Biomedical subjects
Publications and source records attributed to M Wannske.
Cardiovascular parameters of 35 patients with multiple injuries are monitored over a period of 7 days. Pulmonary artery pressure, pulmonary vascular resistance, intrapulmonary shunts and cardiac output appear to have a significant prognostic value.
Addition of antibiotics to bone cement is used more and more in orthopedics and traumatology. Indications are discussed: 1. infection prophylaxis in replacement arthroplasty, 2. therapy and recidive prophylaxis in infected arthroplasty, 3. therapy of chronic osteomyelitis. Our own experiments show release of antibiotics from bone cement Palacos and penetration into cortical bone after experimental osteomyelitis. Carbenicillin and Cephalotin show high level of concentration for 2 weeks, after 3 weeks there is no concentration evident. Lincomycin and Gentamycin in the first days show high tissue levels, after decrease and increase again after second week. Gentamycin was examined during 10 months showing high levels after this time.
The release of antibiotics from bone cement palacos into cortical bone after experimental ostemyelitis in sheep was demonstrated by our experiments. High carbenicillin and cephalothin concentration levels were present for 2 weeks, but after 3 weeks were no longer evident. Lincomycin and gentamicin in the first days showed high tissue levels, then decreased and increased again after the 2nd week. Gentamicin was examined over 10 months, producing high levels after this time also.
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