homocysteine predicts progression of atherosclerosis.

UNLABELLED: MINI ABSTRACT: Three emerging risk factors potentially useful in predicting future cardiac events are electron-beam computed tomography (EBT), homocysteine(HCY), and C-reactive Protein (CRP). We evaluated a cohort of 133 serial asymptomatic patients, who underwent two consecutive EBT scans (8-84 months apart) and a comprehensive cardiac risk factor assessment, including measurements for lipids, ultrasensitive CRP and homocysteine. Individuals with elevated HCY (> or =12 micromol/L) demonstrated a mean increase in CC progression of 35% per year, while those with HCY <12 micromol/L (median) progressed at 17% per year (p = 0.0008). Patients with a level equal to or lower than the median value of CRP (0.8 mg/L) had a median yearly progression of 22%, compared to 21% for those with CRP value = 0.9-11 mg/L (p = ns). Presence of elevated HCY (>12 micromol/L) strongly and independently predicts progression of coronary plaque burden. BACKGROUND: Despite the availability of effective preventive therapies, coronary artery disease (CAD) remains the leading cause of morbidity and mortality. Use of traditional cardiovascular risk factors is imprecise and predicts less than one half of future cardiovascular events. Three 'emerging risk factors', as potential means of identifying subclinical atherosclerosis and predicting future cardiovascular events, are electron-beam computed tomography, homocysteine, and C-reactive protein. Given the evidence that HCY and CRP are involved in atherogenesis, we hypothesized that significant progression of EBT calcium score (a measure of atherosclerotic plaque burden) is associated with higher levels of these markers. METHODS: We evaluated 133 asymptomatic patients (100 men, 33 women; mean age was 61 +/- 9 years) who underwent previous EBT calcium score testing at Harbor-UCLA 8-80 months prior to enrollment (mean follow-up 20 months). Exclusion criteria included those with known or symptomatic CAD and chronic renal disease. During enrollment, we measured risk factors, serum HCY, serum lipids, ultrasensitive-CRP, and repeat EBT calcium scan. Statistical analysis was performed using probable Chi square method, and Student's t-test. RESULTS: Individuals with elevated HCY (> or =12 micromol/L) demonstrated a mean increase in CC progression of 35% per year, while those with HCY <12 micromol/L (median) progressed at 17% per year (p = 0.0008). Patients with a level equal to or lower than the median value of CRP (0.8 mg/L) had a median yearly progression of 22%, compared to 21% for those with CRP value = 0.9-11 mg/L (p = ns). Neither cholesterol values, body mass index, gender, age nor presence of individual risk factors predicted progression of coronary calcium. CONCLUSION: Presence of elevated HCY (>12 micromol/L) strongly and independently predicts progression of coronary plaque burden.

Adult↗
PubMed2005

Effects of hormone replacement on progression of coronary calcium as measured by electron beam tomography.

PURPOSE: The recent Women's Health Initiative (WHI) results have demonstrated that combined estrogen plus progestin imparts a small but significant increase in cardiovascular risk and breast cancer among asymptomatic women. However, the effect and potential benefit of unopposed estrogen is not as clear. We sought to evaluate the progression of subclinical atherosclerosis in postmenopausal women using no hormone replacement therapy (HRT), combined therapy, and estrogen alone in an observational study. METHODS: Postmenopausal women without symptoms or known coronary heart disease (CHD) were evaluated at our center for follow-up of coronary calcification. Patients were physician referred and underwent two consecutive electron beam tomography scans at least 1 year apart. All women fitting the study criteria were asked to participate, and those who consented were included. Demographic data, risk factors for CHD, HRT, and other medication use were collected by interview. RESULTS: The study included 177 asymptomatic women. Calcium progression was 14.6%+/-21% in women taking any hormone therapy (n=97). Annual calcium progression rates in nonusers (n=80) was 22.3%+/-32%. Relative to the nonuser group, HRT treatment inhibited the progression of atherosclerosis by 35% (p=0.01). This effect was independent of age, risk, cardiovascular factors, statin use, or baseline CAC score. Thirty-five of the 97 women (36%) were taking estrogen plus progestin, with an annual increase in calcium scores of 24%+/-23%, similar to the non-HRT women (22%). Those women taking estrogen replacement only (n=62) was 63% lower (9%+/-22%). CONCLUSIONS: This is an observational study, and the results are in accordance with the recently published WHI study, demonstrating no benefit of estrogen plus progestin compared with no therapy. However, women taking unopposed estrogen demonstrated a significant slowing of subclinical atherosclerosis compared with non-HRT and estrogen plus progestin.

