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Biomedical subjects

M Zieger

Publications and source records attributed to M Zieger.

At least 55 records · Page 3Linked to original sources

[Value of angle measurements in hip sonography. Methodological and technical analysis].

The Graf classification of sonographic hip-studies is based upon angle-measurements. 167 patients have been examined and evaluated in a double-blind study of the reproducibility of these measurements and the resulting classification. The resulting ranges for the different types were compared with the values given by Graf. The influence of the investigator, the interpreter and of the chosen section plane were analysed and compared with the difference in classifying based upon visual impression. The global impression of the operator proves to be the most reliable basis for interpreting the ultrasound study (variation of 6%), while the measured angle beta (+/- 35% deviation) seems not to be as useful.

Child, Preschool↗

[Spinal sonography in childhood. Indications and value in abnormalities and space-occupying lesions].

Conditions, examination technique, and sonographic anatomy of the spinal canal are presented. The sonographical appearance of various kinds of dysraphism and their differentiation, of malformations at the cranio-cervical junction and of mass lesions is demonstrated and illustrated. Based on our preliminary experience spinal sonography appears to be useful as first imaging device for the differentiation of complex malformations, and as screening method for occult dysraphism. In case of mass lesions spinal sonography is suitable to diagnose and follow up disease although additional imaging procedures are currently needed for the confirmation of the diagnosis.

Adolescent↗

[Differential diagnosis of posttraumatic pulmonary infiltrates].

The differential diagnostic value of radio-morphological criteria as well as the prognostic fate of pulmonary infiltrates was studied in 377 patients presenting with major traumatic infiltrates in the thorax. We found that neither the character of the infiltrates (alveolar/interstitial) nor their morphology (homogeneous/inhomogeneous, dense/dispersed) were suitable for differentiation owing to extensive overlapping. The localization of infiltration, otherwise a good diagnostic indicator, provided little reliable information either. Conversely, the time course of the infiltrates, especially the time of their first visualization, turned out to be the only criterion usable for differentiation. Patients studied immediately after or within hours of an accident exhibited contusion and aspiration infiltrates, with a delay of 1-2 days the infiltrates were mostly caused by fat embolism and ARDS, while pneumonic infiltrates appeared after at least 2 days. The course of the infiltrates further permits certain diagnostic conclusions, but it is of little help in establishing the primary diagnosis and may be usable for corrections at best. The relatively high specificity of the criterion "first appearance of infiltrates" may be reduced by the coincidence of several lesions or ensuing complications. In retrospect, it seems that a reliable radiological differential diagnosis of posttraumatic infiltrates is not possible, but satisfactory results can be achieved if specific X-ray criteria are viewed against an extensive clinical back-ground.

Adult↗

Vascular resistance, metabolism and EEG within cerebral grey and white matter during hypoxia in neonatal piglets.

To study unsolved problems of the causal chain of neonatal hypoxic brain damage in 31 hypoxic newborn non-anesthetized piglets cerebro-vascular, metabolic and EEG reactions were investigated (FiO2: 0.06-0.10, 1 h). Only in artificially ventilated newborn piglets this acute hypoxic hypoxia provoked a vital decompensation by critical depression of mean arterial blood pressure (less than or equal to 4.67 kPa [35 mmHg]) and/or a critical increase of vascular resistance (Rc) in the cerebral white matter (greater than 50%). Spontaneously breathing piglets survived always showing hyperventilation, higher pHa and an increase of cerebral O2-consumption in cerebral grey matter, partly also in white matter. This critical increase of Rc was related to a critical decrease of O2-consumption in the white matter and an insufficient decrease of Rc of the grey matter. The observed strong metabolic and hemodynamic differences between these two brain compartments can explain the evaluated special morphological vulnerability of cerebral white matter in ventilated animals.

Animals↗

[Importance of digital subtraction angiography in the control of dialysis shunts].

The methods, indications and results of imaging haemodialysis access devices, using DSA techniques, are presented, based on 34 examinations. The advantages of this technique with respect to radiation exposure, dynamic registration and dose of contrast medium are compared with conventional film-screen techniques. Case reports illustrate the result and clinical value. DSA is recommended as the method of choice for the common indications for imaging haemodialysis access devices.

