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Biomedical subjects

M Uwaydah

Publications and source records attributed to M Uwaydah.

At least 37 records · Page 2Linked to original sources
PubMed1977

Cephradine penetration into cerebrospinal fluid and effects of its administration into the cerebral ventricles of cats.

In cats that had high, sustained serum concentrations of cephradine, penetration of the drug into the cerebrospinal fluid (CSF) was poor. Serum cephradine levels were, on the average, 100-fold higher than the CSF levels. On the other hand, the direct injection of cephradine into the lateral cerebral ventricles of cats yielded high CSF cephradine concentrations without evidence of central nervous system toxicity.

Animals↗
PubMed1976

Susceptibility of nonfermentative gram-negative bacilli to tobramycin.

There has been increasing interest in the pathogenic role of nonfermentative gram-negative bacilli in human infections. Except for Pseudomonas aeruginosa, the susceptibility pattern of these organisms to tobramycin has not been evaluated thoroughly. The activity of tobramycin, as compared with that of gentamicin, was tested by the serial broth dilution technique against 178 isolates of nonfermentative gram-negative bacilli obtained from various sources. P. aeruginosa, Pseudomonas stutzeri, Acinetobacter calcoaceticus var. anitratum (Herellea vaginicola), A. calcoaceticus var. Iwoffi (Mima olymorpha), Pseudomonas alcaligenes, and Pseudomonas acidovorans accounted for 82% of all cultures tested. The vast majority of these organisms were susceptible to both tobramycin and gentamicin. Resistance was most common with Alcaligenes odorans; six of 12 isolates were resistant to gentamicin and tobramycin. There was only one isolate of Pseudomonas diminuta; it was highly resistant to both antibiotics.

Alcaligenes↗
PubMed1976

Cefazolin in the treatment of acute enteric fever.

Cefazolin was used in the treatment of nine patients with acute enteric fever proven by positive blood cultures. In seven patients the causative organism was Salmonella typhi and in two it was Salmonella paratyphi B. Minimal inhibitory and minimal bactericidal concentrations of cefazolin against the nine isolates ranged between 1.95 and 3.90 mug/ml. Cefazolin was administered either intramuscularly or intravenously in a daily dose of 3 to 6 g for 11 to 16 days. The mean peak serum antibiotic concentration after a 0.5-g intravenous injection was 64.4 mug/ml, and the mean trough concentration, 3 h later, was 12.7 mug/ml. The highest serum inhibitory dilution at peak level was frequently 1/64, and at trough level it was 1/16 to 1/32. The acute infection was satisfactorily controlled in all patients. Phlebitis, complicating intravenous therapy, in five out of eight patients, was the only side effect observed. Relapse of typhoid fever, as documented by positive blood culture, occurred in one patient 11 days after treatment course was completed. More extensive clinical studies are required before drawing any conclusions regarding the efficacy of cefazolin in acute enteric fever.

Adolescent↗
PubMed1975

Co-trimoxazole compared to chloramphenicol in the treatment of enteric fever.

Co-trimoxazole (trimethoprim-sulphamethoxazole combination) was effective in the control of the acute infection in 60 patients with proven enteric fever. The mean interval between initiating treatment and defervescence was similar to that observed with a comparable group of 38 patients treated with chloramphenicol. Both co-trimoxazole and chloramphenicol were well tolerated and no serious adverse reactions, attributed to either drug, were noted. Two patients treated with chloramphenicol relapsed. No relapses were noted in the co-trimoxazole treated group. Although the evidence available at present in inadequate for drawing final conclusions regarding the relative efficacy of these two therapeutic agents in enteric fever, co-trimoxazole should be considered as an alternative drug, particularly when encountering salmonella strains resistant to chloramphenicol and ampicillin.

Adolescent↗
PubMed1971

Gas gangrene.

Explore the source record for details and available documents.

Adult↗
PubMedDate not supplied

Pneumococcal cellulitis.

We are reporting a case of pneumococcal cellulitis with bacteremia in a patient with familial Mediterranean fever (FMF) and nephrotic syndrome. Four cases of pneumococcal cellulitis in adults have been reported in the literature. The potential etiologic role of Streptococcus pneumoniae in skin infections is pointed out, and possible predisposing factors and contributory conditions are described.

Adult↗
PubMedDate not supplied

Brucella-infected ovarian dermoid cyst causing initial treatment failure in a patient with acute brucellosis.

A 37-year-old woman was diagnosed with acute brucellosis. Despite appropriate antimicrobial therapy, high fever persisted. A contrast enhanced CT scan of the abdomen and pelvis revealed a left ovarian dermoid cyst. On the first postoperative day after left ovariectomy and right ovarian cystectomy were performed, the patient defervesced abruptly and continued to be completely afebrile. Cultures from bone marrow and dermoid cyst grew Brucella melitensis. The observation of a Brucella-infected ovarian dermoid cyst, which has not been previously reported, illustrates the importance of localized brucellosis as a cause of persistent infection despite appropriate antimicrobial therapy.

Adult↗
PubMedDate not supplied

Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon.

HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol, and the unclassifiable-subtype(env)/unclassifiable-subtype(pol)/Agag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development.

Adult↗