Biomedical subjects
M Williams
Publications and source records attributed to M Williams.
Give me a desk job. I used to be a nurse!
Explore the source record for details and available documents.
When all your credit runs out.
Explore the source record for details and available documents.
Sleepless nights.
Explore the source record for details and available documents.
Clinical regrading hazards.
Explore the source record for details and available documents.
Employment: secrets from the agency.
Explore the source record for details and available documents.
Professionalism: one in the eye for care.
Explore the source record for details and available documents.
One minute wisdom. All you need to know about CS gas.
Explore the source record for details and available documents.
A plan for earthquake-proofing your hospital. California Association of Hospitals and Health Systems.
Explore the source record for details and available documents.
Food intolerance: nutritional consequences of adverse reactions to food.
Explore the source record for details and available documents.
Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study.
To establish the maximum tolerated dosage (MTD), the dose-limiting toxicities (DLTs), and pharmacokinetic parameters of CI-980, a novel tubulin binder, in children with solid tumors refractory to standard therapy. Patients 21 years of age or younger with adequate nutritional, hematopoietic, renal, and hepatic function were eligible. The patient must not have been pregnant. Patients with brain tumors were not eligible for any dosage level until it was demonstrated the level did not produce DLT in patients with extracranial solid tumors. The starting dosage level was 3.5 mg/m2/day, for 3 days, administered as a continuous intravenous infusion (80% of the adult MTD). If a dosage level was associated with dose-limiting myelotoxicity, growth factors were to be added. Thirty-three patients received CI-980. Twenty-four had solid tumor; 9 had brain tumor. The MTD achieved without granulocyte colony stimulating factor (G-CSF) was 3.5 mg/m2/day (DLT: neutropenia) and with G-CSF, it was as follows: patients with brain tumor, 4.2 mg/m2/day (DLT: myelosupression); and patients with solid tumor, 5 mg/m2/day (DLT: cortical toxicity). Several responses were seen, most notably prolonged stable disease in two of five patients with medulloblastoma. Pharmacokinetic data showed a mean steady state level of 1.74 ng/mL for two patients treated with the 5 mg/m2/day regimen, with rapid decay after the termination of the infusion. CI-980 showed preliminary evidence of activity in recurrent pediatric malignancies, with tolerable, reversible toxicities.
Improving advocacy through new technology.
Explore the source record for details and available documents.
Nurse prescribing. An extension of responsibility.
Explore the source record for details and available documents.
The influence of eccentric contractions and stretch on alpha motoneuron excitability in normal subjects and subjects with spasticity.
Application of eccentric contractions and muscle stretch are clinically effective in reducing spasticity and increasing ROM (7). This may be explained by a change in the excitability of motoneurons supplying the spastic muscle. Excitability of motoneurons can be indirectly assessed using the H-reflex. Experiments were performed on 20 normal subjects and 17 subjects with spasticity resulting from neurological disorder. Subjects were seated in a secure position and the ankle joint was moved from 30 degrees plantarflexion to 20 degrees dorsiflexion at a velocity of 30 degrees/sec. Sixty eccentric contractions of the triceps surae muscle were performed using a Kin-Com dynamometer (Chattanooga Corp, Tennessee). Two protocols were used: (1) eccentric contractions only, and (2) eccentric contractions with a 5s stretch of the relaxed triceps surae after each contraction. Two sets of 10 H-reflexes were collected from the soleus muscle before (trial 1 & 2) and after (trial 3 & 4) eccentric and eccentric + stretch protocols. The mean peak to peak H-reflex amplitude was calculated for each trial and compared using ANOVA. Eccentric contractions resulted in a significant and maintained increase in the H-reflex in neurological compared to normal subjects (P < 0.05). Eccentric contractions in subjects with spasticity resulted in an increase in motoneuron excitability which may assist in corticospinal activation of motoneurons during voluntary movement. The eccentric + stretch protocol, resulted in a decrease in the mean amplitude of H-reflexes in neurological subjects, however, this was not significant. The application of a stretch following eccentric contractions decreased motoneuron excitability and may thus be beneficial to decrease spasticity whilst strengthening muscle.
Oncology Nursing Society Workforce Survey. Part I: Perceptions of the nursing workforce environment and adequacy of nurse staffing in outpatient and inpatient oncology settings.
Explore the source record for details and available documents.
Health visiting in a custodial environment.
Explore the source record for details and available documents.
Urbanization and economic development.
"This paper seeks to contribute to the discussion on the relationship between the levels of urbanization, levels of economic development and the pattern of economic activities." The focus is on the situation in developing countries, and the data are from published World Bank sources. Data on per capita income are used to stratify countries into development levels. The study includes data on centrally planned economies and on African countries.