Search PubMed⌕ Search

Biomedical subjects

M Weigert

Publications and source records attributed to M Weigert.

At least 109 records · Page 6Linked to original sources
PubMed1975

[Stimulation of longitudinal growth of long bones through electrical current. Scintigraphic examinations on ribbit tibiae].

Report on szintigraphical examinations using 87-mSr in young rabbits treated by direct current of different intensity varying from 2.5 to 40 micro-Ampère. The current was applicated to one tibia using the other as comparison. Corresponding to the realised growth-increase by electric stimulation there was found an increased uptake of 87m-Sr in the electro-stimulated tibia in all 16 rabbits.

Animals↗
PubMed1975

[Management in avascular necrosis of the femoral head (author's transl)].

For differentiated indication for operative treatment of avascular necrosis of the femoral head following points have to be considered: age, sex and profession of the patient, precedent treatments, state of contralateral and neighbouring joints. -- Methods of operation: Osteotomy for redistribution, filling with spongious bone and muscle-pedicle-bone graft, transplantation of homeoplastic osteochondral cups of the femoral head, Smith-Petersen-Cup arthroplasty- alloarthroplastic replacement of the femoral head, total replacement of the hip joint, resection of the femoral head and angulation-osteotomy of the diaphysis, arthrodesis of the hip joint. These methods are discussed with regard to personal conditions, surgical techniques, postoperative treatment as well as their advantages and disadvantages. There is no causative treatment of avascular necrosis of the femoral head. Therefore it is especially important to use the different methods appropriate to the special situation.

Adolescent↗
PubMed1975

[Compression arthrodesis of the knee joint].

The results of 42 cases of compression arthrodesis of the knee joint during a 5.5 years period are reviewed. Main indications were degenerative, rheumatoid and posttraumatic arthrosis and tuberculosis of the knee joint. Other differential indications and the operative procedure following the Charnley-Müller method are described. The complications - pseudarthrosis, infection, false rotation - are discussed.

Adult↗
PubMed1974

Immunochemical analysis of the idiotypes of mouse myeloma proteins with specificity for levan or dextran.

This paper deals solely with idiotypic determinants, the configurations of which are modified when the antibody bearing them interacts with its ligand. This phenomenon is measured as an inhibition of the reaction between anti-idiotype and idiotype. Two points are made: (a) The assay for ligand-modifiable determinants can be used to determine the "size" of the combining site. This is illustrated here with the anti-alpha(1 --> 6) dextran mouse myeloma immunoglobulin W3129. Whether the interaction between a homologous series of alpha(1 --> 6) oligosaccharide ligands and the combining site of W3129 is measured by inhibition of precipitation with alpha(1 --> 6) dextran (4) or of binding of W3129 to anti-W3129 idiotype, the finding is the same. The order of inhibition is isomaltohexaose = isomaltopentaose >> isomaltotetraose > isomaltotriose >>> isomaltose. The combining site is optimally complementary to isomaltopentaose. (b) Cross-idiotypic specificity is closely correlated with cross-combining specificity; the converse is not true. This is illustrated here with three groups of mouse myeloma immunoglobulin, each specific for alpha(1 --> 3) dextran, alpha(1 -->6) dextran, beta(2 --> 1) or beta(2 --> 6) levan. If a given anti-idiotypic serum cross-reacted with several myeloma proteins, they always had similar combining specificity. Thus the three proteins, J558, MOPC 104E, and UPC 102, which cross-react with anti-J558 have combining specificity for alpha(1 --> 3) dextran; cross-reacting W3082, UPC 61, and Y5476 have specificity for levan; and cross-reacting W3129 and W3434 have specificity for alpha(1 --> 6) dextran. This extends previous studies with proteins specific for phosphorylcholine (7) or gamma-globulin (8). As expected, the converse is not true, for proteins may have combining specificity for alpha(1 --> 6) dextran e.g. QUPC 52, or levan e.g. J606, UPC 10 and yet not carry the above-mentioned reference idiotypes. The correlation between cross-idiotypic and combining specificity breaks down when idiotypic determinants which are not modifiable by ligand are studied. The implications of this are pointed out since most investigations deal with ligand-nonmodifiable determinants.

Animals↗
PubMed1974

Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes.

The N-terminal 20 residues of 13 heavy immunoglobulin chains from myeloma protein of the BALB/c mouse are compared with the same residues of 15 other heavy chains described in the literature. Sixteen of 28 sequences are different from one another. These proteins fall into four major sets, with 18 of the proteins in the largest set being further divisible into at least five subsets. This pattern of diversity suggests there are at least eight germ line genes coding for the variable regions of mouse heavy chain. Many of the immunoglobulins from which these heavy chains are derived exhibit binding activity for various haptens. The differing hapten specificities are closely correlated with distinct primary amino-acid sequences.

Amino Acid Sequence↗