Adult↗
PubMed2005

Noninvasive coronary angiography using computed tomography.

While noninvasive imaging of the coronary lumen remains challenging, great strides have been made with computed tomography. Two variations of computed tomography are used in the study of the coronary tree: multislice or multidetector computed tomography and electron-beam computed tomography. Both have high spatial and temporal resolutions as well as excellent signal-to-noise ratios, which allows major branches of the coronary tree to be depicted. Impaired image quality, due to dense calcifications and multiple image artifacts including coronary artery motion and breathing artifacts, limits the clinical utility of noninvasive coronary angiography. Early studies with electron-beam angiography demonstrated an overall sensitivity of 85% and specificity of 89% for the detection of obstructive coronary artery disease. With early diastolic imaging, the sensitivity and specificity increases to 92 and 93%, respectively (rather than 80% of the cardiac interbeat interval, where coronary motion is more pronounced). Multidetector computed tomography, with improved spatial resolution but decreased temporal resolution, produces results that vary depending on the equipment. Four-slice scanners have an average sensitivity of only 61%, and only 38% of patients have all four vessels or 15 segments available for analysis, due to both cardiac motion and calcification. Thinner slice collimation with eight and 16 slices have allowed for improved detection. Sensitivity and specificity improve to 80 and 86%, respectively. Furthermore, the number of assessable segments with eight-to 16-slice scanners improves significantly, compared with four-slice scanners (85 vs. 73%; p<0.001). If only assessable segments are included in analysis, sensitivity and specificity for multidetector-row computed tomography improves to nearly 90%. Compared with magnetic resonance imaging, with a reported accuracy of 72% in the only multicenter study, computed tomography has great promise to become the primary method of noninvasive coronary angiography.

Coronary Angiography↗
PubMed2005

Computed tomographic cardiovascular imaging.

The chapter presents the Cardiac CT for the assessment of cardiovascular pathology with an emphasis on the detection of coronary atherosclerosis. Cardiac CT is a robust technology for the non-invasive assessment for a spectrum of cardiovascular disease processes. This imaging modality can provide assessment of atherosclerotic plaque burden and coronary artery disease risk through coronary calcium scoring. Advances in spatial and temporal resolution, electrocardiographic triggering methodology, and image reconstruction software have helped in the evaluation of coronary artery anatomy and vessel patency, providing the ability to noninvasively diagnose or rule out significant epicardial coronary artery disease. This technique also allows the 3-Dimensional simultaneous imaging of additional cardiac structures including coronary veins, pulmonary veins, atria, ventricles, aorta and thoracic arterial and venous structures, with definition of their spatial relationships for the comprehensive assessment of a variety of cardiovascular disease processes.

Coronary Angiography↗
PubMed2004

Coronary artery calcification and family history of premature coronary heart disease: sibling history is more strongly associated than parental history.

BACKGROUND: The objective of the study was to assess the association of a family history (FH) of premature coronary heart disease (CHD) with coronary artery calcification (CAC) in asymptomatic individuals and to compare the effects of sibling or parental FH on the risk of subclinical atherosclerosis. METHODS AND RESULTS: CAC by electron beam tomography was performed in 8549 asymptomatic individuals (69% men; mean age, 52+/-9 years). The prevalence and odds of any CAC and extent of CAC stratified according to FH of premature CHD were determined. Those with (1) no FH of CHD, (2) FH of premature CHD in parents, or (3) FH in siblings had a prevalence of CAC of 55%, 64%, and 78% (P<0.0001) among men and 27%, 36%, and 56% (P<0.0001) among women, respectively. The multivariate regression analysis demonstrated that the odds ratio (95% confidence interval) for the presence of CAC was 1.3 (1.1 to 1.6) among those with positive FH of premature CHD in parents only, 2.3 (1.7 to 3.1) and 2.5 (1.8 to 3.3) among those in siblings and a combined FH compared with those without FH of CHD in men, respectively. Among women, the corresponding odds ratios were 1.3 (1.0 to 1.8), 2.3 (1.7 to 3.6), and 1.9 (1.3 to 3.1), respectively. A similar trend was observed in the association of FH of premature CHD with increasing CAC scores. CONCLUSIONS: Our study demonstrates a highly significant association between FH of premature CHD and the presence and extent of CAC. Furthermore, within the limits of self-reporting of family history, our findings suggest that a sibling history is more strongly associated with subclinical coronary atherosclerosis than a parental history of premature CHD.

