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Biomedical subjects

M Wada

Publications and source records attributed to M Wada.

At least 667 records · Page 37Linked to original sources
PubMed1981

Exercise stress body surface isopotential map in patients with coronary artery disease: comparison with coronary angiographic and stress myocardial perfusion scintigraphic findings.

to locate the ischemic area in 22 patients with angina pectoris, exercise stress body surface isopotential maps (MAPs) were assessed and compared with coronary angiography and myocardial stress scintigraphy. Taking coronary angiographic findings into consideration, 4 types of ischemic MAP responses, i.e., septum and anterior, lateral, inferior, and posterior wall ischemia were postulated. Sensitivity of stress MAP was 71% for the average and more than stress imaging. Specificity of stress MAP was 46% for the average and less than stress imaging.

Angina Pectoris↗
PubMed1981

A case report of pseudohypoparathyroidism (Drezner's type I) associated with probable Bartter's syndrome.

A 24-yr-old male patient that suffered from chronic tetany since school age. At the age of 20 tetanic convulsions occurred due to hypocalcemia. His mother also had chronic tetany due to pseudohypoparathyroidism. At the age of 24, hypocalcemia caused by pseudohypoparathyroidism was noted. Hypopotassemia persisted even when the hypocalcemia improved with the administration of 1 alpha-hydroxycholecalciferol and calcium lactate. Other findings were normal blood pressure, high levels of plasma renin activity and serum aldosterone, a fall in blood pressure after angiotensin II antagonist infusion, blunted pressor response to angiotensin II infusion and hyperplasia of the juxtaglomerular cells. These results were compatible with Bartter's syndrome. Plasma prostaglandins E2 and F2 alpha in standing position were suppressed after indomethacin administration. To our knowledge this is thought to be the first report of a case of pseudohypoparathyroidism associated with probable Bartter's syndrome.

Adult↗
PubMed1980

Immobilized mitochondrial electron transport particle for NADH determination.

Nonphosphorylating electron transport particles (ETP) prepared from beef heart mitochondrion were immobilized in agar gel. The immobilized ETP showed an oxidase activity to both NADH and succinate. The immobilized ETP was reusable. An electrochemical device for the determination of either NADH or succinate was assembled consisting of the membrane-bound ETP and an oxygen probe. The response to succinate was specifically inhibited by the addition of malonate.

Animals↗
PubMed1980

Diagnostic value of body surface map in myocardial infarction: assessment of location, size and ejection fraction as compared with coronary cineangiography and 201Tl myocardial scintigraphy.

The diagnosis of the location and size of old myocardial infarction was made by the map and various indices obtained from the map were correlated with coronary arteriography, left ventriculography, and 201Tl myocardial scintigraphy. Diseased coronary arteries were presumed from Q30, Q40 area and/or peak voltage map and left ventricular wall motion was estimated from subtraction map. There were significant correlations between ejection fraction and sigma R in anterolateral MI (r = 0.51, p less than 0.001) and between ejection fraction and nQ30 in anterolateral (r = -0.47, p less than 0.001) and inferoposterior (r = -0.63, p less than 0.01) MI. Negative correlation was observed between myocardial uptake ratio (MUR) and nQ30 (r = -0.69, p less than 0.001) and positive correlation between MUR and sigma R (r = 0.50 p less than 0.01) in anterolateral MI. Those cases which could not be diagnosed by either ECG or 201Tl scintigraphy were correctly diagnosed by the map and it proved to have an excellent diagnostic accuracy for myocardial infarction.

Adult↗
PubMed1980

Plasma active and inactive renin in patients with diabetes mellitus.

Plasma active and acid activated inactive renin was measured in healthy subjects and in patients with diabetes mellitus. The angiotensin I generated from the incubation of non-acidified plasma with pig renin substrate was expressed as plasma renin concentration (PRC) and that from acidified plasma was expressed as total renin concentration (TRC). The inactive renin concentration (IRC) was calculated as TRC minus PRC. With regard to plasma renin activity (PRA) and PRC, no significant difference was found between normal and diabetic groups. TRC and IRC in diabetics with no clinical sign of microangiopathy were 22.8 +/- 1.7 and 15.2 +/- 1.3 ng/ml/h (mean +/- SE), and these values were not significantly different from those in the healthy subjects (20.5 +/- 1.5 and 13.2 +/- 1.5 ng/ml/h). However, TRC and IRC in diabetics with retinopathy and clinical nephropathy was 38.8 +/- 3.4 and 30.7 +/- 3.2 ng/ml/h, and these values were significantly higher than those in the above two groups, respectively. Moreover TRC and IRC in diabetics with retinopathy and no clinical nephropathy was 33.8 +/- 5.7 and 24.9 +/- 5.5 ng/ml/h, and these values were significantly higher than those in the control group. IRC was not significantly correlated with fasting blood sugar and mean blood pressure levels, however however a significant correlation was found between IRC and BUN, and IRC and P.S.P. excretion in 15 minutes. These findings suggest that increased inactive renin in diabetes mellitus may be related to the progression of the renal lesions associated with diabetic microangiopathy.

Adult↗
PubMed1980

A stereotaxic atlas for diencephalic nuclei of the frog, Rana pipiens.

A stereotaxic apparatus was devised for frogs (Rana pipiens pipiens) by adaptation of a commercially available apparatus. An atlas of orienting illustrations emphasizing detailed structure and distribution of forebrain nuclei was prepared from celloidin sections and paraffin sections. Nomenclature of nuclei is discussed and an attempt made to reconcile various interpretations in the published literature.

Animals↗