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Biomedical subjects

M Wexler

Publications and source records attributed to M Wexler.

At least 55 records · Page 3Linked to original sources
PubMed1989

Stereotactic radiosurgery for fractionated radiation: a proposal applicable to linear accelerator and proton beam programs.

A stereotactic radiosurgery technique is described which allows stereotactic radiation therapy to be easily fractionated on a daily or weekly basis. This permits adequate and safe radiation therapy to lesions larger than 2.5 cm, such as large arteriovenous malformations, and possibly safer radiation to smaller lesions near crucial intracranial structures. The technique utilizes external scalp landmarks and avoids the need for standard stereotactic head devices.

Equipment Design↗
PubMed1989

A dentist oriented fear reduction technique: the iatrosedative process.

This article describes a treatment process that significantly reduces learned dental fear and can be performed by the dentist in 30 to 40 minutes. The findings support the conclusion that the process is effective for calming the fearful dental patient. The iatrosedative process is cost and time effective. It is a procedure the dentist can learn readily, and it can substantially diminish the fear that interferes with treatment.

Adult↗
PubMed1988

The influences of fear, anxiety, and depression on the patient's adaptive responses to complete dentures. Part II.

The classification system of maladaptability presented in a previous paper was reviewed in the present one. Three major sources that significantly influence patient responses to tooth loss and subsequent dentures were discussed. They are parental influences, the symbolic significances of teeth, and current life circumstances. Each of the maladaptive categories is represented by these histories.

Adaptation, Psychological↗
PubMed1987

The influences of fear, anxiety, and depression on the patient's adaptive responses to complete dentures. Part I.

Loss and body image can result in anxiety, depression, or both and can affect a patient's adaptive capacity to accept edentulism and complete dentures. A specific classification system has been presented to identify responses by individuals who are made edentulous. Three types of maladaptive responses are considered as probable consequences of fear, anxiety, and depression associated with tooth loss and complete dentures. In maladaptive class 1, the patient adapts physically but is maladaptive psychologically; thus suffering some impairment of the quality of life. In maladaptive class 2, the so-called "difficult patient" is maladaptive physically and psychologically and keeps the doctor involved technically and emotionally for a protracted period of time. The maladaptive class 3 patient collapses with the loss of teeth. Physical and emotional maladaptibility is accompanied by much suffering and social withdrawal.

Adaptation, Psychological↗
PubMed1984

Bioactive parathyroid hormone in canine progressive renal insufficiency.

Bioactive parathyroid hormone and hormonal actions were monitored as hyperparathyroidism evolved in a model of progressive canine renal failure. Circulating levels of bioactive and immunoreactive parathyroid hormone rose as renal insufficiency worsened, but elevations, especially in bioactivity, were most marked in the final stage of uremia. By gel filtration analysis, the major circulating bioactive moiety was similar to the major glandular form of parathyroid hormone, although a smaller-molecular-weight entity was seen in the final stage of renal failure. Renal phosphate threshold fell, urinary hydroxyproline corrected for glomerular filtration rose, and plasma 1,25-dihydroxyvitamin D fell but remained detectable, as renal function deteriorated. The results demonstrate a progressive rise in bioactive parathyroid hormone, show the appearance of a small-molecular-weight bioactive entity in severe renal disease, and correlate effects of the rising bioactive parathyroid hormone with changes in renal phosphate handling and with skeletal resorption.

Animals↗
PubMed1984

Discordant disappearance of bioactive and immunoreactive parathyroid hormone after parathyroidectomy.