Adult↗
PubMed2004

Baseline heart rate-adjusted electrocardiographic triggering for coronary artery electron-beam CT angiography.

Conventional electrocardiographic (ECG) triggering (group 1, 53 patients) was compared with baseline heart rate-adjusted ECG triggering (group 2, 54 patients) for coronary artery electron-beam computed tomographic (CT) angiography. CT angiographic data sets were compared blindly with conventional angiograms according to segment. Nonassessability of coronary artery segments was reduced from 35% in group 1 to 13% in group 2 (P < .001). More motion-free coronary artery images were obtained in group 2 than in group 1, especially in the right coronary artery (95% vs 67%, P < .001). Overall sensitivity and specificity for luminal stenosis (> or =50%) were 69% and 82% (group 1) and 76% and 92% (group 2) (P > .05 and P < .001, respectively). Baseline heart rate-adjusted ECG triggering improves image quality at coronary artery CT angiography for detection of coronary artery disease.

Adult↗
PubMed2004

Relation of degree of physical activity to coronary artery calcium score in asymptomatic individuals with multiple metabolic risk factors.

Lack of physical activity (PA) increases risk of coronary heart disease. Metabolic risk factors increase the risk of coronary heart disease and development of advanced coronary artery calcium (CAC). We hypothesized that, in a population with multiple metabolic risk factors (> or =2), the degree of PA would be inversely associated with the degree and prevalence of CAC. After excluding subjects who had known diabetes and coronary heart disease, we studied 779 asymptomatic patients referred for electron beam tomography. All patients had > or =2 of the following metabolic risk factors: blood pressure > 130/85 mm Hg, serum triglycerides >150 mg/dl, serum high-density lipoprotein < 40 and < 50 mg/dl in men and women, respectively, and body mass index >30 kg/m(2). Advanced CAC was defined as a calcium score >75th percentile based on gender and age. In the study, 37% patients were sedentary, 26% engaged in moderate-duration (< 30 minutes 1 to 2 times/week) PA, and 37% engaged in long-duration (> or =30 minutes > or =3 times/week) PA. The median CAC scores were 24 (sedentary), 18 (moderate PA), and 11 (long-duration PA; p <0.002). Advanced CAC was prevalent in 26% of sedentary patients, 24% of patients who performed moderate PA, and 16% of patients who engaged in long-duration PA (p <0.05). On logistic regression analysis, long-duration PA had an independent inverse association with advanced CAC. Thus, asymptomatic patients who have > or =2 metabolic risk factors and who regularly engage in long-duration PA have a lower prevalence of CAC than do those who are sedentary or participate in moderate-duration PA.

Calcinosis↗
PubMed2004

Coronary artery calcium volume scores on electron beam tomography in 12,936 asymptomatic adults.

We developed age- and gender-specific normative tables of calcium volume scores by using data from 12,936 asymptomatic patients who underwent electron beam tomographic scanning and compared the volume with the Agatston scores obtained in the same subjects. The 2 scores increased as the number of atherosclerotic risk factors increased. The volume scores were statistically smaller than the Agatston scores at the upper quartile level.

Adult↗
PubMed2004

Methodology for improved detection of coronary stenoses with computed tomographic angiography.

