Search PubMed⌕ Search

Biomedical subjects

M Wender

Publications and source records attributed to M Wender.

At least 127 records · Page 7Linked to original sources
PubMed1977

[Experiences in intensive therapy of apoplectiform pictures of cerebrovascular insufficiency].

Our observations indicate that attention should be paid primarily to the following, in the sequence given, when applying intensive therapy to patients suffering from apoplectiform phenomena of cerebro-vascular insufficiency: keep the respiratory passages open, prevent inflammatory processes, especially bronchopneumonia, give an optimum supply of calories, water and electrolyte to patients in the comatose state, compensate for disturbances in the central regulation of respiration and circulation, combat disturbances of the acid-base balance and prevent cerebral oedema and hyperthermia from central causes. The report was to emphasize the gasometric results of our studies which indicated that 65 per cent of the patients in this group suffer from significant hypoxia and that respiratory alkalosis occurred in 34 per cent. The cause seems to be a disturbance in the respiratory passages which leads to hyperventilation and to subsequent respiratory alkalosis.

Alkalosis, Respiratory↗
PubMed1976

Activity of acid phosphatase and TPP-ase at a fine structure level in the neuroglia as related to myelination of the brain.

An ultrastructural investigation of the activity of acP and TPP-ase in the neuroglia of different developmental stages of the rabbit corpus callosum was performed. The observations made, lead to following conclusions: 1. The strongest demonstration of end products of acP activity was observed in the large dense bodies of oligodendrocytes at the culminating period of myelination gliosis. 2. At the peak of myelinogenesis a rise in the TPP-ase activity in the oligodendrocytes was localized mainly in the Golgi apparatus. However even in this period the Golgi system was only partially filled with reaction precipitates. 3. The increase of lysosomal acid phosphatase and of TPP-ase activity of the Golgi system of oligodendrocytes seems to be connected with the metabolic processes leading to deposition of myelin components.

Acid Phosphatase↗
PubMed1976

Histochemistry of oxidative enzymes in experimental allergic encephalomyelitis.

The histoenzymic pattern of oxidative enzymes (G3PD, IDH, SD, G6PD,HBD, NADPH: dehydrogenase) was investigated in experimental allergic encephalomyelitis (EAE) produced in rats according to PATERSON [13]. The results obtained lead to following conclusions: (1) The neuroglia, including the white matter oligodendroglia of immunized rats, exhibits increased oxidoreductase activities; (2) The neuroallergic reaction induces some stimulation of the oxidoreductive metabolism of oligoden-droglia; (3) The enzymatic hyperactivity in EAE does not show any relation to the morphological signs of alterations of the myelin sheath.

Animals↗
PubMed1975

Fatty acid pattern of cerebral lipids in cyanide encephalopathy.

From the analysis of the fatty acid spectrum of the individual lipid fractions of the cerebral white matter in cyanide induced encephalopathy would appear that essentially the phosphatidyl ethanolamine and plasmalogen fractions showed appreciable deviations from the control spectra. The observed changes in the cholesteryl ester composition did not correlate with the macrophage reaction, which is known to appear as late as 14 days after HCN intoxication when morphological signs of demyelination become apparent. Neither was there a correlation between the alterations of the phosphatide fatty acid composition and that of cholesteryl esters. It thus would appear that esterification of cholesterol in the myelin of rats occurring during early stages following cyanide intoxication constitutes one of the primary factors injuring the myelin sheath. The same conclusion seems to be applicable to the changes in fatty acid composition of the white matter phospholipids.

Animals↗
PubMed1975

Histochemistry of oxidative enzymes in the neuroglia in course of myelination.

The histoenzymic pattern of oxidative enzymes (G-6-PDH, G-PDH, ICDH, SDH, HBDH, NADH-2:tetrazolium dehydrogenase) was investigated in the developing neuroglia of rabbit brains, with special regard to the period of myelinogenesis. The obtained results lead to following conclusions: (1) During the early period of postnatal development there is maximal oxidative enzyme activity in ependymal cells, somewhat less reactive are the undifferentiated matrix cells and the differentiating cells of the mantle layer. No distinction can be made between the response of spongio- and neuroblasts. (2) Distinctly increased oxidoreductase activity, as compared to the early period of postnatal development, is demonstrated by the differentiating cells of myelination gliosis, no prevalence being demonstrable for enzymes of the particular metabolic pathways (pentose shunt, glycolysis or Krebs cycle). (3) G-6-PDH, G-PDH and oxidoreductases acting within the citric acid cycle are demonstrable only in single cells of the interfascicular oligodendroglia of adult rabbit brains, while almost all cells exhibit appreciable activity of HBDH and NADH-2 tetrazolium dehydrogenase.

Animals↗