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M Ventz

Publications and source records attributed to M Ventz.

At least 19 recordsLinked to original sources
PubMed1995

Growth hormone-binding protein-related immunoreactivity in the serum of patients with acromegaly is regulated inversely by growth hormone concentration.

In this report we describe a newly developed radioimmunoassay (RIA) for the determination of the high-affinity growth hormone-binding protein (GHBP) in human blood. Using this RIA for the measurement of GHBP in serum of 29 patients with acromegaly, decreased concentrations were found compared to the normal range, depending on the activity of the disease. Growth hormone-binding protein was correlated inversely to log GH (r = -0.7, p < 0.001). A weaker relationship was shown between the GHBP activity determined in a functional assay based on charcoal separation and log GH (r = -0.51, p < 0.01). While insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) were correlated directly to log GH (r = 0.77 and r = 0.66, p < 0.001), an inverse and weaker relationship was evident between GHBP measured by RIA and IGF-I or IGFBP-3 (r = -0.61 and r = -0.57, p < 0.01). In contrast, no correlation could be detected between data of the functional GHBP assay and IGF-I or IGFBP-3.(ABSTRACT TRUNCATED AT 250 WORDS)

Acromegaly↗
PubMed1993

Measurement of insulin-like growth factor I (IGF-I) in normal adults, patients with liver cirrhosis and acromegaly: experience with a new competitive enzyme immunoassay.

A competitive enzyme immunoassay for the determination of human insulin-like growth factor I in microtiter plates was established. Using a polyclonal antiserum raised in rabbits against hIGF-I ovalbumin conjugate the assay system was able to detect IGF-I at a range of 12-800 pg/well with a sensitivity of 10 pg/well. It showed a low (< 0.5%) cross reactivity with hIGF-II. The serum concentrations of IGF-I found by EIA agreed well with those found in a conventional RIA (r = 0.965, p < 0.001). Effects of age and sex on IGF-I levels were studied in 260 normal adults. There was no evidence for sex differences but a steep decline of values from the third to the fourth and from the eight to the ninth decade, respectively. To asses the diagnostic capability of the IGF-I determination in liver cirrhosis, 71 sera of patients classified according to Child classes (A-C) were measured. Although significantly diminished concentrations were found in class B vs A and in class C vs B, the diagnostic sensitivity in cross-sectional examinations proved to be low (class A: 0.33, class B: 0.67). Only in the case of extensively destroyed liver parenchyma (Child C: 0.94) IGF-I was a good indicator of impaired hepatocellular capacity. In 29 patients with acromegaly serum IGF-I levels were investigated. All patients with active acromegaly showed increased IGF-I levels. In contrast, in inactive or weakly active acromegaly values were considerably lower.(ABSTRACT TRUNCATED AT 250 WORDS)

Acromegaly↗
PubMed1988

[Diagnosis and therapy of thyroiditis].

In general a heterogeneous group of diseases of the thyroid gland which have a common histological picture of an inflammatory infiltration is referred to as thyroiditis. In the last years increasingly is paid attention to these diseases, since they apparently become more frequent and diagnostics and also therapy have improved. In a review the diagnostic and therapeutic possibilities are discussed, whereby the most frequent forms, the Hashimoto and de Quervain thyroiditis, are described in detail. The individual forms of thyroiditis and particularly the thyroid malignoma are to be distinguished differential-diagnostically.

Humans↗
PubMed1987

[Results of thyrostatic therapy of hyperthyroidism in patients with Basedow's disease and disseminated autonomy].

Up to now the results of drug treatment are unsatisfying. Treatment of more than 1-2 years did not decrease the occurrence of relapses. Thyroid suppression test and TRH test give the same indications concerning the outcome in cases with Graves' disease and disseminated autonomy (short-time prognosis). The relapse rate is distinctly higher in Graves' disease than in cases with disseminated autonomy (goitre class 3 excluded).

Follow-Up Studies↗
PubMed1987

[Acromegaly and colorectal proliferations].

Hypersomatotropism causes not only the typical acromegalic symptoms but also very often a splanchnomegaly with participation of the enteron. We performed a colonoscopy in 16 patients with a persistent active acromegaly in spite of full used therapy possibilities. Only in four cases (25%) we could find a polyp. They were distributed on the colon transversum (one), descendens (one) and sigmoideum (two). Three of them (histology: tubular adenoma) had a diameter of less than 5 mm. Only one adenoma had an extent of 3.5 x 3 x 2.5 cm (histology: tubular-villous adenoma). Not any polyp showed signs of malignity. There existed no relations between the coloscopic findings, the degree of activity and the duration of illness. Localisation, histology, frequency and age distribution of the found out polyps of our patients were in the range of real frequency of the occurrence of colorectalic neoplasms. We conclude: Acromegaly is correlated not more than accidentally with colorectalic neoplasms (benign, malignant). Therefore preventive medical examinations of acromegalic patients are not rich in meaning.

