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Biomedical subjects

M Zerbib

Publications and source records attributed to M Zerbib.

At least 163 records · Page 9Linked to original sources
PubMed1983

[Prevention of bacterial grafts on revascularization of the arteries of the leg. Apropos of 18 infections in 1000 surgically treated cases].

The incidence of vascular and prosthetic infections was compared during two successive periods, each involving approximately 500 surgical acts, a strict protocol of infection prophylaxis being applied during the second period: infection was reduced from 2.7 to 1.5 p. cent (2.3 to 0.5 p. cent after aorto-ilio-femoral grafts). Failure to respond to treatment during the second period occurred under two circumstances: when prophylaxis was insufficient to cover emergency procedures, and when antibiotic therapy was directed against staphylococci only, resulting in persistence of a high level of infections due to Gram-negative bacilli. Analysis of different epidemiological factors, including the germs, the patient, the treating team, and the prosthesis, led to the adoption of numerous specific measures. Their respect implies collective awareness, assisted by analysis of weekly complications and annual results with the involvement of the total team. Prophylactic antibiotic therapy should be of short duration, the antibiotics being selected in reference to the sensitivity of the germs included in the hospital statistics, and of the antibiotic policy which reserves recently developed molecules for curative purposes.

Aged↗
PubMed1982

[Splenic abscess. 3 cases (author's transl)].

The authors report three cases of splenic abscess. The condition developed twice during a salmonella infection associated in one case with sickle cell disease. In two patients, the spleen was the site of a suppurated infarction. One patient died shortly after operation. Study of the 79 cases of splenic abscess treated surgically published since 1960 reveals a mortality of 16%. This rare condition is seen essentially during typhoid and septicaemias (endocarditis). Such pathology in also now seen in drug addicts. The diagnosis and, hence, the prognosis should be improved by the use of echography which seems to be the most reliable investigation before peritonitis by rupture which remains a complication associated with a heavy mortality.

Abscess↗
PubMedDate not supplied

[Intermittent hormone therapy for prostate cancer].

Intermittent hormone therapy in prostate cancer consists in disrupting treatment after the nadir PSA has been reached, and reinitiating treatment when the PSA increases over a certain threshold. Theoretical advantages of intermittent hormone therapy are to delay the occurrence of hormone-independence and to decrease treatment-related side effects. Some phase II trials have demonstrated the feasibility of intermittent hormone therapy. The percent time without treatment varies between 40 and 50%. Oncologic results of intermittent hormone therapy are, at least, equivalent to those of continuous therapy. Moreover, the side effects of treatment are decreased and the quality of life is improved during off treatment phases. Due to the lack of comparative studies, the superiority of intermittent upon continuous treatment has not been established at long-term follow-up. Prospective comparative trials are ongoing; they will determine the true benefit of intermittent hormone therapy in prostate cancer.

Antineoplastic Agents↗
PubMedDate not supplied

[Advances in surgical techniques and results of radical cystectomies for bladder cancer. 106 patients].

AIM OF THE STUDY: Retrospective analysis of result of radical cystectomy at Cochin Hospital. PATIENTS AND METHODS: We report the results of a 106 patients series treated by radical cystectomy for bladder carcinoma after a 5-year period follow-up. RESULTS: The extent of the tumour invasion according to pathological analysis was: pT1 or less: 26%, pT2 and pT3a: 33%, pT3b and over: 41%. Morbidity rate was 19% with a 7.5% reintervention rate. Long term complication rate was 31%, concerning essentially ureteral stenosis. A local recurrence or distant metastasis occurred in 35% of patients. Local recurrence rate was 10.7%. Cancer specific survival rates were 88%, 81% and 42% for pT1, pT2-pT3a, and pT3b patients respectively. CONCLUSION: The present results confirm that radical cystectomy is the most effective curative treatment for invasive bladder carcinoma.

Adult↗
PubMedDate not supplied

[The treatment of patients with ureteral calculi by ureteroscopy and intracorporeal lithotripsy].

Ureteroscopy with endocorporeal urinary stone lithotripsy (EUSL) implies an "in situ" stone fragmentation including or not a basket extraction of the fragments. EUSL needs three conditions: ureteronephroscopy (antegrade or retrograde), sources of energy (ultrasonic, electrohydraulic, laser), extraction devices (basket, grasping forceps). The paper reports the data on 120 ureteral stones treated by ureteroscopy and laser lithotripsy with an overall effect of 84%.

Endoscopes↗
PubMedDate not supplied

[Penile prostheses].

Explore the source record for details and available documents.

Erectile Dysfunction↗
PubMedDate not supplied

[Evaluation of the number of patients likely to require surgical treatment of hepatic metastases. Based on a series of 180 colorectal cancers].

The spontaneous prognosis of patients with hepatic metastases from colo-rectal cancer is poor in the short term: less than 10 p. cent will be alive after 2 years. Over recent years, several teams have obtained encouraging results after surgical resection of hepatic metastases. The aim of the present study was to evaluate the number of patients likely to require resection of hepatic metastases in a serie of 180 cases of colo-rectal cancer. 57 patients (30 p. cent) already had hepatic metastases at the time of the gastro-intestinal resection and only 3 underwent a simultaneous metastasectomy. In the other cases, the extent of the disease or the general condition of the patients contra-indicated a 2-stage resection. Among the 126 patients free of metastases at the time of the operation, 40 p. cent would have been excluded from hepatic resection in the event of secondary development of metastases because of the general clinical state. 75 patients were suitable for post-operative surveillance of hepatic metastases. We calculated that 20 of them might develop a hepatic metastasis without local recurrence of the colo-rectal cancer in the 2 years following the colonic resection, although of course we were unable to predict the type of metastasis or its accessibility to surgery. These figures may be useful as a guide to the development of a surveillance strategy.

Aged↗
PubMedDate not supplied

[Voluminous exogastric myoid tumor. Contribution of echotomography and x-ray computed tomography].

We described a case of voluminous exogastric leiomyoblastoma revealed by abdominal pain and clinical mass. Ultrasonography showed a mixed mass, with both solid and liquid components, without determining specifically the organ of origin. CT body examination showed an intense hypervascularization, associated with cystic components. Laparotomy with tumor excision was done without any metastases. Such US and CT aspects can lead to the exact diagnostic, if they prove the gastric origin of the mass. Otherwise, the discussion is between pancreatic or epiploic tumors.

Abdominal Neoplasms↗