BACKGROUND: Noninvasive angiography is a promising technique for visualization of the coronary lumen; however, current methodologies lead to limited accuracy. We assessed the accuracy of electron beam computed tomographic angiography (EBA) for detection of coronary stenoses, using improved triggering techniques and thinner slice collimation. METHODS: Eighty-six patients with suspected coronary disease were studied with EBA and conventional invasive coronary angiography. Electrocardiographic triggering was performed at a fixed time in end systole to reduce cardiac motion. Thin (1.5 mm) slices were obtained with 1.5 mm table incrementation. In axial (2-dimensional) EBA images and 3-dimensional reconstructions, all coronary arteries and side branches with a diameter of >or=1.5 mm were assessed for the presence of stenoses with >50% diameter reduction. Both EBA and invasive angiographic images were assessed in a blinded manner. RESULTS: In comparison to invasive coronary angiography, EBA correctly classified 49 of 53 patients (92%) as having at least 1 coronary stenosis. Overall, 103 stenoses with >50% diameter reduction were present, and 93 of these lesions were correctly detected by EBA (sensitivity 90%, specificity 93%, positive predictive value 84%, and negative predictive value 96%). Only 5% of vessels could not be assessed, predominantly due to significant calcification. CONCLUSIONS: Thinner slice collimation and end-systolic electrocardiographic triggering improves accuracy and assessment of coronary EBA for the detection of obstructive coronary artery disease, making this study clinically useful in the evaluation of obstructive coronary artery disease.

Coronary Angiography↗
PubMed2004

Underlying risk factors incrementally add to the standard risk estimate in detecting subclinical atherosclerosis in low- and intermediate-risk middle-aged asymptomatic individuals.

BACKGROUND: Traditional risk factors predict the 10-year risk of developing coronary heart disease (CHD). Underlying risk factors like physical inactivity, obesity (BMI >30 kg/m2), and family history of premature CHD are independently associated with CHD. High burden of coronary artery calcification (CAC) on electron beam tomography (EBT) is a CHD risk equivalent. GOALS: To determine the association between CAC and traditional risk assessment and whether the presence of added underlying risk factors is associated with advanced CAC in low- and intermediate-risk individuals. METHODS: After excluding patients with CHD, we studied 8549 asymptomatic individuals referred for EBT for cardiac risk assessment. Traditional myocardial infarction risk score was estimated according to Framingham criteria, and individuals were divided into 3 groups: low-risk (< or =9% MI risk over the next 10 years), intermediate-risk (10%-20% risk), and high-risk (>20 % risk). Advanced CAC was defined as a calcium score > or =75th percentile based on sex and age. RESULTS: The prevalence of advanced CAC was 20% in low-risk, 27% in intermediate-risk, and 31% in high-risk individuals (P < .001). Underlying risk factors were incrementally associated with advanced CAC in low- and intermediate-risk individuals (P < .001). A receiver operating characteristic curve analysis revealed that addition of underlying risk factors to traditional risk assessment increased the area under the curve significantly from 0.56 to 0.62 (P < .001). CONCLUSION: A substantial proportion of low- and intermediate-risk individuals have advanced CAC. Adding family history, obesity, and physical inactivity to traditional risk assessment improves prediction of advanced CAC, which may lead these individuals to be treated more aggressively at an earlier age.

Calcinosis↗
PubMed2004

Long-term patency of coronary grafts with endoscopically harvested saphenous veins determined by contrast-enhanced electron beam computed tomography.

OBJECTIVES: We determined the long-term patency rates of coronary artery grafts with endoscopically harvested saphenous veins. METHODS: Patency rates were established in 51 patients with 130 distal saphenous vein grafts using contrast-enhanced electron beam computed tomography at 3.74 +/- 0.65 years after coronary artery bypass grafting. A similar group of 50 patients with 131 distal grafts were studied prospectively using the same methodology at 0.7 +/- 0.19 years after coronary artery bypass grafting. RESULTS: The overall patency rates were 95.4% in the retrospective group and 95.3% in the prospective group. Sequential grafts tended to have a patency advantage over independent grafts. CONCLUSIONS: These data compare favorably with reported patency rates for traditionally harvested saphenous veins. Endoscopic saphenous vein harvesting, in addition to previous favorable reports on pain, complications, and costs, is now shown to provide comparable or better patency rates in comparison with traditionally harvested veins.

Aged↗
PubMed2004

Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study.