Acromegaly↗
PubMed1986

[Prolactinoma in the male].

In a retrospective study the medical records of 13 male patients with macroprolactinomas were evaluated concerning anamnestic data, clinical, endocrinological and localisation-diagnostic findings as well as therapeutic measures. The main symptoms were disturbances of vision and impaired potency and impaired libido, respectively. The ophthalmological complaints nearly exclusively caused the patients to see the doctor. Clinically the signs of hypogonadism were found. The diagnosis was ascertained by increased serum prolactin levels, ophthalmological findings, X-ray of the sella, cranial computed tomography as well as angiography of the carotid. The operative treatment did not show any normalization of the serum prolactin levels. The rate of recidivations after exclusive operative treatment was high. An additional medicamentous therapy with dopamine agonists is nearly always necessary after operation. Whether or not bromocriptine shall be used as primary therapy, must be decided on in the individual case.

Adolescent↗
PubMed1986

[Hypophyseal coma].

Explore the source record for details and available documents.

Adrenal Cortex Hormones↗
PubMed1985

[Bromocriptine therapy of prolactinoma in pregnancy].

A report is given about the course of pregnancy and delivery of two patients with prolactin-producing pituitary adenomas and therapy with bromocriptine. Different views about treatment of prolactinomas in pregnancy are discussed. Pregnancy care has to be in close cooperation between endocrinologists and obstetricians.

Adenoma↗
PubMed1984

[Effect of thyroid hormones on noradrenaline-stimulated lipolysis in obesity].

11 extremely adipose patients were over 4 days loaded with a noradrenalin infusion of 0.1 microgram/kg body weight/minute over 60 minutes before and after a daily application of 200 micrograms tri-iodothyronine. The determination of the free fatty acids and of glycerin resulted in a significant elevation basally as well as after stimulation with noradrenalin. Thus the lipolytic influence of the thyroid hormones is confirmed under in-vivo-conditions. The possible mechanisms of lipolysis in the fatty tissue are discussed on the basis of literature.

Adolescent↗
PubMed1982

[The behavior of the thyrotropin-releasing hormone test in fasting with and without triiodothyronine administration].

It is reported on the performance of the 400 microgram TRH/TSH test in adipose persons in the course of a zero diet and on the effects of an application of 50 micrograms tri-iodothyronine during 7 days on the TRH/TSH test on the same conditions. During total fasting the basic and TRH-stimulating TSH-level shows a slight tendency of decrease, but scarcely significant changes. After application of 50 micrograms tri-iodothyronine an unequivocal suppression of the TSH-concentration in the serum is to be recognized. By these results and with the help of literary data by means of the most sensitive test of the diagnostics of hypothyroidism a general hypofunction of the pancreas could be excluded, as it was supposed in the low T3 syndrome. But tri-iodothyronine deficiency in some tissues is still discussed at present.

Adolescent↗
PubMed1982

[Results of thyroid hormone therapy in bland struma].

2,191 patients with bland struma were treated with tri-iodothyronine and a mixed preparation (thyreotom) for at least 2 years. Several clinical criteria were used for judgement. A good result could be obtained in 78.3 to 51.2% depending on the size of the struma (I-III). While in diffuse strumata good results were obtained in 87.8 to 69.0%, in nodular goitres we were successful only in 52.0-32.9%. The therapy may be successful at every age. Since with growing age the nodular goitres prevail, the chances of success become smaller. For the same reason there is a close correlation between age of the goitre and the therapeutic effect. The rate of success continuously decreases with growing age of the goitre. From this results that the therapy in goitre must begin early, before nodular and regressive changes, respectively, render the treatment difficult or render an acceptable result difficult.

Adult↗
PubMed1981

[Enlargement of the sella in primary hypothyroidism].

Length of the sella, depth of the sella and surface of the sella profile of 37 primary hypothyroids were compared with a normal group. All the three parameters were significantly different, though situated in the normal area. The results are discussed on the basis of literature. The reactive formation of hypophyseal tumours at adult age in primary myxoedema is relatively rare. However, in every enlargement of the sella also a primary hypothyreosis should be regraded differential-diagnostically. A therapeutic experiment with thyroid hormones should always be made.

Adolescent↗