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Biomedical subjects

M Weber

Publications and source records attributed to M Weber.

At least 721 records · Page 40Linked to original sources
PubMed1983

[Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance].

From the analysis of 115 cases of primary generalized epilepsies treated for a mean duration of 43 months with sodium valproate as sole therapy, it appears that: the mean effective daily dosage is 21 mg/kg; the efficacy of valproate proved excellent in 82.6% of cases (seizures fully controlled: 74%, seizures occurring exceptionally: 9%); a loss of activity was never observed; in these circumstances of prolonged administration of the drug, no signs of major intolerance were seen; side-effects occurred in 29% of cases, including 20% long-term effects (weight gain, essential tremor); 64 series of laboratory tests including 15 parameters made it possible to evaluate the hematological, hepatic and pancreatic tolerance of valproate: the majority of the tests were normal. The authors believe that during long-term therapy with valproate, monitoring does not need to include the routine performance of liver function tests, but that it would be more advisable, should a suggestive clinical sign be noted, to investigate the platelet count, coagulation (partial activated thromboplastin time) and protein synthesis (fibrinogen).

Adult↗
PubMed1983

Persistence of acquired immunity to Sarcocystis miescheriana infection in growing pigs.

Sixteen 8-week-old pigs were each experimentally immunized by subclinical infections with 10(3) Sarcocystis miescheriana (syn. S. suicanis) sporocysts and 8 other pigs served as non-immunized controls. Four groups of pigs (each consisting of 4 immunized plus 2 control pigs) were then challenged by infection with 3 X 10(6) sporocysts at either 40, 80, 120 or 160 days post-immunization (dpi) to determine the persistence of the protective immunity against acute sarcocystosis. Pigs challenged 40 dpi demonstrated a solid immunity to lethal challenge and disease. They survived challenge following a mild fever phase whereas both controls died from acute disease. This immunity however, did not prevent the further establishment of parasitic cysts within the host musculature following challenge. The protective immunity against acute disease persisted to 80 dpi, but was not evident thereafter. At necropsy, the clinical and pathological findings in all pigs which had been subjected to challenge were consistent with anamnestic responses of sensitized hosts to re-infection.

Animals↗
PubMed1983

[Bronchopulmonary manifestations of Horton's disease. Apropos of a case].

A 78 years old woman developed a pulmonary recurrence four years after the diagnosis of temporal arteritis. The lung biopsy showed the same giant-cells granulomatous lesions with central vessels as the initial biopsy. The recurrence in giant cells-arteritis has already been published but the pulmonary involvement had never been illustrated before by histological data. The difficulties of diagnosis in case of granulomatous angiitis on lung samples is emphasized.

Aged↗
PubMed1983

[Computed tomography of renal angiomyolipomas].

22 cases of angiomyolipoma were studied by computerized tomography. Characteristics of the tumours were density values less than -25 HU in 21 patients; one patient having tuberous sclerosis showed higher attenuation values. In 6 of 22 patients angiomyolipomas were associated with tuberous sclerosis. Two large tumours presented with spontaneous rupture and massive retroperitoneal hemorrhage. CT findings are sufficiently typical for angiomyolipomas and therefore suitable for distinguishing the benign lesion from renal cell carcinoma.

Adolescent↗
PubMed1983

[Captopril induced lichenoid eruption].

The authors report three cases of Captopril induced lichenoid eruption, already unmentionned, as far as they know. This cutaneous adverse reaction seemed to be dose related. Late onset was possible, even after six months of therapy. Violaceous papules or plaques were localized (two cases) or disseminated (one case) on the skin. The oral cavity was spared, but mucous membrane may be involved (localisation on the glans penis in one case). Histopathology was suggestive of lichen, but cellular dermal infiltrate was rather sparse. Immunofluorescent study in one case showed anti-IgM and C4 deposits on dermal colloid bodies. Captopril withdrawal was followed by improvement. Reviewing the literature, the authors are questionning about the fact that chemical structures of Penicillamine, Pyritinol and Captopril are strikingly similar and perhaps causative.

Adult↗
PubMed1983

Ultrasonic findings in analgesic nephropathy.

Thirty-four patients with analgesic nephropathy (AN) were investigated by realtime ultrasonography. In 11 of 14 dialysis patients and in 16 of 20 patients with renal insufficiency calcified renal papillae were documented surrounding the internal echo in a typical garland pattern. Incomplete garland pattern of papillary calcifications or development of hydronephrosis occurred in patients with a history of renal colic due to detachment of necrotic papillae. Moreover, AN was assumed in 10 patients with renal insufficiency of unknown origin after detection of typical ultrasonic signs of AN and confirmed by a hitherto unknown history of analgesic abuse.

Humans↗
PubMed1982

[Electrophysiologic study of Achilles areflexia of aged subjects].

The elderly often presents loss of Achilles tendon reflex. In this electrophysiological study the authors examined 19 patients with loss of the ankle jerk and with no known etiology of peripheral neuropathy. They compared them with 24 subjects who had no areflexia. The study included measurement of the H reflex, of the tendon reflex, of the conduction velocity of Ia fibers and of motor conduction velocity of the tibial nerve. Amplitude of H and tendon response and H/M ratio are diminished in the areflexic group. In 4 cases the H reflex is preserved while the tendon reflex is abolished. The meaning of these impairments is discussed.

Achilles Tendon↗
PubMed1982

[Familial presenile dementia: Gerstmann-Sträussler-Scheinker's syndrome (author's transl)].

A similar affection has developed in eight members from four generations of a family living in the Alsace. The disease is characterized by the onset of a pyramidal, pseudobulbar syndrome and dementia during the third or fourth decade of life. The outcome is fatal after a mean period of three years. Cerebral biopsies in three cases have demonstrated multicentric amyloid plaques differing from senile plaques. Clinical and pathological findings are similar to those currently reported in the literature as being typical of Gerstmann-Sträussler-Scheinker's syndrome. The affection appears as a separate entity: the multicentric plaques, clinical symptomatology, pyramidal or pseudobulbar, cerebellar syndromes, usually preceding dementia, age of onset, course, and familial character or the disorder distinguish it among presenile dementias. Its clinical profile and course are very similar to that of familial cases of Alzheimer's disease, some of which are probably cases of Gerstmann-Strässler-Scheinker's syndrome. Transmission to animals, though inconstant, places it within the group of transmissible dementias among kuru, Creutzfeldt-Jakob's, and familial forms of Alzheimer's disease. The familial nature of the affection and the variability of clinical and pathological features in the same family illustrate the complex relationships between hosts and pathogenic agents in the clinicopathological expression of a disease.

Adult↗
PubMed1982

[Securing the ABO-identity by serafol before blood transfusions (author's transl)].

With the Serafol bedside card the ABO identity can be checked before transfusion in a very quick and simple way. The new bedside card is made from polyester film with a special surface coating indifferent to sera, which absorbs the anti sera to well when it begins to dry, that it contains no intermediatory labile additives. The antisera are applied in four circular areas which are spatially separated from each other and dyed in order to avoid additional labelling mistakes. It is not necessary to dissolve the test sera in water. A drop of the patient's blood and the conserved blood respectively are mixed with the antisera and the result can be read within a minute.

ABO Blood-Group System↗