The disappearance of plasma PTH after parathyroidectomy was assessed in patients with primary hyperparathyroidism and normal renal function, chronic renal failure or restored renal function (after transplantation). Plasma PTH levels were determined by renal cytochemical bioassay and by midregion and carboxyl-terminal RIAs. Baseline PTH levels were lower in each patient when assessed by bioassay than when determined by RIA, and the rate of hormone disappearance was faster when determined by bioassay than when measured by RIA. This difference was accentuated in chronic renal failure due to prolongation of the disappearance rates of midregion and carboxyl-terminal immunoreactivity. The half-life of bioassayable hormone in patients with chronic renal failure was prolonged less than 2-fold compared to the half-life in patients with normal or restored renal function. The results emphasize the discordance between levels of bioactive and immunoreactive hormone regardless of renal function, demonstrate that this discordance is augmented after acute reduction in circulating hormone, and show that it is further increased when kidney function is impaired. The studies also implicate extrarenal mechanisms as a major factor in the clearance of bioactive hormone in established renal failure.

Adult↗
PubMed1984

Single-beam radiotherapy knife. A practical theoretical model.

A feasibility study reveals that a standard linear accelerator, with only slight modification, can function in a manner similar to Leksell's multiple cobalt radiation device. A high radiation dose can be delivered to a 1-cm or 0.5-cm volume target with insignificant radiation effect on the surrounding tissue.

Models, Biological↗
PubMed1980

The inter-relationship of vertigo and stress.

Our research indicates that Meniere's disease is not caused by psychologic disorders. In a 1977 study it was demonstrated that the patient with Meniere's disease is in a stressful situation. The psychologic profile is not significantly different in Meniere's and non-Meniere's vertiginous patients. The patient should be treated for his physical disease and be given support for the emotional effects of the vertigo and other symptoms. Meniere's disease causes emotional problems. Emotional problems do not appear to cause Meniere's disease.

Female↗
PubMed1979

The abnormally patent eustachian tube. Alterations in psychological status resulting from polytef paste injections.

Several authors have noted that patients with an abnormally patent Eustachian tube (APET) seem to be psychologically disturbed. We investigated the psychological status of these patients before and after treatment with polytef paste (Teflon) injections. Twelve women were evaluated by a series of tests designed to catalog the nature and intensity of the symptoms, the degree to which symptoms affected the patient, psychopathological trends, and an assessment by the patients of improvement. Results prior to treatment indicated that the patients' symptoms were quite disturbing and were moderately disabling; such symptoms affected concentration, and a marked decrease in the enjoyment of life was noted. After treatment, a notable decrease in APET symptoms was reported, with a parallel decline in emotional disturbances. Patients felt less depressed, anxious, and angry, and they reported that the quality of life was much improved. These findings indicate that physical symptoms can have profound effects on emotional status. In such cases, the most effective psychological treatment is control of physical symptoms rather than psychiatric referral.

Adult↗
PubMed1978

Mental health and dental education.

The relationship between mental health and the educational process in dental school has rarely been explored. In the author's experience as the mental health consultant at the USC School of Dentistry, several focal points of conflict do influence academic effectiveness. These problem areas are often marked by a variety of physical or psychological symptoms such as anxiety--sometimes of panic proportions--gastrointestinal disturbances, and the like. These are frequently related to fear of failure, being exposed as being intellectually inept and fraudulent, neurotic competitive needs, real and unreal paranoid attitudes toward instructors, the student's expectations as to what his or her "silent partners" require to him or her, and the effect dental education has on marriage.

Anxiety↗
PubMed1978

Isothermic and kinetic studies of uremic metabolite adsorption with Ambersorb XE-344 resin.

Ambersorb XE-344 resin is specific for certain metabolites because of unique pore size distribution and surface chemistry. Affinities are greatest for molecules which are significantly aromatic or nonpolar. For clinical purposes, however, the capacity for and kinetics of adsorbing certain aliphatic nitrogenous metabolites (e.g., guanidine) may enhance dialysis treatment as well. While significant affinity for peak 7c has been demonstrated, the resin does not adsorb the steroid, glycoprotein, or polypeptide molecules thus far tested. Despite the carbonaceous nature of Ambersorb XE-344, it does not adsorb the inorganic electrolytes.

Adsorption↗