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Biomedical subjects

M Wada

Publications and source records attributed to M Wada.

At least 649 records · Page 36Linked to original sources
PubMed1982

Nodular hyperplasia with a central telangiectatic fibrosis in the liver of non-cirrhotic portal fibrosis (idiopathic portal hypertension).

Unusual nodules of hyperplastic hepatocytes were found in the liver of a 64-year-old woman with non-cirrhotic portal fibrosis (idiopathic portal hypertension). These nodules were subdivided by stellate fibrous tissues which, in the center of the nodules, contained conspicuous telangiectatic lesions with congestion. The latter was consisted of markedly dilated sinusoids and fibrosis of their walls either in a lack of hepatocytes or with severly atrophic hepatic column. The lesions were different from already described focal nodular lesions in the liver. No drugs and chemicals could be identified as the causative agents. The small arterial changes, namely, hyalinization and thickening of their walls and luminal narrowing or occlusion, were found in the nodular lesions and also in the remaining hepatic tissues, and might be a causative factor for the nodular lesions.

Endothelium↗
PubMed1982

A case report on disequilibrium hypercalcemia in hyperthyroidism. Comparison of calcium metabolism with other patients with hyperthyroidism.

The patient, a 30-year-old woman, was admitted to Itoh Hospital in February, 1979 for hyperthyroidism. She had a history of pyelonephritis and recurrent urinary tract infection. Laboratory data on admission revealed overt hyperthyroidism (T3: 405 ng/dl, T4: 22.5 micrograms/dl and T3U: 57.--%), severe hypercalcemia of 12.6 mg/dl and hypercalciuria. The PSP excretion and GFR were both decreased. Serum c-PTH was nondetectable. As the thyroid function improved, there was a gradual decrease and later normalization of plasma calcium, phosphate and urinary calcium excretion. When subtotal thyroidectomy was performed on October 19, 1979, hypertrophy of the parathyroid gland was not demonstrated. In comparison with 98 other hyperthyroid patients, the pathogenesis of hypercalcemia was discussed. In conclusion, hypercalcemia in the patient, T. Y., was regarded as a kind of disequilibrium hypercalcemia which resulted from a combination of increased bone turnover and decreased calcium excretion by the kidney.

Adult↗
PubMed1982

[67Ga-emission computed tomography in bronchogenic carcinoma--a comparative study with conventional scintigraphy--].

Both conventional 67Ga scintigraphy and 67Ga emission computed tomography (ECT) were performed in 36 patients with bronchogenic carcinoma to evaluate clinical significance of 67Ga-ECT as an adjunctive method. Each patient received 111 approximately 185 MBq (3 approximately 5 mCi) of 67Ga-citrate intravenously. A rotation gamma camera (Shimadzu LFOV-E) was used for ECT study, and a gamma camera (Searle LFOV) was used for conventional scintigraphy. The detectability of 67Ga scintigraphy with ECT in primary tumors and regional lymph node metastases was compared retrospectively with that of conventional 67Ga scintigraphy alone. There was little improvement in detection of primary and metastatic lesions by adding 67Ga-ECT. Only 3 primary tumors were demonstrated more distinctly by 67Ga-ECT. However, there was no lesion which was detected only by 67Ga-ECT. Our data indicate that inclusion of 67Ga-ECT in the routine examination is unnecessary in cases with bronchogenic carcinoma.

Aged↗
PubMed1981

Gel filtration profile of plasma active and inactive renin in normals and patients with nephrotic syndrome.

The molecular weight of plasma renin from healthy subjects and patients with nephrotic syndrome, in whom we previously reported that plasma inactive renin was increased, was studied by gel filtration. Activation was performed by acid treatment. The plasma from healthy subjects contains a low molecular weight from of renin (40 000) and a high molecular weight form which can be separated into two peaks of 52 000 and 60 000. After acid activation, renin activity was increased in the high molecular form but not significantly in the low molecular form. Although the increase of renin activity in the high molecular weight form after acid activation was larger in patients with nephrotic syndrome, the gel filtration profile was similar to that of healthy subjects.

Chromatography, Gel↗
PubMed1981

An autopsy case of erythropoietic protoporphyria with cholestatic jaundice and hepatic failure, and a review of literature.

A 43-year-old woman with a history of photosensitivity died of hepatic failure following 3 and a half months of unexplained jaundice. The liver was black, showed mild fibrosis and conspicuous pigment deposition in the cytoplasm of the hepatocytes, Kupffer cells and portal macrophages, and within dilated lumina of bile canaliculi and of ductules. The pigment disclosed a striking birefringence and numerous slender electron-dense crystals on electron microscopy. Similar crystals were also found within the cytoplasm of the ductular epithelium. Despite absence of cirrhosis observed in almost all previously described fatal cases the diagnosis of erythropoietic liver with marked protoporphyrin deposition so far have not been described in the cases observed at autopsy.

Adult↗