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Biomedical subjects

M Ventz

Publications and source records attributed to M Ventz.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Acromegaly and colorectal proliferations].

Hypersomatotropism causes not only the typical acromegalic symptoms but also very often a splanchnomegaly with participation of the enteron. We performed a colonoscopy in 16 patients with a persistent active acromegaly in spite of full used therapy possibilities. Only in four cases (25%) we could find a polyp. They were distributed on the colon transversum (one), descendens (one) and sigmoideum (two). Three of them (histology: tubular adenoma) had a diameter of less than 5 mm. Only one adenoma had an extent of 3.5 x 3 x 2.5 cm (histology: tubular-villous adenoma). Not any polyp showed signs of malignity. There existed no relations between the coloscopic findings, the degree of activity and the duration of illness. Localisation, histology, frequency and age distribution of the found out polyps of our patients were in the range of real frequency of the occurrence of colorectalic neoplasms. We conclude: Acromegaly is correlated not more than accidentally with colorectalic neoplasms (benign, malignant). Therefore preventive medical examinations of acromegalic patients are not rich in meaning.

Acromegaly↗
PubMed1986

[Prolactinoma in the male].

In a retrospective study the medical records of 13 male patients with macroprolactinomas were evaluated concerning anamnestic data, clinical, endocrinological and localisation-diagnostic findings as well as therapeutic measures. The main symptoms were disturbances of vision and impaired potency and impaired libido, respectively. The ophthalmological complaints nearly exclusively caused the patients to see the doctor. Clinically the signs of hypogonadism were found. The diagnosis was ascertained by increased serum prolactin levels, ophthalmological findings, X-ray of the sella, cranial computed tomography as well as angiography of the carotid. The operative treatment did not show any normalization of the serum prolactin levels. The rate of recidivations after exclusive operative treatment was high. An additional medicamentous therapy with dopamine agonists is nearly always necessary after operation. Whether or not bromocriptine shall be used as primary therapy, must be decided on in the individual case.

Adolescent↗
PubMed1986

[Hypophyseal coma].

Explore the source record for details and available documents.

Adrenal Cortex Hormones↗
PubMed1985

[Bromocriptine therapy of prolactinoma in pregnancy].

A report is given about the course of pregnancy and delivery of two patients with prolactin-producing pituitary adenomas and therapy with bromocriptine. Different views about treatment of prolactinomas in pregnancy are discussed. Pregnancy care has to be in close cooperation between endocrinologists and obstetricians.

Adenoma↗
PubMed1984

[Effect of thyroid hormones on noradrenaline-stimulated lipolysis in obesity].

11 extremely adipose patients were over 4 days loaded with a noradrenalin infusion of 0.1 microgram/kg body weight/minute over 60 minutes before and after a daily application of 200 micrograms tri-iodothyronine. The determination of the free fatty acids and of glycerin resulted in a significant elevation basally as well as after stimulation with noradrenalin. Thus the lipolytic influence of the thyroid hormones is confirmed under in-vivo-conditions. The possible mechanisms of lipolysis in the fatty tissue are discussed on the basis of literature.

Adolescent↗
PubMed1982

[The behavior of the thyrotropin-releasing hormone test in fasting with and without triiodothyronine administration].

It is reported on the performance of the 400 microgram TRH/TSH test in adipose persons in the course of a zero diet and on the effects of an application of 50 micrograms tri-iodothyronine during 7 days on the TRH/TSH test on the same conditions. During total fasting the basic and TRH-stimulating TSH-level shows a slight tendency of decrease, but scarcely significant changes. After application of 50 micrograms tri-iodothyronine an unequivocal suppression of the TSH-concentration in the serum is to be recognized. By these results and with the help of literary data by means of the most sensitive test of the diagnostics of hypothyroidism a general hypofunction of the pancreas could be excluded, as it was supposed in the low T3 syndrome. But tri-iodothyronine deficiency in some tissues is still discussed at present.

Adolescent↗
PubMed1982

[Results of thyroid hormone therapy in bland struma].

2,191 patients with bland struma were treated with tri-iodothyronine and a mixed preparation (thyreotom) for at least 2 years. Several clinical criteria were used for judgement. A good result could be obtained in 78.3 to 51.2% depending on the size of the struma (I-III). While in diffuse strumata good results were obtained in 87.8 to 69.0%, in nodular goitres we were successful only in 52.0-32.9%. The therapy may be successful at every age. Since with growing age the nodular goitres prevail, the chances of success become smaller. For the same reason there is a close correlation between age of the goitre and the therapeutic effect. The rate of success continuously decreases with growing age of the goitre. From this results that the therapy in goitre must begin early, before nodular and regressive changes, respectively, render the treatment difficult or render an acceptable result difficult.

Adult↗
PubMed1981

[Enlargement of the sella in primary hypothyroidism].

Length of the sella, depth of the sella and surface of the sella profile of 37 primary hypothyroids were compared with a normal group. All the three parameters were significantly different, though situated in the normal area. The results are discussed on the basis of literature. The reactive formation of hypophyseal tumours at adult age in primary myxoedema is relatively rare. However, in every enlargement of the sella also a primary hypothyreosis should be regraded differential-diagnostically. A therapeutic experiment with thyroid hormones should always be made.

Adolescent↗
PubMed1980

[Problems of treatment with thyroid hormones. Thyroxin monotherapy or a T3/T4 combination preparation?].

At the instance of T3- and T4-measurements of the daily profile in the serum after the application of triiodothyronine and the usual T3/T4-combination preparations is referred to the unphysiologically high T3-peaks 2 to 4 hours after the application depending on the proportion of triiodothyronine. The three distributed all over the day doses of e.g. thyreotom do not sufficiently smooth such undulations. The lacking triiodothyronine serum peaks after application of pure thyroxin as a bolus confirm the demand of a thyroxin monotherapy. Nevertheless, for answering the question of the "physiologic thyroid hormone therapy" some problems remain open which are discussed. Taking into consideration these facts (particularly conversation and extrathyroid influence of the thyroid hormone metabolism) a combination of T3 to T4 in the ratio 1:10 is recommended.

Adult↗
PubMed1979

[Gynecomastia].

Gynaecomasty is no disease sui generis, but a symptom which may underlie different causes. Steroidal substances, above all oestrogens play a dominating role in these cases. Diagnostic and therapeutic measures must comply with the known causal factors. The gynaecomasty during puberty exhibits a high spontaneous retrogression rate. Only seldom an operative correction becomes necessary.

Adolescent↗
PubMed1979

[Behavior of the erythrocyte glucose-6-phosphate dehydrogenase in patients with functional thyroid disorders and in hyperthyroxinemic rats].

This paper deals with the activity of glucose-6-phosphate dehydrogenase in patients with hyper- and hypothyroidism as well as in hyperthyroxinaemic rats. The activity of glucose-6-phosphate dehydrogenase is enhanced in red blood cells of hyperthyreotic patients and hyperthyroxinaemic animals. The activity will be decreased to normal range in patients by administration of antithyreotic drugs, such as thiamazole. Patients with hypothyroidism exhibit decreased enzymatic activity. It is suggested that thyroid hormones stimulate the HMP-shunt in red blood cells as a defence mechanism against additional oxidative stress.

Animals↗
PubMed1978

[Thyroid gland function in obesity].

It is reported on in vitro tests of the thyroid gland in 7 males with normal weight and 9 adipose ones. No clear difference was found in the two groups. The TSH level, too, after TRH stimulation is not significantly different so that a latent primary hypothyroidism cannot be ascertained.

Adult↗