Neuropharmacological basis of stimulant drug action in attention deficit disorder with hyperactivity: a review and synthesis.
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Animals↗
Biomedical subjects
M V Solanto
Publications and source records attributed to M V Solanto.
A dose-response and time-action analysis of autonomic and behavioral effects of methylphenidate in attention deficit disorder with hyperactivity.
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Attention Deficit Disorder with Hyperactivity↗
DDC-induced amnesia and norepinephrine: a correlated behavioral-biochemical analysis.
Diethyldithiocarbamic acid (DDC), a dopamine-B-hydroxylase inhibitor, when injected into rats 30 min to 6 h before training of a passive avoidance task, impaired formation of long-term memory as indicated by performance on a retention test 24 h later. Performance of the task was at its minimum when injection occurred 2 to 4 h prior to training; recovery was evident in animals trained 5 or 6 h after drug treatment. Catecholamine assay of brains of temporally yoked animals showed that norepinephrine depletion followed a time course paralleling that of the amnesia. These findings support the hypothesis that the degree of memory storage, as reflected in performance following training in a passive avoidance task, can be directly correlated with the level of norepinephrine existing at the time of training.
Animals↗