Adult↗

[Computed tomographic diagnosis of renal tumors without using contrast media].

The question whether contrast medium is necessary for diagnosis of renal tumour in CT is studied on the basis of 80 histologically proven cases of hypernephroma. More than 97% of the tumours were diagnosed on plain scan. The presence of structural inhomogeneities was decisive for recognising tumours 2 cm and larger without the use of c.m. In disagreement with current opinion injection of c.m. is not necessary for exclusion of hypernephroma. Injection of c.m. is useful however for differentiating between physiological variations and tumours less than 3 cm in size, and for diagnosis of tumour thrombosis of the renal vein.

Adenocarcinoma↗

[Innominate grooves. A discussion].

Innominate grooves are delicate, inconstant speculations on the colonic margin which may be seen on barium enemas; their origin and significance are matters for discussion. Three hundred and fifty-three double contrast enemas (divided into four groups, depending on the techniques uses) were studied in respect of the presence, localisation and circumstances under which innominate grooves could be seen. The results showed that the incidence of grooves depended on the technique used and varied between 91% and 3%. The most common localisations were the descending and sigmoid colon and in the transverse colon, near the hepatic flexure. The grooves could be seen only towards the end of the examination. It follows that innominate grooves are a normal phenomenon in a healthy mucosa, which can be recognised under optimal circumstances. It is probably due to visualisation of the relief pattern of the mucosa, the delicate folds being particularly noticeable in relation to lymph follicles. Innominate grooves should not be misinterpreted as abnormal findings, but must be distinguished from somewhat similar changes in the colon due to inflammatory disease.

Colon↗

[Determination of colloid concentration in static liver scintigrams - clinical applications].

This prospective study of a large number of patients demonstrates the clinical possibilities of impulse densitometric evaluation of colloid concentration in static liver scintigraphy. In addition to interobserver variation and intrapersonal reproducibility the demarcation between normal and cirrhotic livers and the relationship of impulse densitometry to clinical and blood parameters are described. Case studies show the potential advantages for routine diagnostics.

Absorptiometry, Photon↗

[Normal renal variations as a cause of sonographically suspect tumors].

106 cases of 470 computed tomographic studies of suspected renal tumors were referred to us because a tumor was expected by ultrasound examination. 67 suspected renal tumors proved to be physiological variations, in 39 cases tumor suspicion was confirmed by computed tomography. Since ultrasound findings frequently seem to be false positive, criteria for the diagnosis of renal tumors were reviewed. Our experience is that the combination of inhomogeneity in echo pattern, irregularity of the outer contour and/or the inner parenchymal border seems to be relevant for ultrasound diagnosis of renal tumors whereas isolated widening of parenchyma does not seem to be suspicious by itself.

Diagnostic Errors↗

[Diagnosis of occult skeletal metastasis: alkaline phosphatase versus skeletal scintigraphy].

In this study the value of alkaline phosphatase activity was compared with the bone scintigram in detection of clinically occult bony metastasis amongst a group of 400 cases histories of cancer patients. For bone scanning a sensitivity of 96% and a specificity of 94% were detected, among the unsuspected scans, only 1% bony metastasis was demonstrated. For the levels of alkaline phosphatase a sensitivity of 74% and a sspecificity of 85% were demonstrated, with normal levels only in 4% bony metastasis were detected. The true positive elevated levels of alkaline phosphatase in 43% of cases normalised within two months. It is implicated that controlling tumor patients by bone scanning may be substituted by short term determination of the level of alkaline phosphatase in the practice of general practitioners.

Alkaline Phosphatase↗

[Diagnostic significance of the colloid concentration in the static liver scintigram].

The count density in the right liver lobe is presented as a parameter for the recognition of diffuse parenchymal diseases of the liver by means of static colloidal scanning. Sensitivity, specificity, and accuracy (87-100%) in separating normal from parenchymal damage and cirrhosis are comparable to the results of dynamic sequence scanning. Since this parameter is easy to be measured it is proposed for clinical application.

Chronic Disease↗