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Biomedical subjects

M Ueda

Publications and source records attributed to M Ueda.

At least 1,387 records · Page 77Linked to original sources
PubMed1982

Transplantation of the reversed dermis from skin leading to repair of the buccal mucosal epithelium.

Skin grafting or mucosal grafting has been widely applied as the established method to compensate mucosal defects. However, in the grafted skin the epidermis never transformed into the mucosal epithelium; the original nature of the transplant was maintained as skin. The available donor of mucosa is also strictly limited. Therefore, an improvement in method has been much needed in the field of oral surgery. We tried to transplant the dermis freed completely from the epidermis instead of the full-thickness skin, and succeeded in compensation of the mucosal defect. The defects of the buccal mucosa in 30 dogs were repaired, one side with reversed dermis graft (RDG) in which the dermis was turned inside out and sutured onto the bed. On the other side, the ordinary free full-thickness skin graft (FTSG) was carried out as a control. Comparative clinical and histological observations were conducted to analyze the healing processes. In RDG the graft was covered by the surrounding mucosal epithelium to form the mucosal tissue, while the implanted tissue inhibited the wound constricture. Histological examination revealed that the epithelial elements underwent degeneration, presumably through being embedded by the grafting of the dermis inside out. The epithelium covering the dermis graft seems to be nothing but normal oral mucosal epithelium.

Animals↗
PubMed1982

[Antihypertensive and related hemodynamic effects of a thiazide in desoxycorticosterone (DOC)/saline hypertensive rats].

Antihypertensive and related hemodynamic effects of trichlormethiazide (TCM), a thiazide, in DOC/saline hypertensive rats were investigated. To prepare hypertensive rats, 7-week-old male Wistar rats were subjected to nephrectomy of the left kidney, subcutaneously administered DOC (5 mg/kg X 3 times/week, or a 25-mg tablet), and given 1% saline solution as drinking water. When the systolic blood pressure of the rats reached about 200 mmHg, once-a-day oral administration of an arabic gum suspension of TCM was started. The results were: 1) Oral administration of TCM at no less than 3 mg/kg/day showed a dose-dependent, lasting antihypertensive effect throughout the experimental periods. 2) TCM administration effectively prevented the appearance of malignant hypertensive symptoms such as body weight loss, ischemia of the ocular fundus, and slight paralysis of extremities with the following pathological changes: hyalinization and fibrinoid necrosis of renal arteries and glomeruli, degeneration of renal tubules, and cardiac hypertrophy. 3) Although TCM had no effect throughout the experimental periods on the cardiac output (CO), which was determined by a modified dye-dilution method, total peripheral resistance (TPR) decreased from the first week of TCM administration. The antihypertensive effect of TCM in DOC/saline hypertensive rats is presumed to be associated with the decrease of TPR from early stages of therapy.

Animals↗
PubMed1982

[Spectral analysis of finger photoelectric plethysmogram in its relation to emotion: visual display of baseline deflection and pulse wave].

The present study applied spectral analysis of finger photoelectric plethysmogram (PTG) to describe the emotional factor involved in baseline deflection of PTG. Using 23 normal male students as subjects, PTG was measured under rest, verbal instruction, and electric shock conditions. PTG spectral analysis via fast Fourier transform was carried out on the consecutive 10 X 9 ms X 1 024 points X 4(398.64 s) samples in each condition with frequency resolution at 0.0109 Hz. In the analysis of power spectra, two distinct power peaks were observed in all conditions; below 0.3 Hz and around 1.0 Hz. It was confirmed that the former was baseline deflection and the latter was heart beat component. There were no differences in each peak frequency among conditions. Whereas peak power below 0.3 Hz tended to increase all through verbal instruction and electric shock conditions as compared to rest one. These results were discussed in relation to anxiety involved in emotion.

Adult↗
PubMed1982

[Clinical study of phase analysis by RI multigated method].

Phase analysis using RI multigated method was performed in 32 patients with various conditions including right and left bundle branch blocks (RBBB and LBBB), myocardial infarction, WPW syndrome, QT prolongation syndrome, atrioventricular (A-V) dissociation, valvular heart disease, and others. Pixel numbers were plotted into the histogram regarding the one cardiac cycle as 360 degrees. Standard deviation (S.D.) of a phase was calculated from the histogram in order to quantify asynchrony of the ventricles. Results were as follows: 1. Phase analysis was useful as a parameter of asynchrony. 2. There was a close negative correlation between left ventricular ejection fraction (LVEF) and S.D. of a phase. (r = -0.86, n = 32, p less than 0.001) 3. A marked time lag was observed in the infarcted area, and its value was mild in RBBB and LBBB. 4. A time lag between right and left ventricles was diminished or slightly reversed in the cases of RBBB with left anterior hemiblock compared to the cases of lone RBBB. 5. No significant changes were observed in other heart diseases with phase analysis.

Arrhythmias, Cardiac↗