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Biomedical subjects

M Wysocki

Publications and source records attributed to M Wysocki.

At least 127 records · Page 7Linked to original sources
PubMed1986

Changes in lung function determined longitudinally compared with decline assessed cross-sectionally. The Cracow Study.

Longitudinal annual changes in lung function (FEV1) with cross-sectional estimates have been compared in the sample of Cracow inhabitants who underwent epidemiological follow-up on chronic nonspecific chest diseases. The annual rate of FEV1 decline was faster in men than in women. Among male smokers the FEV1 decline rate was 30% greater, while in women smokers 9% faster than in non-smokers. The cross-sectional estimates for annual changes differed in both surveys carried out in the interval of 13 years and were not very much consistent with the average longitudinal annual decline observed in the sample. However, the prediction of annual decline across the age groups showed large inconsistencies. They resulted from the curvilinear pattern in lung function decline over the age groups. It was found that the lung function in the elderly appeared to be more homogeneous and the acceleration of decline rates slowed down. There is some evidence that the flattening of the decline curve among elderly might have been influenced by the selection bias.

Adult↗
PubMed1986

The relation of thirteen-year mortality to ventilatory impairment and other respiratory symptoms: the Cracow Study.

The relation of mortality to ventilatory function and some respiratory symptoms detected during interview has been studied in 3047 men and women followed-up for 13 years. The analysis was performed for all natural causes of death, and separately for deaths due to circulatory diseases and neoplasms. The results confirm the strong predictive power of ventilatory impairment for overall and circulatory mortality, even after adjustment for age, cigarette smoking and other factors in logistic regression models. The risk of cancer death in men increased with decrease of FEV1. However, chronic cough, mucus hypersecretion or asthmatic syndrome were not related to subsequent mortality. A strong predictor of overall and circulatory 'mortality' in men was also self-assessed health status. This was independent of other factors.

Adult↗
PubMed1986

Increase in plasma atrial natriuretic peptides during acute volume expansion in hypertensive man.

A new hormonal system originating from cardiac atria has recently been discovered. These peptide hormones have important functions in the regulation of blood volume and fluid homeostasis. We have measured plasma concentrations of atrial natriuretic peptides (ANP) in two patients during acute volume expansion. ANP concentrations increased in relation to an increase in right atrial pressure, and significant diuresis/natriuresis was observed. We conclude that hormonal as well as neuronal mechanisms are activated by acute volume loading in man.

Atenolol↗
PubMed1986

Factors associated with the change in ventilatory function and the development of chronic obstructive pulmonary disease in a 13-year follow-up of the Cracow Study. Risk of chronic obstructive pulmonary disease.

In a longitudinal, epidemiologic study, we investigated the relation of a number of factors to the loss of ventilatory lung function over time and to the incidence of chronic obstructive pulmonary disease (COPD). Data on 759 men and 1,065 women 19 to 70 yr of age examined twice during a 13-yr period were analyzed. The decline rate in FEV1 was related to age and was greater in persons with lower FEV1 values and in taller persons. The clear relation to smoking was confirmed. Occupational exposure to dusts in men and to variable temperatures in women significantly increased the FEV1 decline rate. In men in blood group A, the loss of FEV1 was smaller than in men in the other blood groups. In women who had had 4 or more children, we observed a faster decline in FEV1. In the analysis of COPD incidence, we confirmed that age, baseline FEV1 value, and, in men, smoking habit are the most important predictors of disease. Among women, also, attacks of breathlessness were demonstrated to increase disease risk twofold (p less than 0.10), even after adjustment for other factors in the logistic regression model. We estimated the index of risk for COPD and predicted 63% of male and 67% of female cases in the top 20% of risk distribution.

Adult↗
PubMed1986

Concentration of tumour markers CEA, AFP, alpha and beta subunits of hCG in cerebrospinal fluid in children with inflammatory diseases of the central nervous system.

Carcinoembryonic antigen (CEA), alphafetoprotein (AFP) and alpha-beta subunits of human chorionic gonadotropin (hCG) were determined by radio-immunoassay in CSF of 83 children presenting some central nervous disease and compared to the corresponding values obtained in 88 children without neuroinfection. CEA and alpha hCG were absent in the CSF of children without neuroinfection. CEA and alpha hCG levels in CSF higher than 0.0 ng/ml were regarded as elevated. In patients with inflammatory process of CNS, CEA values were positive in 9% (maximum 8.0 ng/ml) and alpha hCG in 4% (maximum 5.0 ng/ml). AFP in CSF ranged from 15.0 to 49.0 ng/ml in children without neuroinfection, and from 0.0 to 100.0 ng/ml in patients with inflammatory diseases of the CNS. As a normal upper limit of AFP in CSF, 53.2 ng/ml is suggested; in 31% of the patients with inflammatory diseases of CNS the AFP level was elevated. The normal upper limit of beta hCG concentration in CSF was regarded as 0.4 ng/ml; in 12% of the patients with viral meningoencephalitis the beta hCG level in CSF was slightly elevated, it ranged from 0.5 to 3.0 ng/ml.

Adolescent↗
PubMed1985

Longitudinal monitoring of changes in individual smoking habit over 13-year period among adults.

The purpose of the longitudinal monitoring of smoking habits among adults was to define demographic and social characteristics which may contribute to the persistence of smoking and to evaluate the effectiveness of the preventive programs undertaken by the mass media. The data has been collected during the follow-up epidemiological study on chronic nonspecific chest diseases in Cracow, Poland. In total the material covered a sample of 2965 persons who were interviewed three times over 1968-81 period. In the analysis the prevalence rates, incidence and cessation rates have been taken into consideration. The results obtained in the study confirm the decline in the prevalence of smoking habit among men but among females increased substantially in the younger birth cohorts. Incidence rate of smoking in females was higher than in men but cessation rates were very similar. The striking was the fact that the prevalence of smokers in the youngest age group in university graduates was about three times higher in women than in men. The results call for more knowledge about the psychosocial factors that may contribute to the initiation of smoking and more effective strategies applied to deter the onset of smoking.

Adult↗