BACKGROUND: Aged Garlic Extract (AGE) reduces multiple cardiovascular risk factors, including blood pressure, cholesterol, platelet aggregation and adhesion, while stimulating nitric oxide generation in endothelial cells. However, no study has evaluated the ability of AGE to inhibit vascular calcification, a marker of plaque formation in human coronary arteries. OBJECTIVE: To assess the efficacy of Aged Garlic Extract (AGE) on changing the rate of atherosclerosis progression as compared to placebo. DESIGN: A placebo-controlled, double-blind, randomized pilot study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE as compared to placebo. Twenty-three patients were enrolled, and 19 patients completed the study protocol. AGE 4 ml or the equivalent amount of placebo was given to subjects. Duration of the study was 1 year. S-allylcysteine (SAC), one of the active compound of AGE, was measured in the blood as a compliance marker. RESULTS: The mean change of the calcium score (volumetric method) for the AGE group (n = 9) was 7.5 +/- 9.4% over 1 year. The placebo group (n = 10) demonstrated an average increase in calcium scores of 22.2 +/- 18.5%, significantly greater than the treated cohort (P = 0.046). There were no significant differences in individual cholesterol parameters or C reactive protein between the groups. In patients randomized to AGE, there was a nonsignificant trend for improving cholesterol/high-density lipoprotein ratio (P = 0.07) and homocysteine level (P = 0.08). CONCLUSIONS: This small pilot study indicates the potential ability of AGE to inhibit the rate of progression of coronary calcification, as compared to placebo over 1 year. Should these findings be extended and confirmed in larger studies, garlic may prove useful for patients who are at high risk of future cardiovascular events.

Arteriosclerosis↗
PubMed2004

Improved accuracy of noninvasive electron beam coronary angiography.

OBJECTIVES: We investigated the effect of electrocardiographic (ECG) triggering on the accuracy of coronary electron-beam angiography (EBA) as compared with invasive angiography. METHODS: One hundred thirty-three patients with suspected coronary disease were studied with intravenous coronary EBA and conventional coronary angiography. Patients were divided into 2 groups based upon ECG triggering on the EBA study. Patients were divided into 2 groups based upon different ECG triggering used: 80% R-R interval trigger method (group 1, n = 53) and end-systolic triggering (group 2, n = 80). End-systolic ECG triggering, which started at the end of the T wave in each study, was based on baseline heart rate. RESULTS: Overall sensitivity to detect a > or = 50% luminal stenosis was 69% in group 1 and 91% in group 2 (P = 0.002); specificity was 82% and 94% in group 1 and group 2, respectively (P < 0.001). Using newer triggering techniques (group 2) with EBA, the sensitivity, specificity, and accuracy for patients with disease of the left main coronary artery or 3 vessel disease was 100%, 94%, and 98%, respectively. Nonassessability of coronary segments on 3D-EBA images was reduced from 35% in group 1 to 9% in group 2 patients (P < 0.001). The number of motion-free coronary images increased from 67% to 95% from group 1 to group 2 (P < 0.0001). CONCLUSION: End-systolic ECG triggering improves accuracy, image quality, and assessability of segments of coronary EBA for the detection of angiographic coronary artery disease.

Algorithms↗
PubMed2004

Thebesian valve imaging with electron beam CT angiography: implications for resynchronization therapy.

We report visualization of a prominent coronary sinus os valve (Thebesian valve), by electron beam computed tomographic angiography, which impeded an endocardial approach to left ventricular pacing. Resynchronization therapy was therefore performed with an epicardial approach to left ventricular lead placement. Electron beam computed tomographic angiography can provide detailed information for coronary sinus instrumentation, including anomalies potentially affecting the approach to resynchronization therapy.

Aged↗
PubMed2004

Thebesian valve imaging with electron beam CT angiography: implications for resynchronization therapy.

We report visualization of a prominent coronary sinus os valve (Thebesian valve), by electron beam computed tomographic angiography, which impeded an endocardial approach to left ventricular pacing. Resynchronization therapy was therefore performed with an epicardial approach to left ventricular lead placement. Electron beam computed tomographic angiography can provide detailed information for coronary sinus instrumentation, including anomalies potentially affecting the approach to resynchronization therapy.

Aged↗