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Biomedical subjects

M Wheeler

Publications and source records attributed to M Wheeler.

At least 91 records · Page 5Linked to original sources
PubMed1982

Agaridoxin: a fungal catecholamine which acts as an alpha 1 agonist of mammalian hypothalamic adenylate cyclase.

Agaridoxin, a catecholamine isolated from mushrooms, and 4 synthetic analogues cause activation of adenylate cyclase in the presence of guanylyl imidodiphosphate (Gpp(NH)p) in membrane particles prepared from rat hypothalamus. These compounds also activate adenylate cyclase preparations from rat kidney, liver and cerebral cortex. In the presence of tyrosinase, these compounds are readily oxidized to quinones which lack agonist activity. Studies with selective adrenergic blockers suggest that agaridoxin acts at an alpha 1-type receptor. Agaridoxin-mediated adenylate cyclase stimulation is most effectively antagonized by WB-4101 and phenoxybenzamine, while propranolol and yohimbine are without inhibitory effect. Agaridoxin and the alpha 1 agonist methoxamine inhibited the binding of [3H]WB-4101 in rat hypothalamic and cerebral cortical membranes. The values of Ki for both compounds are lower than that of norepinephrine. The agaridoxin analogue, 4-aminocatechol hydrochloride, is a more effective and potent adenylate cyclase activator than agaridoxin or methoxamine.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1981

Computerized triage of pediatric patients: automated triage algorithms.

Pediatric triage algorithms which were prospectively and retrospectively validated in a pediatric acute care facility serve as the basis for the development of a simplified pediatric triage checklist. This checklist is used by minimally trained nonprofessionals to assign safely the care urgency categories of the chief complaints of pediatric "walk-in" patients. This article describes the background of the pediatric triage checklist and its adaptation to a computerized triage system. This system not only allows for safe triage, but also creates a mechanism for rapid, organized retrieval of data from individual and group patient triage encounters that is useful for the study and planning of health care delivery.

Child↗
PubMed1980

Sex hormone changes in male epileptics.

Mean plasma levels of LH, FSH, PRL, and sex-hormone binding globulin (SHBG) were raised in twenty-seven epileptics on anticonvulsants compared with age matched controls. Sexual activity appeared to be reduced. Anticonvulsant therapy results in raised SHBG levels which may be associated with a lowered free testosterone level as indicated by raised LH levels and lowered sexual activity.

Adult↗
PubMed1979

Bromocriptine suppression of TRH-stimulated prolactin and thyrotrophin release and accompanying inhibition of bromocriptine induced growth hormone release by TRH in normal man.

Six normal fasting males received on four separate occasions in random order (1) a placebo tablet followed 60 min later by 200 microgram of TRH intravenously (2) bromocriptine 2.5 mg orally followed by TRH intravenously (3) bromocriptine 2.5 mg orally followed by a placebo injection and (4) placebo tablet followed by placebo injection. Plasma prolactin and TSH responses to TRH were decreased following bromocriptine pretreatment. The rise of plasma growth hormone after bromocriptine was inhibited by TRH. The rise in plasma FSH seen after TRH injection was not influenced by bromocriptine pretreatment. Circulating LH and insulin concentrations were unaffected by any drug administration. These results suggest a dopaminergic influence on prolactin and TSH release in normal men, an inhibitory effect of TRH on bromocriptine stimulated growth hormone secretion, and no dopaminergic modulation of basal insulin secretion.

Adult↗
PubMed1979

Buying and food preparation patterns of ghetto blacks and Hispanics in Brooklyn.

Differences in food buying and food preparation practices of blacks and Hispanics in the Bedford-Stuyvesant section of Brooklyn, New York, are analyzed. There were significant variations related to ethnicity, but few differences resulting from the mothers' age and education. The two groups appeared to have many compatible practices which could be improved by the same educational programs, if they were taught in both English and Spanish.

Adolescent↗
PubMed1979

Nutritive intake of black and Hispanic mothers in a Brooklyn ghetto.

The nutritional status of black and Hispanic mothers living in the Bedford-Stuyvesant section of Brooklyn, New York, was evaluated, using three-day dietary recall, a questionnaire on food buying and preparation techniques, and anthropometric measurements. Mean nutrient intake of both groups was considerably lower than the 1974 Recommended Dietary Allowances for all nutrients studied except protein, ascorbic acid, and phosphorus. Body weight and triceps skinfold values for both groups were higher than standard, suggesting obesity. Reasons for these findings are discussed with emphasis on the importance of nutrition education.

Adolescent↗
PubMed1976

Osteoporosis.

Explore the source record for details and available documents.

Aged↗
PubMed1975

The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects.

The distribution of X-ray induced aberrations between trypsin-banded regions within human chromosomes has been studied in over a thousand cells from normal and abnormal individuals. An analysis of this data has been performed for each type of aberration separately, taking into account the relative amount of material at risk in reach region. A number of significant deviations from expectation were detected but many of these could be explained in terms of the failure of detection of some aberrations.

Chromosome Aberrations↗
PubMed1975

Pituitary sensitivity to 50 micro g LH/FSH-RH in subjects with anorexia nervosa in acute and recovery stages.

Gonadotrophic output was measured in response to a 50-mug dose of luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH) in subjects with anorexia nervosa. A diminished response was found in subjects of low body weight, and in some a response occurred with increments of plasma FSH greater than those of LH. With restoration of body weight the response to the releasing factor was similar to that usually observed in healthy men and women.

Adolescent↗
PubMed1972

How many acute beds do we really need?

At the end of 1972 two new "best-buy" district general hospitals should open at Bury St. Edmunds and Frimley, eventually serving their catchment areas at a ratio of two acute beds per 1,000 population. This study shows that one of these areas is already operating below this projected target as a result of a considerable decline in the bed ratio over the past decade. Drastic shortening of the average length of stay has permitted an increase in admission rates from 60 to 79 per 1,000 population over the decade, while costs per case measured at constant prices have fallen. These changes have taken place more rapidly than in the U.K. generally. The evidence points to the pattern of clinical management as the main reason for this and suggests that similar gains could be achieved on a national scale, even without waiting for new buildings and expanded community services.

Costs and Cost Analysis↗