[DiGeorge syndrome].
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DiGeorge Syndrome↗
Biomedical subjects
M Viander
Publications and source records attributed to M Viander.
The seasonal symptoms of hyposensitized and untreated hay fever patients in relation to birch pollen counts: correlations with nasal sensitivity, prick tests and RAST.
A 2 year prospective study of thirty-eight birch pollen-sensitive hay fever patients under specific immunotherapy and of nineteen untreated control patients showed a significant correlation between the total seasonal symptom scores of the patients and their clinical sensitivities assessed by the RAST and a graded nasal test. The agreement between a positive nasal test and a positive RAST was 74%. In the early season with low pollen counts the onset of symptoms was significantly associated with high sensitivity of the patients, while many patients showed symptoms in the late season irrespective of their nasal and RAST sensitivity. About 90% of both the treated and the untreated patients reported mild symptoms when the pollen count exceeded 80/m(3) in the early season. 80% of them still had symptoms when the count was below 30/m(3) in the late pollen season. Although hyposensitization therapy had no effect on the occurrence of the mild symptoms, the treated patinets had severe symptoms significantly less often than the untreated ones on days with high pollen counts.
Administration, Intranasal↗
Yersinia enterocolitica infection complicated by glomerulonephritis.
A case of mild glomerulonephritis in a 24-year-old man with clinical and immunohistological findings associated with Yersinia enterocolitica serotype 3 infection is described. The role of IgA in the pathogenesis of glomerulonephritis associated with mucosal infection is briefly discussed. Although attempts to demonstrate Y. enterocolitica 3 antigen in the biopsy specimen were unsuccessful, the glomerular deposits of immunoglobulins and complement suggest immune pathogenesis.
Adult↗
Antibodies to gliadin by ELISA as a screening test for childhood celiac disease.
The sera of 309 children who were subjected to jejunal biopsy were tested for antigliadin antibodies (AGA) with enzyme-linked immunosorbent assay (ELISA) in order to evaluate the usefulness of this test as a screening test for childhood celiac disease (CD). Thirty-one children had flat intestinal mucosa later confirmed to be due to CD. Ninety percent of these children had significantly elevated levels of IgA class AGA and 94% had significantly elevated levels of IgG class AGA as compared to standard references. Two hundred and seventy-eight children had normal villous structure. In this group, 37 children out of 271 (seven excluded because of selective IgA deficiency) had elevated levels of IgA class AGA, and 93 children out of 278 had elevated levels of IgG class AGA. We conclude that ELISA-AGA is suitable as a screening test for childhood CD.
Adolescent↗
Milk versus no milk in rapid refeeding after acute gastroenteritis.
Sixty-five infants (mean age 14.7 months, range 6-34 months), hospitalized for acute gastroenteritis, were treated with oral rehydration and rapid reintroduction of full feedings appropriate for age. Cow's milk and milk products were eliminated from the diet of 27 infants, whereas the remaining 38 children continued to receive their usual milk and milk products as parts of the mixed diet. There was no difference between the groups in the clinical recovery from diarrhea. No child had prolonged diarrhea. No new cases of clinical atopy were observed at 1-month follow-up, and there were no significant increases in the total or milk-specific IgE levels. Serum IgG and IgA antibodies to beta-lactoglobulin and alpha-casein were initially present in the majority of the children, but there were no appreciable changes in these cow's milk antibodies after gastroenteritis, regardless of the type of diet. It is concluded that cow's milk and milk products can be safely given in acute gastroenteritis as parts of the mixed diet for children over 6 months of age. Rapid reintroduction of feedings is beneficial for recovery from diarrhea, and there appears to be little need for dietary restrictions in this age group.
Acute Disease↗
Triad of nephrotic syndrome, antinuclear antibodies and positive lupus band test.
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Adult↗
In vitro lymphoproliferative response to Yersinia: depressed response in arthritic patients years after Yersinia infection.
The persistence of lymphocyte transformation response to Yersinia was studied three to six years after Yersinia infection in subjects who had or had not suffered from reactive arthritis. In persons who had had arthritis, significantly weaker response to Yersinia was found than in those who had recovered without developing arthritis. The same held true also for the response to Klebsiella. These results support and extend our earlier observations of a depressed lymphocyte transformation response to Yersinia during the course of Yersinia arthritis. This phenomenon may be linked to the individual's susceptibility to arthritic complications after Yersinia infection.
Arthritis, Infectious↗